The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease
Open accessAbstract
Aims: To study the expression of mucins in peripheral airways in patients with chronic obstructive pulmonary disease (COPD). Methods and results: Peripheral lung sections from smokers with COPD (n = 9) and age‐matched controls including smokers (n = 11) and lifelong non‐smokers with normal lung function (n = 6) were stained with alcian blue, periodic acid–Schiff (PAS) and by immunohistochemistry of mucins (MUC): MUC2, MUC4, MUC5AC, MUC5B and MUC6. Histochemical staining and immunoreactivity of bronchiolar epithelium were graded and the presence or absence of stained mucus in the bronchiolar lumen was evaluated. There were no differences in alcian blue and PAS epithelial staining between the three groups. Intraluminal PAS staining was significantly more frequent among COPD subjects (P < 0.05). The expression of MUC5AC was significantly higher in the bronchiolar epithelium of patients with COPD (P < 0.05). Within the bronchiolar lumen, the predominant mucin was MUC5B. Intraluminal MUC5B was significantly more frequent among COPD patients (P < 0.05). Conclusions: COPD is specifically associated with increased expression of MUC5B in the bronchiolar lumen and of the mucin MUC5AC in the bronchiolar epithelium. These changes in mucin production in the peripheral airways may contribute to the pathophysiology of COPD.
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Cites
Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430407 · Cited by 1,078
Self-citationAirway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia
Rose, M. C., Nickola, T. J., & Voynow, J. A. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.5.f218 · Cited by 157
Cited by
Physicochemical properties of mucus and their impact on transmucosal drug delivery
Leal, J., Smyth, H. D. C., & Ghosh, D. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.018 · Cited by 560
Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways
Okuda, K., Chen, G., Subramani, D. B., Wolf, M., Gilmore, R. C., Kato, T., Radicioni, G., Kesimer, M., Chua, M., Dang, H., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0734oc · Cited by 293
Cellular and Molecular Biology of Airway Mucins
(2013) · International Review of Cell and Molecular Biology · doi:10.1016/b978-0-12-407697-6.00004-0 · Cited by 189
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin‐induced lung injury
Cortijo, J., Iranzo, A., Milara, X., Mata, M., Cerdá‐Nicolás, M., Ruiz‐Saurí, A., Tenor, H., Hatzelmann, A., & Morcillo, E. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00041.x · Cited by 114
Lee, S. U., Sung, M. H., Ryu, H. W., Lee, J., Kim, H.-S., In, H. J., Ahn, K.-S., Lee, H.-J., Lee, H.-K., Shin, D.-H., et al. (2016) · Cytokine · doi:10.1016/j.cyto.2015.08.262 · Cited by 58
Metadata
- Authors
- Caramori, G., Di Gregorio, C., Carlstedt, I., Casolari, P., Guzzinati, I., Adcock, I. M., Barnes, P. J., Ciaccia, A., Cavallesco, G., Chung, K. F., & Papi, A.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 2004-10-20
- Volume
- 45
- Issue
- 5
- Pages
- 477-484
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W2160067099
- Cited by
- 159
- References
- 2
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Caramori, G., Di Gregorio, C., Carlstedt, I., Casolari, P., Guzzinati, I., Adcock, I. M., Barnes, P. J., Ciaccia, A., Cavallesco, G., Chung, K. F., & Papi, A. (2004). Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. Histopathology. https://doi.org/10.1111/j.1365-2559.2004.01952.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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