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Cited by 561

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading

BRUN, A., ENGLUND, ELISABET·1981·Histopathology
DOI 10.1111/j.1365-2559.1981.tb01818.x
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Abstract

The various structural components of the cortical degeneration of Alzheimer's disease were defined and graded. The severity of the degenerative process was thus mapped in different cortical areas where neuronal numbers and cortical width were also measured and compared with controls. Contrary to the general opinion that the degenerative process is rather uniformly diffuse, though accentuated in the medial temporal and frontal cortex, we found a consistent and more elaborate pattern with clearcut regional differences. Thus the degeneration involved, besides basal medial temporal limbic areas, the posterior cingulate gyrus and superior parietal lobule particularly, with somewhat less marked changes in the inferior parietal lobule and inferior temporal gyri. The sensorimotor, calcarine and anterior cingulate areas of the cortex were notably spared until very late stages. This regionally variable severity of the degeneration was also parallelled by a regionally varying reduction in neuronal numbers and cortical width, and agrees with our previously published results of a regional pattern which closely correlates with clinical parameters, including symptom pattern and regional cerebral blood flow alterations.

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Metadata

Authors
BRUN, A., & ENGLUND, E.
Venue
Histopathology
Publisher
Wiley
Published
1981-09
Volume
5
Issue
5
Pages
549-564
ISSN
  • 0309-0167 (ISSN-L)
  • 1365-2559
DOI
10.1111/j.1365-2559.1981.tb01818.x
OpenAlex
W2053794612
Cited by
561
References
24
FWCI
3.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading. https://app.cochat.ai/papers/10.1111/j.1365-2559.1981.tb01818.x
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BRUN, A., & ENGLUND, E. (1981). Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading. Histopathology. https://doi.org/10.1111/j.1365-2559.1981.tb01818.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.