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Cited by 39Cardiovascular Function and Risk FactorsBlood Pressure and Hypertension StudiesCardiovascular Disease and Adiposity

Obesity and left ventricular diastolic function: noninvasive study in normotensives and newly diagnosed never-treated hypertensives

Grandi, AM, Zanzi, P, Piantanida, E, Gaudio, G, Bertolini, A, Guasti, L, Venco, A·2000·International Journal of Obesity
DOI 10.1038/sj.ijo.0801261
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Abstract

Objective To evaluate the influence of obesity, per se or associated with hypertension, on left ventricular (LV) diastolic function.Patients Thirty-two obese newly-diagnosed never-treated hypertensives; 32 obese normotensives matched for age, sex and BMI with hypertensives; 32 lean newly diagnosed never-treated hypertensives and 32 lean normotensives, matched for age, sex and 24 h blood pressure (BP) with the obese subjects.Methods Twenty-four-hour ambulatory blood pressure monitoring and digitized M-mode LV echocardiograms. PARAMETERS EVALUATED: Twenty-four-hour, day-time and night-time BP and heart rate, percentage nocturnal BP fall; LV end-diastolic diameter index, septal and posterior wall thickness, LV mass index, peak shortening and lengthening rate of LV diameter, peak thinning rate of LV posterior wall.Results A main effect was found for obesity on LV diameter and LV mass and for hypertension on LV mass; LV systolic function was normal in all the subjects and similar among the four groups; LV diastolic function was significantly reduced in both obese groups with respect to lean ones. This difference persisted after correction of diastolic parameters for 24 h BP and heart rate, LV diameter and LV mass index and disappeared only after correction for body mass index. This latter was inversely related with diastolic parameters only in the obese groups.Conclusions Obesity is associated with a preclinical impairment of LV diastolic function in both normotensives and hypertensives; the diastolic impairment is independent of haemodynamic factors, such as 24 h BP and heart rate, and bears no relation to LV geometry in normotensives and only little relation in hypertensives, having therefore to be ascribed to obesity itself.

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Crossref · 10.1038/sj.ijo.0801261

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  • Many published studies have concluded that obesity is independently associated with LV hypertrophy.

    “Many published studies have concluded that obesity is independently associated with LV hypertrophy (22, 28, 63, 72, 116, 235, 242, 266, 279, 284, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [116]

  • Findings on LV ejection fraction in obese subjects are variable, with studies reporting depressed, normal, or supernormal EF.

    “Various authors have reported depressed LV ejection fraction (EF) (15, 68, 100), normal EF (22, 111, 116, 191, 242, 266, 279, 377), and supernormal EF (28, 155, 274, 375) in obese subjects.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [116]

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Authors
Grandi, A., Zanzi, P., Piantanida, E., Gaudio, G., Bertolini, A., Guasti, L., & Venco, A.
Affiliations
University of Insubria (IT)
Corresponding author
Grandi, AM
ORCID
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2000-08
Volume
24
Issue
8
Pages
954-958
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/sj.ijo.0801261
OpenAlex
W2081492311
Cited by
39
References
34
Citations by year
2021: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
obesity, left ventricular diastolic function, hypertension, newly diagnosed hypertension, normotension, body mass index, left ventricular mass, left ventricular geometry, ambulatory blood pressure, heart rate, diastolic dysfunction
MeSH terms
Adult, Analysis of Variance, Blood Pressure, Diastole, Echocardiography, Female, Humans, Hypertension, Male, Obesity, Case-Control Studies, Ventricular Dysfunction, Left, Blood Pressure Monitoring, Ambulatory

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