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Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes
Open accessAbstract
Summary: In this study we analysed the effects of age on T and B lymphocytes in human lymph nodes by comparing lymphocyte subsets in paraffin sections from lymph node tissue taken from healthy young and elderly people. We demonstrate that the relative number of CD8+ T cells decreases with age but that the relative number of CD4+ T cells does not. There is also a very pronounced age‐dependent loss of CD45RA+ naïve T cells. The number and size of follicles and the relative number of CD20+ B cells are similar in young and elderly donors. For polymerase chain reaction analysis of the T‐cell receptor (TCR) repertoire the TCR‐γ gene rearrangements were used as a marker of clonality. This is a reliable tool to detect not only clonal TCR‐γδ populations but also TCR‐αβ populations. Young donors with clonal T‐cell expansions in their lymph node tissue do, however, have a higher number of CD20+ B cells, a higher relative size of germinal centres compared to the follicle mantles and a higher number of immunoglobulin M‐expressing cells than young donors without evidence of clonal T‐cell expansions. Corresponding changes are not observed in elderly donors with clonal T‐cell expansions in their lymph node tissue. In summary our findings demonstrate characteristic effects of aging on human lymph node tissue, the most striking feature being the depletion of naïve T cells and the apparent dysregulation of T‐cell/B‐cell interactions in old age.
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“These changes can include an involuted thymus235, fewer naive B and T cells236, diminished T cell receptor diversity237, higher susceptibility to T cell apoptosis238 and reduced expression of crucial receptors such as CD28 on cytotoxic CD8+ T cells239.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [236]
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Metadata
- Authors
- Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B.
- Affiliations
- Austrian Academy of Sciences (AT)
- Innsbruck Medical University (AT)
- Corresponding author
- Grubeck‐Loebenstein, Beatrix
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2004-12-16
- Volume
- 114
- Issue
- 1
- Pages
- 37-43
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W2074259682
- Cited by
- 263
- References
- 29
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 17 · 2023: 23 · 2022: 15 · 2021: 14 · 2020: 13 · 2019: 14 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 10 · 2013: 20 · 2012: 5
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- immunosenescence, aging, naive T cells, CD45RA, CD8+ T cells, CD4+ T cells, T cell-B cell interaction, lymph nodes, TCR gamma gene rearrangement, T cell clonal expansion, germinal center, follicles, B cells, immunoglobulin M
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Cell Division, Child, Child, Preschool, Clone Cells, Female, Humans, Immunoglobulin G, Infant, Lymph Nodes, Lymphocyte Cooperation, Lymphocyte Activation, Male, T-Lymphocytes, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes
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