Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
Abstract
Although it is generally recognized that the function of the immune system declines with age, the nature of the underlying defects is still poorly understood. We now demonstrate the predominance of CD8+CD28− T cell clonal expansions in elderly persons who fail to produce specific Abs following influenza vaccination. These clones express effector cell markers and are mostly CD45RA+. When isolated and put into culture, they are unable to proliferate, but produce IFN-γ (but no IL-5) upon stimulation with anti-CD3 or autoantigen. These autoreactive CD8+ type 1 effector cells seem to trigger a Th1 polarization, as CD4+ T cells from elderly persons without in vivo Ab production produce Th1, but only low amounts of Th2 cytokines upon in vitro stimulation with PHA. Therefore, the increased occurrence of CD8+CD28− clonal expansions may be decisive for the development of immune deficiency in the elderly.
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Frequencies of CD8+ TEMRA cells, many reactive to CMV, inversely predict antibody response to trivalent influenza vaccination.
“frequencies of CD8+ TEMRA cells, many of them reactive to CMV, inversely predicted the antibody response to trivalent influenza vaccination (TIV)”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Saurwein-Teissl et al., 2002
Cites
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287 · see citing works
The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature
Gross, P. A., Hermogenes, A. W., Sacks, H. S., Lau, J., & Levandowski, R. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-7-199510010-00008 · Cited by 1,100 · see citing works
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002 · see citing works
Nichol, K. L., Margolis, K. L., Wuorenma, J., & Sternberg, T. V. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409223311206 · Cited by 995 · see citing works
Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713 · see citing works
Detmar, M. J., Brown, L. F., Schön, M. P., Elicker, B. M., Velasco, P., Richard, L., Fukumura, D., Monsky, W. L., Claffey, K. P., & Jain, R. K. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00262.x · Cited by 550 · see citing works
Altered cytokine production in the elderly
Rink, L., Cakman, I., & Kirchner, H. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00153-x · Cited by 378 · see citing works
Monteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376 · see citing works
Blasko, I., Marx, F., Steiner, E., Hartmann, T., & Grubeck-Loebenstein, B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.63 · Cited by 278 · see citing works
Self-citationSpaulding, C., Guo, W., & Effros, R. B. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00033-9 · Cited by 258 · see citing works
The aging of the immune system
Grubeck-Loebenstein, B., & Wick, G. (2002) · Advances in immunology · doi:10.1016/s0065-2776(02)80017-7 · Cited by 235 · see citing works
Self-citationUnexpected expansions of CD8-bearing cells in old mice.
Callahan, J. E., Kappler, J. W., & Marrack, P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.12.6657 · Cited by 228 · see citing works
The Effect of Age on the B-Cell Repertoire
Weksler, M. E., & Szabo, P. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006659401385 · Cited by 205 · see citing works
Fitzgerald, J. E., Ricalton, N. S., Meyer, A. C., West, S., Kaplan, H. J., Behrendt, C. E., & Kotzin, B. L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.7.3538 · Cited by 203 · see citing works
Schirmer, M., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.1018 · Cited by 191 · see citing works
Immunity to influenza in the elderly
Webster, R. G. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00507-1 · Cited by 188 · see citing works
The Role of Cellular Senescence in Skin Aging
Campisi, J. (1998) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1998.2 · Cited by 177 · see citing works
Bandrés, E., Merino, J., Vázquez, B., Inogés, S., Moreno, C., Subirá, M. L., & Sánchez-Ibarrola, A. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4894 · Cited by 174 · see citing works
Wack, A. (1998) · International Immunology · doi:10.1093/intimm/10.9.1281 · Cited by 173 · see citing works
Nociari, M., Telford, W. G., & Russo, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3327 · Cited by 154 · see citing works
Grubeck‐Loebenstein, B., Trieb, K., Sztankay, A., et al. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117289 · Cited by 149 · see citing works
Self-citationAnti‐Inflammatory Drugs in the Fight against Alzheimer's Diseasea
McGeer, P. L., & McGeer, E. G. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34421.x · Cited by 123 · see citing works
Altered Th1/Th2 commitment in human CD4+ T cells with ageing
Sakata-Kaneko, S., Wakatsuki, Y., Matsunaga, Y., Usui, T., & Kita, T. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01224.x · Cited by 121 · see citing works
Cytokine production after influenza vaccination in a healthy elderly population
Bernstein, E. D. (1998) · Vaccine · doi:10.1016/s0264-410x(98)00140-6 · Cited by 112 · see citing works
Scheerens, H., Hessel, E. M., Malefyt, R. D. W., Leach, M. W., & Rennick, D. M. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200105)31:5 · Cited by 104 · see citing works
Wick, G., & Grubeck‐Loebenstein, B. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01037.x · Cited by 92 · see citing works
Self-citationCytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity
Catania, A. P., Airaghi, L., Motta, P., Manfredi, M. G., Annoni, G., Pettenati, C., Brambilla, F., & Lipton, J. M. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.b93 · Cited by 85 · see citing works
Distinct categories of immunologic changes in frail elderly
Fahey, J. L., Schnelle, J. F., Boscardin, W. J., Thomas, J. K., Gorre, M. E., Aziz, N., Sadeghi, H. M., & Nishanian, P. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00094-4 · Cited by 84 · see citing works
The Role of Cellular Senescence in Skin Aging
Campisi, J. (1998) · Journal of Investigative Dermatology · doi:10.1038/jidsp.1998.2 · Cited by 83 · see citing works
Costimulatory mechanisms in the elderly
Effros, R. B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00503-4 · Cited by 79 · see citing works
Miller, R. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.4.b180 · Cited by 74 · see citing works
Factors influencing serum neopterin and ?2-microglobulin levels in a healthy diverse population
Diamondstone, L. S., Tollerud, D. J., Fuchs, D., Wächter, H., Brown, L. M., Maloney, E. M., Kurman, C. C., Nelson, D. L., & Blattner, W. A. (1994) · Journal of Clinical Immunology · doi:10.1007/bf01546321 · Cited by 72 · see citing works
Mbawuike, I. N., Acuna, C. L., Walz, K. C., Atmar, R. L., Greenberg, S. B., & Couch, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01855-6 · Cited by 65 · see citing works
Grubeck‐Loebenstein, B., Berger, P., Saurwein-Teissl, M., Zisterer, K., & Wick, G. (1998) · Nature Medicine · doi:10.1038/nm0898-870b · Cited by 59 · see citing works
Self-citationBatliwalla, F., Rufer, N., Lansdorp, P. M., & Gregersen, P. K. (2000) · Human Immunology · doi:10.1016/s0198-8859(00)00157-9 · Cited by 59 · see citing works
Karanfilov, C. I., Beiqing, L., Fox, C. C., Lakshmanan, R. R., & Whisler, R. L. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00030-5 · Cited by 57 · see citing works
Steger, M. M., Maczek, C., Berger, P., & Grubeck‐Loebenstein, B. (1996) · The Lancet · doi:10.1016/s0140-6736(05)65680-2 · Cited by 57 · see citing works
Self-citationTumor necrosis factor α augments amyloid β protein (25–35) induced apoptosis in human cells
Blasko, I., Schmitt, T. L., Steiner, E., Trieb, K., & Grubeck‐Loebenstein, B. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00845-8 · Cited by 47 · see citing works
Self-citationViel, J. J., McManus, D. Q., Smith, S. S., et al. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1097 · Cited by 46 · see citing works
Is immune senescence reversible?
Beverley, P. C. L., & Grubeck-Loebenstein, B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00514-9 · Cited by 35 · see citing works
Self-citationMensink, A., Brouwer, A., van den Burg, E. H., et al. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00368-8 · Cited by 33 · see citing works
Saurwein-Teissl, M., Steger, M. M., Glück, R., Cryz, S. J., & Grubeck-Loebenstein, B. (1998) · Vaccine · doi:10.1016/s0264-410x(97)88329-6 · Cited by 15 · see citing works
Self-citationStulnig, T. M., Mair, A., Jarosch, E., Schober, M., Schönitzer, D., Wick, G., & Huber, L. A. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90143-f · Cited by 14 · see citing works
Retention of Radioactive Substances in the Body of Rats and the Lethal Dose
BHOUNEK, F., & Novák, F. (1937) · Nature · doi:10.1038/140106a0 · Cited by 4 · see citing works
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Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064 · see citing works
Gavazzi, G., & Krause, K.-H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00437-1 · Cited by 990 · see citing works
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works
Self-citationUnderstanding immunosenescence to improve responses to vaccines
Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827 · see citing works
The ageing haematopoietic stem cell compartment
Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604 · see citing works
Immunosenescence and human vaccine immune responses
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530 · see citing works
Effros, R. B., Fletcher, C. V., Gebo, K., Halter, J. B., Hazzard, W. R., Horne, F. M., Huebner, R. E., Janoff, E. N., Justice, A. C., Kuritzkes, D., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/590150 · Cited by 539 · see citing works
Strioga, M., Pasukoniene, V., & Characiejus, D. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03470.x · Cited by 505 · see citing works
T cell subset-specific susceptibility to aging
Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.12.002 · Cited by 478 · see citing works
Lin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426 · see citing works
Human immunosenescence: is it infectious?
Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405 · see citing works
Self-citationOsteoporosis, inflammation and ageing
Ginaldi, L., Di Benedetto, M. C., & De Martinis, M. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-14 · Cited by 412 · see citing works
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357 · see citing works
Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352 · see citing works
Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine · doi:10.1038/nm.2963 · Cited by 349 · see citing works
Human T Cell Aging and the Impact of Persistent Viral Infections
Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works
Immunosenescence: what does it mean to health outcomes in older adults?
McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works
The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Inflammaging as a prodrome to Alzheimer's disease
Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327 · see citing works
Exercise and the aging immune system
Simpson, R. J., Lowder, T. W., Spielmann, G., Bigley, A. B., LaVoy, E. C., & Kunz, H. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.003 · Cited by 281 · see citing works
Immunosenescence and vaccine failure in the elderly
Grubeck-Loebenstein, B., Della Bella, S., Iorio, A. M., Michel, J.-P., Pawelec, G., & Solana, R. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324904 · Cited by 269 · see citing works
Self-citationLazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02006.x · Cited by 263 · see citing works
Self-citationEffects of aging on T cell function
Haynes, L., & Maue, A. C. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.009 · Cited by 244 · see citing works
McElhaney, J. E., Zhou, X., Talbot, H. K., Soethout, E., Bleackley, R. C., Granville, D. J., & Pawelec, G. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.015 · Cited by 229 · see citing works
Deng, Y., Jing, Y., Campbell, A. E., & Gravenstein, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3437 · Cited by 230 · see citing works
Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223 · see citing works
Role of CMV in immune senescence.
Pawelec, G., & Derhovanessian, E. (2011) · Virus Research · doi:10.1016/j.virusres.2010.09.010 · Cited by 201 · see citing works
Aerobic fitness is associated with lower proportions of senescent blood T-cells in man
Spielmann, G., McFarlin, B. K., O’Connor, D. P., Smith, P. J. W., Pircher, H., & Simpson, R. J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.226 · Cited by 180 · see citing works
Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.
Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9499-x · Cited by 170 · see citing works
Self-citationImmunosenenescence: role of cytomegalovirus
Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163 · see citing works
van Duin, D., Allore, H. G., Mohanty, S., Ginter, S., Newman, F. K., Belshe, R. B., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Infectious Diseases · doi:10.1086/516788 · Cited by 159 · see citing works
Role of T lymphocyte replicative senescence in vaccine efficacy
Effros, R. B. (2007) · Vaccine · doi:10.1016/j.vaccine.2006.08.032 · Cited by 152 · see citing works
Frasca, D., Van der Put, E., Riley, R. L., & Blomberg, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2155 · Cited by 150 · see citing works
Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
Frasca, D., Diaz, A., Romero, M., Landin, A. M., Phillips, M., Lechner, S. C., Ryan, J. G., & Blomberg, B. B. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.10.023 · Cited by 143 · see citing works
. Persistent viral infections and immune aging.
Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143 · see citing works
Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stress
Effros, R. B. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.027 · Cited by 137 · see citing works
Weltevrede, M., Eilers, R., de Melker, H. E., & van Baarle, D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.005 · Cited by 128 · see citing works
Replicative senescence of CD8 T cells: Effect on human ageing
Effros, R. B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.024 · Cited by 127 · see citing works
Derhovanessian, E., Theeten, H., Hähnel, K., Van Damme, P., Cools, N., & Pawelec, G. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.11.041 · Cited by 121 · see citing works
Zhou, X., & McElhaney, J. E. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.029 · Cited by 106 · see citing works
Overcoming immune dysfunction in the elderly: trained immunity as a novel approach
Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99 · see citing works
Kaml, M., Weiskirchner, I., Keller, M., Luft, T., Hoster, E., Hasford, J., Young, L., Bartlett, B., Neuner, C., Fischer, K.-H., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.06.037 · Cited by 98 · see citing works
Self-citationDerhovanessian, E., Maier, A. B., Hähnel, K., McElhaney, J. E., Slagboom, E. P., & Pawelec, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303361 · Cited by 93 · see citing works
Parish, S. T., Wu, J. E., & Effros, R. B. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9449-7 · Cited by 85 · see citing works
Najarro, K., Nguyen, H., Chen, G., Xu, M., Alcorta, S., Yao, X., Zukley, L., Metter, E. J., Truong, T., Lin, Y., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv202 · Cited by 83 · see citing works
Molecular mechanisms of apoptosis in the cells of the immune system in human aging
Gupta, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00261.x · Cited by 85 · see citing works
Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection
Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00784 · Cited by 74 · see citing works
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77 · see citing works
Rizzo, L. B., Do Prado, C. H., Grassi-Oliveira, R., Wieck, A., Correa, B. L., Teixeira, A. L., & Bauer, M. E. (2013) · Bipolar Disorders · doi:10.1111/bdi.12121 · Cited by 73 · see citing works
How T follicular helper cells and the germinal centre response change with age
Linterman, M. A. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.77 · Cited by 69 · see citing works
Weinberger, B., Schirmer, M., Matteucci Gothe, R., Siebert, U., Fuchs, D., & Grubeck-Loebenstein, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082967 · Cited by 61 · see citing works
Self-citationMessaoudi, I., Fischer, M., Warner, J., Park, B., Mattison, J., Ingram, D. K., Totonchy, T., Mori, M., & Nikolich‐Žugich, J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00440.x · Cited by 57 · see citing works
Kleemeier Award Lecture 2008 – the canary in the coal mine: telomeres and human healthspan
Effros, R. B. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp001 · Cited by 58 · see citing works
Muller, G. C., Gottlieb, M. G. V., Luz Correa, B., Filho, I. G., Moresco, R. N., & Bauer, M. E. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.05.006 · Cited by 55 · see citing works
Derhovanessian, E., & Pawelec, G. (2012) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2011.00283.x · Cited by 51 · see citing works
Aging, cytomegalovirus (CMV) and influenza vaccine responses
Frasca, D., & Blomberg, B. B. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1105413 · Cited by 46 · see citing works
Fornara, O., Odeberg, J., Wolmer Solberg, N., Tammik, C., Skarman, P., Peredo, I., Stragliotto, G., Rahbar, A., & Söderberg-Nauclér, C. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1036211 · Cited by 45 · see citing works
Arnold, C. R., Pritz, T., Brunner, S., Knabb, C., Salvenmoser, W., Holzwarth, B., Thedieck, K., & Grubeck-Loebenstein, B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.018 · Cited by 42 · see citing works
Self-citationQuantity, not quality, of antibody response decreased in the elderly
Blomberg, B. B., & Frasca, D. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58406 · Cited by 34 · see citing works
- Authors
- Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., & Grubeck-Loebenstein, B.
- Affiliations
- Austrian Academy of Sciences (AT)
- Institute for Biomedical Aging Research of the Austrian Academy of Sciences, University Clinics Innsbruck , Innsbruck ,
- Innsbruck Medical University (AT)
- Institute of Pathophysiology, University Clinics Innsbruck , Innsbruck ,
- Central Institute for Blood Transfusion, University Clinics Innsbruck , Innsbruck ,
- Aventis-Pasteur , Marcy l’Etoile ,
- Corresponding author
- Marx, Florentine
- Asch, Esther
- Blasko, Imrich
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06-01
- Volume
- 168
- Issue
- 11
- Pages
- 5893-5899
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1576064052
- Cited by
- 499
- References
- 44
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 10 · 2023: 14 · 2022: 13 · 2021: 27 · 2020: 16 · 2019: 28 · 2018: 14 · 2017: 23 · 2016: 18 · 2015: 21 · 2014: 24 · 2013: 33 · 2012: 34
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Office of Naval Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- immunosenescence, CD8+CD28- T cells, T cell clonal expansion, influenza vaccination, antibody production, Th1/Th2 imbalance, interferon-gamma, IL-5, CD45RA, autoreactive T cells, T cell proliferation, CD4+ T cells
- MeSH terms
- Aged, Aged, 80 and over, Aging, Antibodies, Viral, Female, Humans, Influenza Vaccines, Male, Middle Aged, Vaccination, T-Lymphocyte Subsets, Cytokines, CD8 Antigens, CD28 Antigens, Th1 Cells, Th2 Cells
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