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Cited by 52Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

The effect of iodide on serum thyroid hormone levels in normal persons, in hyperthyroid patients, and in hypothyroid patients on thyroxine replacement*

Phillppou, George, Koutras, Demetrios A., Plperlngos, Gregory, Souvatzoglou, Athanasslos, Moulopoulos, Spyrldon D.·1992·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1992.tb02267.x
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Abstract

OBJECTIVE To clarify the duration and the extent of the antithyroid effect of lodides In hyperthyroldlsm, and to Investigate whether Iodides have an additional perlpheral effect on the metabollsm of thyrold hormones, as has been reported for some organic IodIne compounds. DESIGN The effect on the perIpheral thyroId hormone levels of 150 mg of potassIum Iodide dally (equIvalent to 114 mg of IodIde) foro 3–7 weeks was compared In 21 hyperthyroId patients and 12 healthy controls. A possible effect of IodIde on the perIpheral metabollsm of thyroId hormones was Investigated by assessing the serum levels of thyroid hormone In 12 hypothyroid patients on thyroxine replacement for 2 weeks. PATIENTS There were 21 thyrotoxic patients, 12 healthy hospital controls, and 12 patients with complete or near‐complete hypothyroldlsm, on thyroxine replacement. MEASUREMENTS The following were measured before and at weekly intervals after Iodide administration: (1) pulse rate, (2) serum T4, (3) serum T3, (4) serum TSH, (5) serum thyroxlne‐binding capacity (TBC), (6) serum rT3, (7) serum thyroxine‐binding globulln (TBG), (8) the free‐T4 Index, calculated as T4/TBC. RESULTS In the hyperthyroid patients serum T4, T3 and rT3 decreased, whereas serum thyroxlne‐binding globulin and thyroxine binding capacity Increased. Serum T3, however, did not become completely normal In all cases. After 21 days, serum T4 and T3 started Increasing again in some cases, but other patients remained outhyrold even after 6 weeks. In the normal controls there was a small but significant and consistent decrease In serum T4, T3 and rT3 and an Increase In serum TSH. Finally, In the T4‐treated hypothyroid patients there was no consistent change, except for an Increase of serum T4 at 1 and 14 days and a decrease of serum TSH the first day. CONCLUSION Iodides in hyperthyroldlsm have a variable and unpredictable Intensity and duration of antlthyrold effect. Their antithyroid effect Is smaller In normal controls. They have no Important effect on the peripheral metabolism of thyroid hormones.

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Authors
Phillppou, G., Koutras, D. A., Plperlngos, G., Souvatzoglou, A., & Moulopoulos, S. D.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Koutras, Demetrios A.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1992-06
Volume
36
Issue
6
Pages
573-578
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1992.tb02267.x
OpenAlex
W1999844440
Cited by
52
References
24
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5768 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
iodide, potassium iodide, hyperthyroidism, hypothyroidism, thyroxine replacement, serum thyroid hormones, thyroid-stimulating hormone, thyroxine-binding globulin, thyroxine-binding capacity, reverse T3, antithyroid effect
MeSH terms
Adult, Aged, Female, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Potassium Iodide, Thyroid Gland, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse

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