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Cited by 25Growth Hormone and Insulin-like Growth FactorsBone health and osteoporosis researchGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

The effect of growth hormone treatment on bone mineral density in prepubertal girls with Turner syndrome: a multicentre prospective clinical trial

Aycan, Zehra, Cetinkaya, Ergun, Darendeliler, Feyza, Vidinlisan, Sadi, Bas, Firdevs, Bideci, Aysun, Demirel, Fatma, Darcan, Sukran +4 more·2008·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2007.03107.x
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Abstract

BACKGROUND: Patients with Turner syndrome (TS) are treated with GH to increase adult height. Although it is well established that GH promotes longitudinal bone growth, the effects of GH treatment on bone density are less clear. OBJECTIVE: To determine how GH treatment affects trabecular bone mineral density (BMD) in girls with TS at prepubertal ages in a prospective multicentre study. PATIENTS AND METHOD: Twenty-two patients with TS in the prepubertal period with a mean age of 9.8 +/- 2.5 (range 3.6-12.8) years were included in the study. All girls with TS underwent measurement of areal BMD using dual-energy X-ray absorptiometry (DXA) to obtain pretreatment anteroposterior (AP) lumbar spine values at L1-L4. Patients received GH (Genotropin) subcutaneously for 1 year at a dose of 0.05 mg/kg/day. Height and weight were measured at 3-monthly intervals. The AP lumbar spine areal BMD was remeasured using the same technique after 1 year of treatment. Lumbar spine BMD Z-scores and volumetric BMD (vBMD) Z-scores were calculated using national standards. RESULTS: The height SDS of our cases showed a significant increase with GH therapy. The pretreatment lumbar spine (L1-L4) BMD Z-score was -1.2 +/- 1.2 SD and the vBMD Z-score was -0.8 +/- 1.6 SD. There were no significant changes in these values after 1 year of GH treatment. Prepubertal TS girls more than 11 years of age had lower vBMD Z-scores (-1.7 +/- 1.7 SD) than the girls aged less than 11 (-0.1 +/- 1.0 SD) (P < 0.05) at the onset of therapy. No significant changes were observed in these values after 1 year of GH therapy. CONCLUSIONS: Osteopaenia becomes apparent in prepubertal TS patients as they reach pubertal age. BMD evaluation may be necessary in these prepubertal TS girls at diagnosis. Short-term GH therapy in these TS patients does not have a significant effect on bone density when measured at a site with a predominance of trabecular bone.

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Authors
Aycan, Z., Cetinkaya, E., Darendeliler, F., Vidinlisan, S., Bas, F., Bideci, A., Demirel, F., Darcan, S., Buyukgebiz, A., Yildiz, M., Berberoglu, M., & Bundak, R.
Affiliations
Zonguldak Bülent Ecevit University (TR)
Corresponding author
Aycan, Zehra
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2007-11-02
Volume
68
Issue
5
Pages
769-772
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2007.03107.x
OpenAlex
W2124782887
Cited by
25
References
25
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2019: 2 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Zonguldak Bülent Ecevit University Institutional Repository (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords
Turner syndrome, growth hormone therapy, bone mineral density, prepubertal girls, lumbar spine, trabecular bone, osteopenia, height gain, puberty onset
MeSH terms
Bone Diseases, Metabolic, Child, Child, Preschool, Female, Humans, Puberty, Turner Syndrome, Absorptiometry, Photon, Bone Density, Treatment Outcome, Human Growth Hormone

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