Serum Thyroxine and Triiodothyronine Concentrations During Iodide Treatment of Hyperthyroidism
Abstract
Serum thyroxine (T4) and triiodothyronine (T3) concentrations were measured at frequent intervals in 9 hyperthyroid patients treated with iodide alone. Serum T4 and T3 levels fell initially in all patients. In 6 patients, after a mean fall in serum T4 of 46% and in serum T3 of 47% after 4 to 11 days of therapy, thyroid hormone levels began to rise. In the 3 remaining patients a rise in thyroid hormone levels was not seen following the initial fall. However, in one of this group T4 and T3 levels did not reach the normal range despite 60 days of therapy. These data support the concept that iodide alone is not an ideal agent for the treatment of hyperthyroidism.
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Iodine acutely lowers thyroid hormone concentrations by reducing hormone secretion and inhibits its own organification (the Wolff-Chaikoff effect).
“Iodine acutely lowers thyroid hormone concentrations by reducing hormone secretion (238,239), and inhibits its own organification (the Wolff-Chaikoff effect) (240).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [238]
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“Iodine acutely lowers thyroid hormone concentrations by reducing hormone secretion (238,239), and inhibits its own organification (the Wolff–Chaikoff effect) (240).”
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Self-citation
- Authors
- EMERSON, C. H., ANDERSON, A. J., HOWARD, W. J., & UTIGER, R. D.
- Affiliations
- University of Pennsylvania (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1975-01
- Volume
- 40
- Issue
- 1
- Pages
- 33-36
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2069010991
- Cited by
- 92
- References
- 0
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 7 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- hyperthyroidism, iodide therapy, serum thyroxine, serum triiodothyronine, thyroid hormone levels, antithyroid drug therapy
- MeSH terms
- Adult, Female, Humans, Hyperthyroidism, Iodine, Male, Radioimmunoassay, Thyroxine, Time Factors, Triiodothyronine
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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