Chronic Obstructive Pulmonary Disease
Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by the progressive development of airflow limitation that is not fully reversible.1 The term COPD encompasses chronic obstructive bronchitis, with obstruction of small airways, and emphysema, with enlargement of air spaces and destruction of lung parenchyma, loss of lung elasticity, and closure of small airways. Chronic bronchitis, by contrast, is defined by the presence of a productive cough of more than three months' duration for more than two successive years. The cough is due to hypersecretion of mucus and is not necessarily accompanied by airflow limitation. However, there is some epidemiologic evidence that . . .
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In patients with COPD, the airways typically collapse when pleural pressure becomes positive, thereby preventing increased expiratory flow.
“However, in these patients, the airways typically collapse when the pleural pressure becomes positive, thereby preventing increased expiratory flow.33”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [33]
Cites
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Systemic oxidative stress in asthma, COPD, and smokers
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American thoracic society statement: occupational contribution to the burden of airway disease
(2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.167.5.787 · Cited by 874 · see citing works
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
Mizumura, K., Cloonan, S. M., Nakahira, K., Bhashyam, A. R., Cervo, M., Kitada, T., Glass, K., Owen, C. A., Mahmood, A., Washko, G. R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74985 · Cited by 611 · see citing works
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Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease
Agustí, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., & Busquets, X. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2108013 · Cited by 343 · see citing works
Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction
Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69636 · Cited by 307 · see citing works
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Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
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CXCR2 antagonists for the treatment of pulmonary disease
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Hansel, T. T., Kharitonov, S. A., Donnelly, L. E., Erin, E. M., Currie, M. G., Moore, W. M., Manning, P. T., Recker, D. P., & Barnes, P. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0633fje · Cited by 208 · see citing works
Self-citationPathogenesis of hyperinflation in chronic obstructive pulmonary disease
Saey, Gagnon, P., Guenette, J., Langer, D., Laviolette, L., Mainguy, V., Maltais, F., & Ribeiro, F. (2014) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s38934 · Cited by 180 · see citing works
Singh, B., Mielke, M. M., Parsaik, A. K., Cha, R. H., Roberts, R. O., Scanlon, P. D., Geda, Y. E., Christianson, T. J., Pankratz, V. S., & Petersen, R. C. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.94 · Cited by 143 · see citing works
Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells
Ballweg, K., Mutze, K., Königshoff, M., Eickelberg, O., & Meiners, S. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00180.2014 · Cited by 128 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“Lung features of COPD include both airway obstruction, currently used to diagnose the disease and the disruption of alveolar walls called emphysema [4].”
BackgroundBewley, M. A., Belchamber, K. B. R., Chana, K. K., Budd, R. C., Donaldson, G., Wedzicha, J. A., Brightling, C. E., Kilty, I., Donnelly, L. E., Barnes, P. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163139 · Cited by 64 · see citing works
Self-citationWagena, E. J., Kant, I., van Amelsvoort, L. G. P. M., Wouters, E. F. M., van Schayck, C. P., & Swaen, G. M. H. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000138127.00991.cf · Cited by 42 · see citing works
Luo, C.-S., Chi, C.-C., Fang, Y.-A., Liu, J.-C., & Lee, K.-Y. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2019-001155 · Cited by 39 · see citing works
- Authors
- Barnes, P. J.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Barnes, Peter J.
- ORCID
- Barnes, Peter J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-07-27
- Volume
- 343
- Issue
- 4
- Pages
- 269-280
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4292166591
- Cited by
- 1,078
- References
- 4
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 25 · 2021: 27 · 2020: 30 · 2019: 25 · 2018: 35 · 2017: 38 · 2016: 38 · 2015: 39 · 2014: 52 · 2013: 39 · 2012: 40
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- chronic obstructive pulmonary disease, airflow obstruction, chronic obstructive bronchitis, emphysema, small airway obstruction, lung parenchyma destruction, chronic productive cough, mucus hypersecretion
- MeSH terms
- Adrenal Cortex Hormones, Anti-Inflammatory Agents, Anti-Bacterial Agents, Bronchodilator Agents, Humans, Inflammation, Lung Diseases, Obstructive, Oxygen Inhalation Therapy, Endopeptidases, Risk Factors, Smoking Cessation, Oxidative Stress, Leukocyte Elastase
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