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Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP‐A chromatin of human cells
Abstract
The centromere is a chromatin structure essential for correct segregation of sister chromatids, and defects in this region often lead to aneuploidy and cancer. We have previously reported purification of the interphase centromere complex (ICEN) from HeLa cells, and have demonstrated the presence of 40 proteins (ICEN1–40), along with CENP‐A, ‐B, ‐C, ‐H and hMis6, by proteomic analysis. Here we report analysis of seven ICEN components with unknown function. Centromere localization of EGFP‐tagged ICEN22, 24, 32, 33, 36, 37 and 39 was observed in transformant cells. Depletion of each of these proteins by short RNA interference produced abnormal metaphase cells carrying misaligned chromosomes and also produced cells containing aneuploid chromosomes, implying that these ICEN proteins take part in kinetochore functions. Interestingly, in the ICEN22, 32, 33, 37 or 39 siRNA‐transfected cells, CENP‐H and hMis6 signals disappeared from all the centromeres in abnormal mitotic cells containing misaligned chromosomes. These results suggest that the seven components of the ICEN complex are predominantly localized at the centromeres and are required for kinetochore function perhaps through or not through loading of CENP‐H and hMis6 onto the centromere.
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Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota, T., Suzuki, Y., Nishikawa, T., Otsuki, T., Sugiyama, T., Irie, R., Wakamatsu, A., Hayashi, K., Sato, H., Nagai, K., et al. (2004) · Nature Genetics · doi:10.1038/ng1285 · Cited by 925
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Cited by
Molecular architecture of the kinetochore–microtubule interface
Cheeseman, I. M., & Desai, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2310 · Cited by 915
The molecular basis for centromere identity and function
McKinley, K. L., & Cheeseman, I. M. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.5 · Cited by 668
A Molecular View of Kinetochore Assembly and Function
Musacchio, A., & Desai, A. (2017) · Biology · doi:10.3390/biology6010005 · Cited by 544
Priming of Centromere for CENP-A Recruitment by Human hMis18α, hMis18β, and M18BP1
Fujita, Y., Hayashi, T., Kiyomitsu, T., Toyoda, Y., Kokubu, A., Obuse, C., & Yanagida, M. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.11.002 · Cited by 398
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Metadata
- Authors
- Izuta, H., Ikeno, M., Suzuki, N., Tomonaga, T., Nozaki, N., Obuse, C., Kisu, Y., Goshima, N., Nomura, F., Nomura, N., & Yoda, K.
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2006-05-09
- Volume
- 11
- Issue
- 6
- Pages
- 673-684
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W2021790954
- Cited by
- 216
- References
- 2
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Izuta, H., Ikeno, M., Suzuki, N., Tomonaga, T., Nozaki, N., Obuse, C., Kisu, Y., Goshima, N., Nomura, F., Nomura, N., & Yoda, K. (2006). Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP‐A chromatin of human cells. Genes to Cells. https://doi.org/10.1111/j.1365-2443.2006.00969.x
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