The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T‐cell subset
Open accessAbstract
Summary: CD4+ CD25+ T regulatory cells (T Reg), suppress antigen‐specific immune responses and are important for allograft tolerance. During pregnancy the mother tolerates an allograft expressing paternal antigens (the fetus) requiring substantial changes in immune regulation over a programmed period of time. We analysed whether immune‐suppressive T Reg cells were altered during pregnancy and therefore might play a part in this tolerant state. The presence of T Reg cells was assessed in the blood of 25 non‐pregnant, 63 pregnant and seven postnatal healthy women by flow cytometry. We observed an increase in circulating T Reg cells during early pregnancy, peaking during the second trimester and then a decline postpartum. Isolated CD25+ CD4+ cells expressed FoxP3 messenger RNA, a marker of T Reg cells, and suppressed proliferative responses of autologous CD4+ CD25– T cells to allogeneic dendritic cells. These data support the concept that normal pregnancy is associated with an elevation in the number of T Reg cells which may be important in maintaining materno‐fetal tolerance.
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Citations
Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Cited by
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Ngo, S. T., Steyn, F. J., & McCombe, P. A. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.004 · Cited by 1,074
Kourtis, A. P., Read, J. S., & Jamieson, D. J. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1213566 · Cited by 850
Immunology of placentation in eutherian mammals
Moffett, A., & Loke, C. (2006) · Nature Reviews Immunology · doi:10.1038/nri1897 · Cited by 836
The role of decidual immune cells on human pregnancy
Liu, S., Diao, L., Huang, C., Li, Y., Zeng, Y., & Kwak-Kim, J. Y. H. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.10.045 · Cited by 308
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling
Taylor, D. D., Akyol, S., & Gercel-Taylor, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1534 · Cited by 297
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Metadata
- Authors
- Somerset, D. A., Zheng, Y., Kilby, M. D., Sansom, D. M., & Drayson, M. T.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2004-04-16
- Volume
- 112
- Issue
- 1
- Pages
- 38-43
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W2099703022
- Cited by
- 777
- References
- 1
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Somerset, D. A., Zheng, Y., Kilby, M. D., Sansom, D. M., & Drayson, M. T. (2004). Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T‐cell subset. Immunology. https://doi.org/10.1111/j.1365-2567.2004.01869.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
