Increases in muscle blood flow after a mixed meal are impaired at all stages of type 2 diabetes
Abstract
OBJECTIVE: In type 2 diabetes, although the impairment of postprandial muscle blood flow response is well established, information on the effect of this impairment on glucose uptake and lipid metabolism is controversial. DESIGN: Postprandial forearm blood flow responses and metabolic parameters were assessed in a cross-sectional study of subjects at various stages of insulin resistance. PATIENTS: Eleven healthy subjects (CONTROLS), 11 first-degree relatives of type-2 diabetics (RELATIVES), 10 patients with impaired glucose tolerance (IGT), 10 diabetic patients with postprandial hyperglycaemia (DMA), and 13 diabetic patients with both fasting and postprandial hyperglycaemia (DMB). MEASUREMENTS: All subjects received a meal. Blood was drawn from a forearm deep vein and the radial artery at specific time-points during a period of 360 min for measurements of glucose, insulin, triglycerides and nonesterified-fatty acids. Forearm muscle blood flow was measured with strain-gauge plethysmography. Glucose uptake and ISI Index were calculated. RESULTS: Peak-baseline muscle blood flow was higher in CONTROLS (3.32 ± 0.4) than in RELATIVES (0.53 ± 0.29), IGT (0.82 ± 0.2), DMA (1.44 ± 0.34), DMB (1.23 ± 0.35 ml/min/100 ml tissue), P < 0.001. Glucose uptake (AUC(0-360,) μmol/100 ml tissue) was higher in CONTROLS (1023 ± 132) than in RELATIVES (488 ± 42), IGT (458 ± 43), DMA (347 ± 63), DMB (543 ± 53), P < 0.001. ISI index, postprandial triglycerides and nonesterified-fatty acids behaved in a similar way. Peak-baseline muscle blood flow correlated positively with glucose uptake (r = 0.440, P = 0.001) and ISI index (r = 0.397, P = 0.003), and negatively with postprandial triglycerides (r = -0.434, P = 0.001) and nonesterified-fatty acids (r = -0.370, P = 0.005). CONCLUSIONS: These results suggest that increase in muscle blood flow after a meal is impaired at all stages of type-2 diabetes. This defect influences glucose uptake and is associated with impaired lipid metabolism in the postprandial state.
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In conditions such as IGT, T2DM or obesity, insulin-stimulated rates of blood flow in adipose tissue and muscle are severely impaired.
“In conditions such as IGT, T2DM or obesity, insulin-stimulated rates of blood flow in adipose tissue and muscle are severely impaired [54,55,56].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [54]
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- Authors
- Lambadiari, V., Mitrou, P., Maratou, E., Raptis, A., Raptis, S. A., & Dimitriadis, G.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Dimitriadis, George
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2012-04-23
- Volume
- 76
- Issue
- 6
- Pages
- 825-830
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W1556821477
- Cited by
- 16
- References
- 39
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 1 · 2015: 3 · 2014: 1 · 2012: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- type 2 diabetes, muscle blood flow, postprandial hyperglycemia, insulin resistance, impaired glucose tolerance, glucose uptake, insulin sensitivity index, postprandial triglycerides, free fatty acids, mixed meal, first-degree relatives of diabetics, lipid metabolism, insulin secretion, first-phase insulin response, second-phase insulin response, postprandial lipemia, postprandial hyperinsulinemia
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Humans, Insulin, Male, Middle Aged, Triglycerides, Muscle, Skeletal, Postprandial Period
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