The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulation of adipokine production in human adipose tissue by propionic acid
Abstract
Eur J Clin Invest 2010; 40 (5): 401–407 Background Dietary fibre (DF) has been shown to be protective for the development of obesity, insulin resistance and type 2 diabetes. Short‐chain fatty acids, produced by colonic fermentation of DF might mediate this beneficial effect. Adipose tissue plays a key role in the regulation of energy homeostasis, therefore, we investigated the influence of the short‐chain fatty acid propionic acid (PA) on leptin, adiponectin and resistin production by human omental (OAT) and subcutaneous adipose tissue (SAT). As PA has been shown to be a ligand for G‐protein coupled receptor (GPCR) 41 and 43, we investigated the role of GPCR’s in PA signalling. Materials and methods Human OAT and SAT explants were obtained from gynaecological patients who underwent surgery. Explants were incubated for 24 h with PA. Adipokine secretion and mRNA expression were determined using ELISA and RT‐PCR respectively. Results We found that PA significantly stimulated leptin mRNA expression and secretion by OAT and SAT, whereas it had no effect on adiponectin. Furthermore, PA reduced resistin mRNA expression. Leptin induction, but not resistin reduction, was abolished by inhibition of Gi/o‐coupled GPCR signalling. Moreover, GPCR41 and GPCR43 mRNA levels were considerably higher in SAT than in OAT. Conclusions We demonstrate that PA stimulates expression of the anorexigenic hormone leptin and reduces the pro‐inflammatory factor resistin in human adipose tissue depots. This suggests that PA is involved in regulation of human energy metabolism and inflammation and in this way may influence the development of obesity and type 2 diabetes.
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“increasing among others fat oxidation and energy expenditure [16].”
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Associations of Adiponectin, Resistin, and Tumor Necrosis Factor-α with Insulin Resistance
Hivert, M.-F., Sullivan, L. M., Fox, C. S., Nathan, D. M., D’Agostino, R. B., Wilson, P. W. F., & Meigs, J. B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0425 · Cited by 262
Cited by
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298
Gut microbial metabolites in obesity, NAFLD and T2DM
Canfora, E. E., Meex, R. C. R., Venema, K., & Blaak, E. E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0156-z · Cited by 1,493
Self-citationKimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106
Short chain fatty acids in human gut and metabolic health
Blaak, E. E., Canfora, E. E., Theis, S., Frost, G., Groen, A. K., Mithieux, G., Nauta, A., Scott, K., Stahl, B., van Harsselaar, J., et al. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0057 · Cited by 1,103
Metadata
- Authors
- Al‐Lahham, S. H., Roelofsen, H., Priebe, M., Weening, D., Dijkstra, M., Hoek, A., Rezaee, F., Venema, K., & Vonk, R. J.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2010-04-20
- Volume
- 40
- Issue
- 5
- Pages
- 401-407
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2121430417
- Cited by
- 222
- References
- 6
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Al‐Lahham, S. H., Roelofsen, H., Priebe, M., Weening, D., Dijkstra, M., Hoek, A., Rezaee, F., Venema, K., & Vonk, R. J. (2010). Regulation of adipokine production in human adipose tissue by propionic acid. European Journal of Clinical Investigation. https://doi.org/10.1111/j.1365-2362.2010.02278.x
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