The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells
Open accessAbstract
The Nanog and Oct‐4 genes are essential for maintaining pluripotency of embryonic stem (ES) cells and early embryos. We previously reported that DNA methylation and chromatin remodeling underlie the cell type‐specific mechanism of Oct‐4 gene expression. In the present study, we found that there is a tissue‐dependent and differentially methylated region (T‐DMR) in the Nanog up‐stream region. The T‐DMR is hypomethylated in ES cells, but is heavily methylated in trophoblast stem (TS) cells and NIH/3T3 cells, in which the Nanog gene is repressed. Furthermore, in vitro methylation of T‐DMR suppressed Nanog promoter activity in reporter assay. Chromatin immunoprecipitation assay revealed that histone H3 and H4 are highly acetylated, and H3 lysine (K) 4 is hypermethylated at the Nanog locus in ES cells. Conversely, histone deacetylation and H3‐K4 demethylation occurred in TS cells. Importantly, in TS cells, hypermethylation of H3‐K9 and ‐K27 is found only at the Nanog locus, not the Oct‐4 locus, indicating that the combination of histone modifications associated with the Nanog gene is distinct from that of the Oct‐4 gene. In conclusion, the Nanog gene is regulated by epigenetic mechanisms involving DNA methylation and histone modifications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Detection and interpretation of altered methylation patterns in cancer cells
Ushijima, T. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1571 · Cited by 483 · cited 4×
“Furthermore, epigenetic abnormality is one of the major causes of tumorigenesis (Robertson 2005; Ushijima 2005), and especially interesting is that cancer stem cells have been characterized by the expressions of Oct-4 and Nanog (Monk & Holding 2001; Ezeh et al.”
BackgroundInfluentialA histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Hayashi, K., Yoshida, K., & Matsui, Y. (2005) · Nature · doi:10.1038/nature04112 · Cited by 472
Strain difference in establishment of mouse embryonic stem (ES) cell lines
Kawase, E., Suemori, H., Takahashi, N., Okazaki, K., Hashimoto, K., & Nakatsuji, N. (1994) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7981049 · Cited by 203
Cited by
Ito, S., D’Alessio, A. C., Taranova, O. V., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,373
DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time
Nishino, K., Toyoda, M., Yamazaki-Inoue, M., Fukawatase, Y., Chikazawa, E., Sakaguchi, H., Akutsu, H., & Umezawa, A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002085 · Cited by 314
Self-citation
Metadata
- Authors
- Hattori, N., Imao, Y., Nishino, K., Hattori, N., Ohgane, J., Yagi, S., Tanaka, S., & Shiota, K.
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2007-03
- Volume
- 12
- Issue
- 3
- Pages
- 387-396
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W2063395944
- Cited by
- 170
- References
- 3
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. https://app.cochat.ai/papers/10.1111/j.1365-2443.2007.01058.x
- The paper
- Hattori, N., Imao, Y., Nishino, K., Hattori, N., Ohgane, J., Yagi, S., Tanaka, S., & Shiota, K. (2007). Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes to Cells. https://doi.org/10.1111/j.1365-2443.2007.01058.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
