Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia: A quantitative study
Abstract
The number of pyramidal neurones in the hippocampal cortex was determined in serially sectioned mesial temporal lobe from brains of 18 mentally normal people, as well as those of 8 demented patients with pathologically confirmed Alzheimer's disease. Normal ageing was accompanied by a gradual loss of neurones, whereas dements' brains showed a much more severe decrease, exceeding that of controls at any age. A high degree of negative exponential correlation was found between the density of neurones/mm3 of cortex and both the number of neurones with neurofibrillary degeneration and the number with granulovacular degeneration. The functional significance of the latter changes is thus probably greater than previously assumed, given the diminished population of surviving neurones in which these alterations appear. Both tangles and granulovacuoles demonstrated a stronger propensity for occurring in the posterior half of the hippocampus in demented patients' brains. This would not have been predicted from the relative distribution of neuronal loss in the two halves. The posterior portion of the hippocampus may be considerably more susceptible to the degenerative nerve cell changes prominent in dementia of the Alzheimer type.
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Previous studies helped establish the connection between amyloid-beta plaques, neurofibrillary tangles, and antemortem cognitive impairment.
“and previous studies that had also helped to establish the connection between AβPs, NFTs, and antemortem cognitive impairment (311-320).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [317]
Cites
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Walton, J. N. (1976) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(76)90157-x · Cited by 966 · see citing works
Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex
Brody, H. (1955) · The Journal of Comparative Neurology · doi:10.1002/cne.901020206 · Cited by 624 · see citing works
VARIATIONS IN THE HUMAN PURKINJE CELL POPULATION ACCORDING TO AGE AND SEX
HALL, T. C., MILLER, A. K. H., & Corsellis, J. (1975) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1975.tb00652.x · Cited by 225 · see citing works
Dayan, A. D. (1970) · Acta Neuropathologica · doi:10.1007/bf00687663 · Cited by 176 · see citing works
Handbuch der Geisteskrankheiten.
(1929) · JAMA · doi:10.1001/jama.1929.02700500059038 · Cited by 151 · see citing works
Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia.
Mehraein, P., Yamada, M., & Tarnowska-Dziduszko, E. (1975) · PubMed · Cited by 129 · see citing works
Shefer, V. F. (1973) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01182672 · Cited by 126 · see citing works
GRANULOVACUOLAR DEGENERATION IN THE AGEING BRAIN AND IN DEMENTIA
Ball, M. J., & LO, P. (1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197705000-00006 · Cited by 111 · see citing works
Self-citationDayan, A. D. (1970) · Acta Neuropathologica · doi:10.1007/bf00687664 · Cited by 105 · see citing works
NEUROFIBRILLARY TANGLES AND THE PATHOGENESIS OF DEMENTIA: A QUANTITATIVE STUDY
Ball, M. J. (1976) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1976.tb00513.x · Cited by 87 · see citing works
Self-citationSenile Degenerative Brain Lesions and Dementia
Morimatsu, M., Hirai, S., Muramatsu, A., & Yoshikawa, M. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00425.x · Cited by 86 · see citing works
The cerebral cortex in presenil dementia
Colon, E. J. (1973) · Acta Neuropathologica · doi:10.1007/bf00687457 · Cited by 71 · see citing works
CLINICOPATHOLOGIC SIGNIFICANCE OF GRANULOVACUOLAR DEGENERATION IN ALZHEIMERʼS DISEASE
Woodard, J. S. (1962) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196201000-00007 · Cited by 70 · see citing works
‘NEURONAL FALL-OUT’ IN THE AGEING BRAIN: A CRITICAL REVIEW OF THE QUANTITATIVE DATA
Hanley, T. (1974) · Age and Ageing · doi:10.1093/ageing/3.3.133 · Cited by 58 · see citing works
The elderly brain. A quantitative analysis in the cerebral cortex of two cases.
Ej, C. (1972) · PubMed · Cited by 56 · see citing works
Advances in neurology, Vol. 12. Physiology and pathology of dendrites
Ayala, G. F. (1976) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(76)90053-5 · Cited by 47 · see citing works
Flagged first, then by citations
1 of the 20 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Buée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,007 · see citing works
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · see citing works
Neural plasticity in the ageing brain
Burke, S. N., & Barnes, C. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1809 · Cited by 1,600 · see citing works
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
Gómez‐Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E., & Hyman, B. T. (1997) · Annals of Neurology · doi:10.1002/ana.410410106 · Cited by 1,489 · see citing works
The Clinical Diagnosis of Alzheimer's Disease
Wade, J. P. H., Mirsen, T. R., Hachinski, V. C., Fisman, M., Lau, C. S., & Merskey, H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130016010 · Cited by 1,416 · see citing works
Perl, D. P., & Brody, A. R. (1980) · Science · doi:10.1126/science.7367858 · Cited by 985 · see citing works
Brain atrophy in Alzheimer’s Disease and aging
Pini, L., Pievani, M., Bocchetta, M., Altomare, D., Bosco, P., Cavedo, E., Galluzzi, S., Marizzoni, M., & Frisoni, G. B. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.002 · Cited by 874 · see citing works
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772 · see citing works
Uchida, Y., Takio, K., Titani, K., Ihara, Y., & Tomonaga, M. (1991) · Neuron · doi:10.1016/0896-6273(91)90272-2 · Cited by 700 · see citing works
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
Killiany, R., Gómez‐Isla, T., Moss, M. B., Kikinis, R., Sándor, T., Jolesz, F. A., Tanzi, R. E., Jones, K. J., Hyman, B. T., & Albert, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 659 · see citing works
Age-Related Reductions in Human Recognition Memory Due to Impaired Encoding
Grady, C. L., McIntosh, A. R., Horwitz, B., Maisog, J. M., Ungerleider, L. G., Mentis, M. J., Pietrini, P., Schapiro, M. B., & Haxby, J. V. (1995) · Science · doi:10.1126/science.7618082 · Cited by 633 · see citing works
Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading
Brun, A., & Englund, E. M. (1981) · Histopathology · doi:10.1111/j.1365-2559.1981.tb01818.x · Cited by 559 · see citing works
Preclinical prediction of AD using neuropsychological tests
Albert, M., Moss, M. B., Tanzi, R. E., & JONES, K. (2001) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617701755105 · Cited by 517 · see citing works
Morris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513 · see citing works
Whittemore, S. R., & Seiger, Å. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90008-7 · Cited by 492 · see citing works
Cell loss in the hippocampus of schizophrenics
Falkai, P., & Bogerts, B. (1986) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00380943 · Cited by 487 · see citing works
Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473 · see citing works
Bobinski, M., de Leon, M. J., Wegiel, J., DeSanti, S., Convit, A., Saint Louis, L. A., Rusinek, H., & Wisniewski✠, H. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00476-5 · Cited by 455 · see citing works
Sjögren, M., Vanderstichele, H., Ågren, H., Zachrisson, O., Edsbagge, M., Wikkelsø, C., Skoog, I., Wallin, A., Wahlund, L.-O., Marcusson, J., et al. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.10.1776 · Cited by 436 · see citing works
A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA
Ball, M. J., Hachinski, V., Fox, A. J., Kirshen, A. J., Fisman, M., Blume, W. T., Kral, V. A., Fox, H., & Merskey, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90965-1 · Cited by 427 · see citing works
Self-citationHippocampal Pathologic Findings in Schizophrenia
Jeste, D. V. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110061009 · Cited by 427 · see citing works
Presynaptic Cholinergic Dysfunction in Patients with Dementia
Sims, N. R., Bowen, D. M., Allen, S. J., Smith, C., Neary, D., Thomas, D. J., & DAVISON, A. N. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb11311.x · Cited by 421 · see citing works
Epilepsy and Neuron Loss in the Hippocampus
Dam, A. M. (1980) · Epilepsia · doi:10.1111/j.1528-1157.1980.tb04315.x · Cited by 413 · see citing works
Spires, T. L., Orne, J. D., SantaCruz, K., Pitstick, R., Carlson, G. A., Ashe, K. H., & Hyman, B. T. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050840 · Cited by 401 · see citing works
Mora, F., Segovia, G., & Arco, A. D. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.03.011 · Cited by 401 · see citing works
Kaye, J. A., Swihart, T., Howieson, D., Dame, A., Moore, M. M., Karnos, T., Camicioli, R., Ball, M., Oken, B., & Sexton, G. (1997) · Neurology · doi:10.1212/wnl.48.5.1297 · Cited by 399 · see citing works
Self-citationSelkoe, D. J., Ihara, Y., & Salazar, F. J. (1982) · Science · doi:10.1126/science.6120571 · Cited by 394 · see citing works
Lütjohann, D., Papassotiropoulos, A., Björkhem, I., Locatelli, S., Bagli, M., Oehring, R. D., Schlegel, U. S., Jessen, F., Rao, M. L., von Bergmann, K., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32052-6 · Cited by 378 · see citing works
Temporal Lobe Regions on Magnetic Resonance Imaging Identify Patients With Early Alzheimer's Disease
Killiany, R., Moss, M. B., Albert, M., Sándor, T., Tieman, J., & Jolesz, F. A. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540090052010 · Cited by 371 · see citing works
Identification of nitrated proteins in Alzheimer’s disease brain using a redox proteomics approach
Sultana, R., Poon, H. F., Cai, J., Pierce, W. M., Merchant, M., Klein, J. B., Markesbery, W. R., & Butterfield, D. A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.10.004 · Cited by 364 · see citing works
Validation of clinical diagnostic criteria for Alzheimer's disease
Morris, J. C., McKeel, D. W., Fulling, K., Torack, R. M., & Berg, L. (1988) · Annals of Neurology · doi:10.1002/ana.410240105 · Cited by 362 · see citing works
Can disturbed brain microcirculation cause Alzheimer’s disease?
de la Torre, J. C., & Mussivan, T. (1993) · Neurological Research · doi:10.1080/01616412.1993.11740127 · Cited by 357 · see citing works
The car☐yl third of tau is tightly bound to paired helical filaments
Kondo, J., Honda, T., Mori, H., Hamada, Y., Miura, R., OGAWARA, M., & Ihara, Y. (1988) · Neuron · doi:10.1016/0896-6273(88)90130-4 · Cited by 355 · see citing works
Neurochemical Studies of Early-Onset Alzheimer's Disease
Francis, P. T., Palmer, A. M., Sims, N. R., Bowen, D. M., DAVISON, A. N., Esiri, M. M., Neary, D., Snowden, J. S., & Wilcock, G. K. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507043130102 · Cited by 353 · see citing works
Moloney, C. M., Lowe, V. J., & Murray, M. E. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12321 · Cited by 337 · see citing works
Moss, M. B., Albert, M., Butters, N., & Payne, M. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520030031008 · Cited by 332 · see citing works
ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?
Spillane, J. A., Curzon, G., Meier‐Ruge, W., White, P., Goodhardt, M., Iwangoff, P., DAVISON, A. N., & Bowen, D. M. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90454-9 · Cited by 327 · see citing works
Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type
Prinz, P. N., VITALIANO, P. P., Vitiello, M. V., Bokan, J. A., Raskind, M. A., Peskind, E. R., & Gerber, C. J. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90024-0 · Cited by 324 · see citing works
Aubert, I., Araujo, D. M., Cécyre, D., Robitaille, Y., Gauthier, S. G., & Quirion, R. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09752.x · Cited by 317 · see citing works
Geinisman, Y., deToledo‐Morrell, L., Morrell, F., & Heller, R. E. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00047-l · Cited by 317 · see citing works
Law, A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00051-5 · Cited by 312 · see citing works
Profile of Executive and Memory Function Associated with Amphetamine and Opiate Dependence
Ersche, K. D., Clark, L., London, M., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300889 · Cited by 311 · see citing works
Severity of symptoms in chronically institutionalized geriatric schizophrenic patients
Davidson, M., Harvey, P. D., Powchik, P., Parrella, M., WHITE, L. E., Knobler, H. Y., LOSONCZY, M. F., Keefe, R. S. E., Katz, S., & Frecska, E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.197 · Cited by 303 · see citing works
Amaral, D. G., & Insausti, R. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-547625-6.50026-x · Cited by 300 · see citing works
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
Clinton, L. K., Billings, L. M., Green, K. N., Caccamo, A., Ngo, J., Oddo, S., McGaugh, J. L., & LaFerla, F. M. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.06.013 · Cited by 299 · see citing works
Chen, X., & Mobley, W. C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00659 · Cited by 291 · see citing works
Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates
Ferrari, E., Cravello, L., Muzzoni, B., Casarotti, D., Paltro, M., Sb, S., Fioravanti, M., Cuzzoni, G., Pontiggia, B., & Magri, F. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440319 · Cited by 288 · see citing works
Bouras, C., Hof, P. R., Giannakopoulos, P., Michel, J.-P., & Morrison, J. H. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.2.138 · Cited by 280 · see citing works
Brain angiotensin receptor subtypes in the control of physiological and behavioral responses
Wright, J. W., & Harding, J. W. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90034-5 · Cited by 262 · see citing works
Memory: Anatomical Organization of Candidate Brain Regions
Amaral, D. G. (1987) · Comprehensive physiology · doi:10.1002/cphy.cp010507 · Cited by 262 · see citing works
Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus
Sullivan, E. V., Marsh, L., Mathalon, D. H., Lim, K. O., & Adolf Pfefferbaum, A. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00074-o · Cited by 256 · see citing works
Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins
Ihara, Y., Abraham, C. R., & Selkoe, D. J. (1983) · Nature · doi:10.1038/304727a0 · Cited by 254 · see citing works
The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system
LACOSTE, M. C. D., & White, C. L. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90015-4 · Cited by 252 · see citing works
Ball, M. J. (1978) · Acta Neuropathologica · doi:10.1007/bf00690970 · Cited by 251 · see citing works
Self-citationCreasey, H. M., & Rapoport, S. I. (1985) · Annals of Neurology · doi:10.1002/ana.410170103 · Cited by 250 · see citing works
Insausti, R., & Amaral, D. G. (2004) · Elsevier eBooks · doi:10.1016/b978-012547626-3/50024-7 · Cited by 246 · see citing works
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles
Hsiao, K., Dlouhy, S. R., Farlow, M. R., Cass, C., Costa, M. D., Conneally, P. M., Hodes, M. E., Ghetti, B. F., & Prusiner, S. B. (1992) · Nature Genetics · doi:10.1038/ng0492-68 · Cited by 245 · see citing works
Feature article: are neurons lost from the primate cerebral cortex during normal aging?
Peters, A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.4.295 · Cited by 245 · see citing works
“Limbic Predilection in Alzheimer Dementia: Is Reactivated Herpesvirus Involved?”
Ball, M. J. (1982) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100044115 · Cited by 243 · see citing works
Self-citationCognitive and neurobiologic markers of early Alzheimer disease
Albert, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13547 · Cited by 243 · see citing works
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90129-7 · Cited by 240 · see citing works
The Development of Amyloid β Protein Deposits in the Aged Brain
Thal, D. R., Capetillo-Zarate, E., Del Tredici, K., & Braak, H. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.6.re1 · Cited by 234 · see citing works
Emerging Concepts in Alzheimer's Disease
Vinters, H. V. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163927 · Cited by 232 · see citing works
DeKosky, S. T., Harbaugh, R. E., Schmitt, F. A., Bakay, R. A. E., Chui, H. C., Knopman, D. S., Reeder, T. M., Shetter, A. G., Senter, H. J., Markesbery, W. R., et al. (1992) · Annals of Neurology · doi:10.1002/ana.410320505 · Cited by 222 · see citing works
Goedert, M. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02694.x · Cited by 222 · see citing works
MRI and CSF studies in the early diagnosis of Alzheimer's disease
de Leon, M. J., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Segal, S., Clark, C. M., Kerkman, D. J., DeBernardis, J. F., Li, J., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01381.x · Cited by 221 · see citing works
Glucocorticoids Enhance Oxidative Stress-Induced Cell Death in Hippocampal Neurons in Vitro
Behl, C., Lezoualc’h, F., Trapp, T., Widmann, M., Skutella, T., & Holsboer, F. (1997) · Endocrinology · doi:10.1210/endo.138.1.4835 · Cited by 218 · see citing works
Köhler, S., Black, S. E., Sinden, M., Szekely, C. A., Kidron, D., Parker, J. L., Foster, J. K., Moscovitch, M., Wincour, G., Szalai, J. P., et al. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(98)00017-7 · Cited by 216 · see citing works
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles
Andrade-Moraes, C. H., de Oliveira-Pinto, A. V., Castro-Fonseca, E., da Silva, C. G., Guimarães, D. M., Szczupak, D., Parente-Bruno, D. R., Carvalho, L. R. B., Polichiso, L., Valério‐Gomes, B., et al. (2013) · Brain · doi:10.1093/brain/awt273 · Cited by 213 · see citing works
Copernicus revisited: amyloid beta in Alzheimer's disease
Josepha, J. A. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00211-6 · Cited by 203 · see citing works
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
Haroutunian, V., Purohit, D. P., Perl, D. P., Marin, D., Khan, K., Lantz, M., Davis, K. L., & Mohs, R. C. (1999) · Archives of Neurology · doi:10.1001/archneur.56.6.713 · Cited by 201 · see citing works
Smith, M. A. (1998) · International review of neurobiology · doi:10.1016/s0074-7742(08)60607-8 · Cited by 201 · see citing works
Bell, M. A., & Ball, M. J. (1981) · Acta Neuropathologica · doi:10.1007/bf00690372 · Cited by 200 · see citing works
Self-citationThe Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology
Cotman, C. W., Poon, W. W., Rissman, R. A., & Blurton-Jones, M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.104 · Cited by 199 · see citing works
Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer's Disease
de Leon, M. J., Mosconi, L., Blennow, K., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Tsui, W., Louis, L. A. S., Sobanska, L., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.012 · Cited by 198 · see citing works
Rylett, R. J., Ball, M. J., & Colhoun, E. H. (1983) · Brain Research · doi:10.1016/0006-8993(83)90017-3 · Cited by 198 · see citing works
Self-citationIshii, K., Kawachi, T., Sasaki, H., Kono, A. K., Fukuda, T., KOJIMA, Y., & Mori, E. (2005) · PubMed Central · Cited by 192 · see citing works
Interactive Effects of Age and Hypertension on Volumes of Brain Structures
Strassburger, T. L., Lee, H.-C., Daly, E., Szczepanik, J. E., Krasuski, J., Mentis, M. J., Salerno, J. A., DeCarli, C. S., Schapiro, M. B., & Alexander, G. E. (1997) · Stroke · doi:10.1161/01.str.28.7.1410 · Cited by 191 · see citing works
Kril, J., Patel, S., Harding, A., & Halliday, G. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0477-5 · Cited by 190 · see citing works
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works
Phosphatidylserine and the human brain
Glade, M. J., & Smith, K. (2014) · Nutrition · doi:10.1016/j.nut.2014.10.014 · Cited by 185 · see citing works
Weiss, S., Pin, J., Sebben, M., Kemp, D. E., Sladeczek, F. A. J., Gabrion, J., & Bockaert, J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.7.2238 · Cited by 184 · see citing works
Esiri, M. M. (2007) · The Journal of Pathology · doi:10.1002/path.2089 · Cited by 183 · see citing works
Luca, M., Luca, A., & Calandra, C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/504678 · Cited by 177 · see citing works
Chen, X., & Mobley, W. C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00446 · Cited by 174 · see citing works
Hyman, B. T., Marzloff, K., Wenniger, J. J., Dawson, T. M., Bredt, D. S., & Snyder, S. H. (1992) · Annals of Neurology · doi:10.1002/ana.410320618 · Cited by 174 · see citing works
Giannakopoulos, P., Hof, P. R., Michel, J., Guimón, J., & Bouras, C. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00023-4 · Cited by 173 · see citing works
Does PTSD Impair Cognition Beyond the Effect of Trauma?
Qureshi, S. U., Long, M. E., Bradshaw, M. R., Pyne, J. M., Magruder, K. M., Kimbrell, T., Hudson, T. J., Jawaid, A., Schulz, P. E., & Kunik, M. E. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.1.16 · Cited by 170 · see citing works
LIPPA, A. S., Critchett, D. J., Ehlert, F. J., Yamamura, H. I., Enna, S. J., & Bartus, R. T. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90052-x · Cited by 168 · see citing works
Long-Term Neuropathological and Neurochemical Effects of Nucleus Basalis Lesions in the Rat
Arendash, G. W., Millard, W. J., Dunn, A. J., & Meyer, E. M. (1987) · Science · doi:10.1126/science.2890210 · Cited by 167 · see citing works
Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease
Rössler, M., Zarski, R., Bohl, J., & Ohm, T. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0475-7 · Cited by 164 · see citing works
Koper, M. J., Schoor, E. V., Ospitalieri, S., Vandenberghe, R. R., Vandenbulcke, M., Arnim, C. A. F. V., Tousseyn, T., Balusu, S., Strooper, B. D., & Thal, D. R. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02103-y · Cited by 164 · see citing works
Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats
Torre, J. C. D., Fortin, T., Park, G. A. S., Butler, K., Kozłowski, P., Pappas, B. A., de Socarraz, H., Saunders, J. K., & Richard, M. T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90132-s · Cited by 164 · see citing works
An overview of current concepts of Alzheimer's disease
Schneck, M. K., Reisberg, ., & Ferris, S. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.2.165 · Cited by 163 · see citing works
Wolf, H., Grunwald, M., Kruggel, F., Riedel-Heller, S. G., Angerhöfer, S., Hojjatoleslami, A., Hensel, A., Arendt, T., & Gertz, H.-J. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00238-4 · Cited by 157 · see citing works
Mishizen-Eberz, A. J., Rissman, R. A., Carter, T. L., Ikonomovic, M. D., Wolfe, B. B., & Armstrong, D. M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.09.016 · Cited by 156 · see citing works
Deprenyl (selegiline): the history of its development and pharmacological action
Knoll, J. E. (1983) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1983.tb01517.x · Cited by 155 · see citing works
- Authors
- Ball, M. J.
- Affiliations
- Western University (CA)
- Corresponding author
- Ball, M. J.
- Venue
- Acta Neuropathologica
- Published
- 1977
- Volume
- 37
- Issue
- 2
- Pages
- 111-118
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2885814572
- Cited by
- 639
- References
- 20
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 3 · 2022: 14 · 2021: 7 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 11
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuronal loss, neurofibrillary tangles, granulovacuolar degeneration, hippocampus, Alzheimer's disease, dementia, normal aging, pyramidal neurons, medial temporal lobe, posterior hippocampus, neuronal density
- MeSH terms
- Aged, Aging, Alzheimer Disease, Cell Count, Dementia, Hippocampus, Humans, Middle Aged, Nerve Degeneration, Neurofibrils, Neurons
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