Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia

Rose, Mary Callaghan; Nickola, Tracey J.; Voynow, Judith A.

doi:10.1165/ajrcmb.25.5.f218

Cited by 157Glycosylation and Glycoproteins ResearchAsthma and respiratory diseasesCystic Fibrosis Research Advances

Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia

Rose, Mary Callaghan, Nickola, Tracey J., Voynow, Judith A.·2001·American Journal of Respiratory Cell and Molecular Biology

DOI 10.1165/ajrcmb.25.5.f218

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Abstract

The mucus layer that coats the airway epithelium provides a protective barrier against pathogenic and noxious agents and participates in the mucosal response to inflammation and infection. Airway mucus is composed of water, ions, lung secretions, serum protein transudates, and mucin glycoproteins (mucins). Mucins are the major components of mucus and the macromolecules that impart rheologic properties to airway mucus (1, 2). Airway mucus is overproduced in the upper and/or lower respiratory tracts during acute challenges and in chronic conditions (asthma, cystic fibrosis, bronchitis, and sinusitis), thereby contributing to mucus obstruction of the airways (3). Mucus obstruction is the culmination of several complex processes including mucin ( MUC ) gene regulation, mucin secretion and goblet cell hyperplasia (GCH) (Figure 1). Insight into each of these processes is limited; more detailed information about fundamental cellular mechanisms will be required to better understand their interrelationships. For example, pathogenic agents and inflammatory mediators initiate secretion of mucins (4–7) and sustain mucin production by increasing expression of mucin genes (8, 9). Nevertheless, each process has markedly different kinetics and their response to mediators likely involves different cellular signaling and pathways. The increasing availability of molecular probes for specific mucin genes and gene products is beginning to provide some insights into the pathogenesis of mucus overproduction. However, detailed information about the expression and regulation of respiratory tract mucins in specific disease entities is still incomplete. The report by Chen and colleagues (10) provides new information on altered expression of a specific mucin gene, MUC5B.

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Adherence of S. aureus and Bordetella pertussis to Hep-2 epithelial cells was found in greater quantities for cells infected with RSV than for noninfected cells.
“Adherence of S. aureus and Bordetella pertussis to Hep-2 (human epidermoid cancer) epithelial cells was found in greater quantities for cells infected with RSV than for noninfected cells (240, 241)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [241]

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古賀, 豪. (2020)
Perspective Airway Epithelium and Mucus Intracellular Signaling Pathways for Gene Expression and Secretion
Adler, K. B., & Li, Y. (2013)

Authors: Rose, M. C., Nickola, T. J., & Voynow, J. A.
Affiliations: Duke University (US)
ORCID: Voynow, Judith A.
Venue: American Journal of Respiratory Cell and Molecular Biology
Publisher: Oxford University Press (OUP)
Published: 2001-11-01
Volume: 25
Issue: 5
Pages: 533-537
ISSN: 1044-1549 (ISSN-L)
1535-4989
DOI: 10.1165/ajrcmb.25.5.f218
OpenAlex: W2168675532
Cited by: 157
References: 58
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 14
FWCI: 0.52
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Keywords: airway mucus, mucus obstruction, mucin glycoproteins, goblet cell hyperplasia, MUC5B, mucus overproduction, airway epithelium, respiratory inflammation, cystic fibrosis, asthma, bronchitis, sinusitis
MeSH terms: Airway Obstruction, Gene Expression Regulation, Glycoproteins, Humans, Hyperplasia, Mucins, Mucus, Goblet Cells, Respiratory Mucosa

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Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia

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