Pregnancy and Infection
Open accessAbstract
Pregnant women have an increased severity of infections with some organisms, including influenza virus, hepatitis E virus, herpes simplex virus, and malaria parasites. This review includes an update on immunologic alterations during pregnancy.
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Pregnant women are more vulnerable to infections because of their naturally suppressed immune system and are generally considered at increased risk for severe complications.
“The pregnant women are more vulnerable to infections because of their naturally suppressed immune system and are generally considered at increased risk for severe complications [ Kourtis AP et al., 2014 ].”
From MINDFULNESS-BASED COGNITIVE THERAPY ON ANXIETY OF PREGNANT WOMEN DURING THE COVID-19 OUTBREAK IN TEHRAN, IRAN (2025) · cites this paper as Kourtis AP et al., 2014
The Future Directions section says pregnant women do not seem more susceptible to initial infection in general. The immunologic-alterations section rejects the view of pregnancy as systemic immunosuppression, describing it instead as a modulated immune condition. The paper does report increased severity for certain infections, but not the claim's general explanation of vulnerability. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe relative suppression of T cell responses that occurs at the end of pregnancy increases the severity of infection with influenza and varicella zoster viruses.
“The relative suppression of T cell responses that occurs at the end of pregnancy increases the severity of infection with influenza and varicella zoster viruses39.”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [39]
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- Authors
- Kourtis, A. P., Read, J. S., & Jamieson, D. J.
- Affiliations
- Centers for Disease Control and Prevention (US)
- University of California, San Francisco (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-06-05
- Volume
- 370
- Issue
- 23
- Pages
- 2211-2218
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4459512
- OpenAlex
- W2093544337
- Cited by
- 850
- References
- 69
- Citations by year
- 2026: 49 · 2025: 53 · 2024: 65 · 2023: 80 · 2022: 101 · 2021: 126 · 2020: 112 · 2019: 66 · 2018: 42 · 2017: 52 · 2016: 45 · 2015: 36 · 2014: 20 · 2013: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lincoln Repository (University of Lincoln) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (CC999999)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- pregnancy, infection in pregnancy, influenza virus, hepatitis E virus, herpes simplex virus, Plasmodium
- MeSH terms
- Communicable Diseases, Female, Herpes Simplex, Humans, Influenza, Human, Listeriosis, Malaria, Pregnancy, Pregnancy Complications, Infectious, Severity of Illness Index, Hepatitis E
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