Impaired postprandial blood flow in adipose tissue may be an early marker of insulin resistance in type 2 diabetes
Abstract
OBJECTIVE: We investigated the changes in subcutaneous adipose tissue blood flow (ATBF) after a meal in the various stages of type 2 diabetes. RESEARCH DESIGN AND METHODS: Five groups were examined: healthy control subjects, first-degree relatives of subjects with type 2 diabetes, subjects with impaired glucose tolerance (IGT), subjects with type 2 diabetes and postprandial hyperglycemia but normal fasting plasma glucose levels (diabetes group A [DMA]), and subjects with type 2 diabetes with both postprandial and fasting hyperglycemia (diabetes group B [DMB]). ATBF was measured with (133)Xe. RESULTS: ATBF was higher in control subjects (1,507 +/- 103 ml/100 cm(3) tissue x min) versus relatives and IGT, DMA, and DMB subjects (845 +/- 123, 679 +/- 69, 765 +/- 60, and 757 +/- 69 ml/100 cm(3) tissue x min, respectively; P < 0.001). Insulin sensitivity index (ISI) in control subjects (82 +/- 3 mg x l(2)/mmol x mU x min) was higher versus that for relatives and IGT, DMA, and DMB subjects (60 +/- 3, 45 +/- 1, 40 +/- 6, and 29 +/- 4 mg x l(2)/mmol x mU x min, respectively; P < 0.0001). ISI was positively associated with peak-baseline ATBF (beta coefficient 0.029 +/- 0.013, P = 0.03). CONCLUSIONS: After meal ingestion, insulin-stimulated ATBF was decreased in relatives and and IGT, DMA, and DMB subjects. This defect could be an early marker of insulin resistance that precedes the development of type 2 diabetes.
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In conditions such as IGT, T2DM or obesity, insulin-stimulated rates of blood flow in adipose tissue and muscle are severely impaired.
“In conditions such as IGT, T2DM or obesity, insulin-stimulated rates of blood flow in adipose tissue and muscle are severely impaired [54,55,56].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [55]
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- Authors
- Dimitriadis, G., Lambadiari, V., Mitrou, P., Maratou, E., Boutati, E., Panagiotakos, D. B., Economopoulos, T., & Raptis, S. A.
- Affiliations
- University General Hospital Attikon (GR)
- 2nd Department of Internal Medicine—Propaedeutic and Research Institute, Athens University Medical School, “Attikon” University Hospital Athens, Greece
- Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), Athens, Greece
- Harokopio University of Athens (GR)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2007-12-01
- Volume
- 30
- Issue
- 12
- Pages
- 3128-3130
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2127727717
- Cited by
- 52
- References
- 15
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- insulin resistance, type 2 diabetes, impaired glucose tolerance, postprandial hyperglycemia, insulin sensitivity index, first-degree relatives
- MeSH terms
- Adipose Tissue, Adult, Blood Flow Velocity, Diabetes Mellitus, Type 2, Eating, Family, Fatty Acids, Nonesterified, Humans, Insulin Resistance, Reference Values, Skin, Biomarkers, Body Mass Index, Postprandial Period
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