Cited by 262Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Associations of Adiponectin, Resistin, and Tumor Necrosis Factor-α with Insulin Resistance

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Hivert, Marie-France, Sullivan, Lisa M., Fox, Caroline S., Nathan, David M., D’Agostino, Ralph B., Wilson, Peter W. F., Meigs, James B.·2008·The Journal of Clinical Endocrinology & Metabolism

Abstract

CONTEXT: Adipose tissue-derived adipokines may contribute to insulin resistance. OBJECTIVE: We tested the hypothesis that adipokines are associated with insulin resistance in a community-based cohort and that associations are maintained in people with and without the metabolic syndrome (high vs. low risk of diabetes). DESIGN, SETTING, AND PARTICIPANTS: We studied a cross-sectional sample of 2356 individuals attending the seventh examination (1998-2001) of the Framingham Offspring Study. We measured levels of glucose, insulin, adiponectin, resistin, and TNFalpha in fasting blood samples and defined metabolic syndrome by updated National Cholesterol Education Program criteria. We used ANOVA to test associations of adipokines with insulin resistance and multivariable logistic regression models to assess joint associations of adipokines and metabolic syndrome with insulin resistance. MAIN OUTCOME MEASURE: Homeostasis model (HOMA-IR), with insulin resistance defined by HOMA-IR greater than the 75th percentile, was measured. RESULTS: Age- and sex-adjusted HOMA-IR levels were inversely related to adiponectin (r = -0.40, P < 0.0001) and positively related to resistin (r = 0.13, P < 0.0001) and TNFalpha (r = 0.12, P < 0.0001). The prevalence of insulin resistance increased with decreasing tertiles of adiponectin (from 10.9% in the third to 42.5% in the first tertile; P < 0.0001) and increasing tertiles of resistin (from 19.3 to 30.9%; P < 0.0001) and TNFalpha (from 18.8 to 32.0%; P < 0.0001). Results were similar after adjustment for body mass index. These associations were present in individuals with or without the metabolic syndrome. In multivariable regression models, metabolic syndrome and adipokines individually and jointly were significantly associated with insulin resistance. CONCLUSION: Adverse levels of adipokines are associated with insulin resistance in individuals at low or high diabetes risk.

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  • In humans, plasma adiponectin levels correlated negatively with insulin resistance, and higher levels correlated with future weight gain in 1,063 women.

    “In humans, plasma adiponectin levels correlated negatively with insulin resistance, and higher levels correlated with future weight gain in 1,063 women.63,64”

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Authors
Hivert, M.-F., Sullivan, L. M., Fox, C. S., Nathan, D. M., D’Agostino, R. B., Wilson, P. W. F., & Meigs, J. B.
Affiliations
  • Massachusetts General Hospital (US)
  • Boston University (US)
  • Harvard University (US)
  • Emory University (US)
Corresponding author
Meigs, James B.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2008-08-01
Volume
93
Issue
8
Pages
3165-3172
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2035812981
Cited by
262
References
45
Citations by year
2026: 1 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 14 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 25 · 2014: 20 · 2013: 24 · 2012: 24
FWCI
18.31
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc25195-41-0-1)
  • U.S. Public Health Service (K24 DZK080140)
  • National Heart, Lung, and Blood Institute (N01‐HC25195, N01-HC-025195)
  • National Institute of Diabetes and Digestive and Kidney Diseases (K24DK080140)
  • National Center for Research Resources (M01RR001066, M01-RR01066)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
insulin resistance, adiponectin, resistin, TNF-α, adipokines, metabolic syndrome, type 2 diabetes risk, HOMA-IR, adipose tissue, Framingham Offspring Study
MeSH terms
Aged, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Male, Middle Aged, Tumor Necrosis Factor-alpha, Body Mass Index, Logistic Models, Adiponectin, Resistin

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