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Cited by 43Cardiovascular Function and Risk FactorsHeart Failure Treatment and ManagementBlood Pressure and Hypertension Studies

Natriuretic peptides as markers of preclinical cardiac disease in obesity

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Grandi, A. M., Laurita, E., Selva, E., Piantanida, E., Imperiale, D., Giovanella, L., Guasti, L., Venco, A.·2004·European Journal of Clinical Investigation
DOI 10.1111/j.1365-2362.2004.01348.x
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Abstract

Background Aim of the study was to evaluate the role of atrial (ANP) and brain natriuretic peptides (BNP) as markers of preclinical cardiac disease in obesity. Methods We selected 26 obese (BMI > 29 kg m−2) never‐treated hypertensives (24‐h BP > 140 and/or 90 mmHg), 26 obese normotensives (24‐h BP < 130/80 mmHg) and 25 lean (BMI 25 kg m−2) never‐treated hypertensives. Each subject underwent measurements of ANP and BNP plasma levels, 24‐h ambulatory blood pressure (BP) monitoring, digitized M‐mode and Doppler echocardiography. Results Mean values of ANP and BNP were similar among the three groups. All the subjects had normal left ventricular (LV) systolic function. Within each group ANP levels were higher in patients with LV diastolic dysfunction than in patients with normal diastolic function, and BNP levels were higher in patients with LV hypertrophy and in patients with LV diastolic dysfunction. Within each group, ANP levels were inversely correlated with LV diastolic indices, whereas BNP levels were directly correlated with LV mass index and inversely correlated with LV diastolic indices. ANP and BNP levels were not correlated with other echocardiographic parameters, age, BMI or 24‐h BP values. Conclusion In normotensive and hypertensive obese subjects the relationships of ANP and BNP levels with LV morpho‐functional characteristics follow the same trend as in lean hypertensives, with ANP mainly influenced by diastolic dysfunction and BNP influenced by both LV hypertrophy and LV diastolic dysfunction. Therefore ANP and BNP can be considered useful markers of preclinical cardiac disease in obesity.

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  • Other studies found no correlation or even a positive correlation between BMI and plasma natriuretic peptide concentrations.

    “Other studies, however, found no correlation or even a positive correlation between BMI and plasma NP concentrations94,95.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [94]

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Authors
Grandi, A. M., Laurita, E., Selva, E., Piantanida, E., Imperiale, D., Giovanella, L., Guasti, L., & Venco, A.
Affiliations
University of Insubria (IT)
Corresponding author
Grandi, A. M.
ORCID
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
2004-05
Volume
34
Issue
5
Pages
342-348
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1111/j.1365-2362.2004.01348.x
OpenAlex
W2151036355
Cited by
43
References
33
Citations by year
2022: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
3.27
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 16 d)
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
natriuretic peptides, atrial natriuretic peptide, brain natriuretic peptide, obesity, left ventricular diastolic dysfunction, left ventricular hypertrophy, left ventricular mass, hypertension, biomarkers, ambulatory blood pressure
MeSH terms
Adult, Female, Heart Diseases, Heart Ventricles, Humans, Hypertension, Male, Middle Aged, Atrial Natriuretic Factor, Obesity, Biomarkers, Ventricular Function, Left, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain, Natriuretic Peptides

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