Cited by 209Hormonal and reproductive studiesSperm and Testicular FunctionAdrenal Hormones and Disorders

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Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study

Sartorius, Gideon, Spasevska, Sasa, Idan, Amanda, Turner, Leo, Forbes, Elise, Zamojska, Anna, Allan, Carolyn A., Ly, Lam P., Conway, Ann J., McLachlan, Robert I., Handelsman, David J.·2012·Clinical Endocrinology

DOI 10.1111/j.1365-2265.2012.04432.x

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Abstract

Summary: Objective: To determine serum concentrations, intra‐individual variability and impact of age‐related co‐morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E 2) and estrone (E 1) in older men. Design: Observational, repeated measures study. Participants: Men (n = 325) with 40 years and older self‐reporting very good or excellent health. Measurements: Standardized history, physical examination and collection of nine blood samples at fixed time intervals were measured over 3 months (three at 20 min intervals on days 1 (fasting) and 2 (non‐fasting), one at days 7, 30 and 90). Serum T, DHT, E 2 and E 1 (n = 2900, > 99% of scheduled samples) measured by liquid chromatography‐tandem mass spectrometry (LC‐MS) were analysed by linear mixed model analysis with fasting, age and obesity as covariables. Results: Mean serum T did not vary with age (P = 0·76) but obesity (−0·35 n m per body mass index (BMI) unit, P < 0·0001) and ex‐smoker status (−1·6 n m, P < 0·001) had significant effects. Serum DHT was increased with age (+0·011 n m per year, P = 0·001) but decreased with obesity (−0·05 n m per BMI unit, P < 0·0001). Serum E 2 did not vary with age (P = 0·31) or obesity (P = 0·12). Overnight fasting increased (by 9–16%, all P < 0·001) and reduced variability in morning serum T, DHT, E 2 and E 1. Non‐fasting serum T and DHT were stable over time (day, week, month or 3 months; P > 0·28). Conclusions: Serum T, DHT and E 2 displayed no decrease associated with age among men over 40 years of age who self‐report very good or excellent health although obesity and ex‐smoking status were associated with decreased serum androgens (T and DHT) but not E 2. These findings support the interpretation that the age‐related decline in blood T accompanying non‐specific symptoms in older men may be due to accumulating age‐related co‐morbidities rather than a symptomatic androgen deficiency state.

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Authors: Sartorius, G., Spasevska, S., Idan, A., Turner, L., Forbes, E., Zamojska, A., Allan, C. A., Ly, L. P., Conway, A. J., McLachlan, R. I., & Handelsman, D. J.
Affiliations: The University of Sydney (AU)
Concord Hospital (US)
Prince Henrys Institute Clayton
Corresponding author: Handelsman, David J.
ORCID: Sartorius, Gideon
Turner, Leo
Allan, Carolyn A.
Conway, Ann J.
McLachlan, Robert I.
Handelsman, David J.
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 2012-10-05
Volume: 77
Issue: 5
Pages: 755-763
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1111/j.1365-2265.2012.04432.x
OpenAlex: W1984060669
Cited by: 209
References: 41
Citations by year: 2026: 6 · 2025: 4 · 2024: 5 · 2023: 24 · 2022: 9 · 2021: 10 · 2020: 14 · 2019: 14 · 2018: 12 · 2017: 16 · 2016: 26 · 2015: 23 · 2014: 23 · 2013: 18 · 2012: 4
FWCI: 17.45
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Bupa Foundation
Bupa Health Foundation
Centers for Disease Control and Prevention
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: serum testosterone, dihydrotestosterone, estradiol, estrone, older men, aging, obesity, smoking, fasting effects, diurnal variation, androgen levels, healthy aging
MeSH terms: Aged, Estradiol, Humans, Male, Middle Aged, Dihydrotestosterone, Testosterone

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Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study

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