Cited by 499T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

Saurwein-Teissl, Maria, Lung, Thomas L, Marx, Florentine, Gschösser, Claudio, Asch, Esther, Blasko, Imrich, Parson, Walther, Böck, Günther +3 more·2002·The Journal of Immunology

Abstract

Although it is generally recognized that the function of the immune system declines with age, the nature of the underlying defects is still poorly understood. We now demonstrate the predominance of CD8+CD28− T cell clonal expansions in elderly persons who fail to produce specific Abs following influenza vaccination. These clones express effector cell markers and are mostly CD45RA+. When isolated and put into culture, they are unable to proliferate, but produce IFN-γ (but no IL-5) upon stimulation with anti-CD3 or autoantigen. These autoreactive CD8+ type 1 effector cells seem to trigger a Th1 polarization, as CD4+ T cells from elderly persons without in vivo Ab production produce Th1, but only low amounts of Th2 cytokines upon in vitro stimulation with PHA. Therefore, the increased occurrence of CD8+CD28− clonal expansions may be decisive for the development of immune deficiency in the elderly.

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Crossref · 10.4049/jimmunol.168.11.5893

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  • Frequencies of CD8+ TEMRA cells, many reactive to CMV, inversely predict antibody response to trivalent influenza vaccination.

    “frequencies of CD8+ TEMRA cells, many of them reactive to CMV, inversely predicted the antibody response to trivalent influenza vaccination (TIV)”

    From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Saurwein-Teissl et al., 2002

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Authors
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., & Grubeck-Loebenstein, B.
Affiliations
  • Austrian Academy of Sciences (AT)
  • Institute for Biomedical Aging Research of the Austrian Academy of Sciences, University Clinics Innsbruck , Innsbruck ,
  • Innsbruck Medical University (AT)
  • Institute of Pathophysiology, University Clinics Innsbruck , Innsbruck ,
  • Central Institute for Blood Transfusion, University Clinics Innsbruck , Innsbruck ,
  • Aventis-Pasteur , Marcy l’Etoile ,
Corresponding author
  • Marx, Florentine
  • Asch, Esther
  • Blasko, Imrich
Venue
The Journal of Immunology
Published
2002-06-01
Volume
168
Issue
11
Pages
5893-5899
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W1576064052
Cited by
499
References
44
Citations by year
2026: 5 · 2025: 9 · 2024: 10 · 2023: 14 · 2022: 13 · 2021: 27 · 2020: 16 · 2019: 28 · 2018: 14 · 2017: 23 · 2016: 18 · 2015: 21 · 2014: 24 · 2013: 33 · 2012: 34
FWCI
5.91
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Office of Naval Research
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
immunosenescence, CD8+CD28- T cells, T cell clonal expansion, influenza vaccination, antibody production, Th1/Th2 imbalance, interferon-gamma, IL-5, CD45RA, autoreactive T cells, T cell proliferation, CD4+ T cells
MeSH terms
Aged, Aged, 80 and over, Aging, Antibodies, Viral, Female, Humans, Influenza Vaccines, Male, Middle Aged, Vaccination, T-Lymphocyte Subsets, Cytokines, CD8 Antigens, CD28 Antigens, Th1 Cells, Th2 Cells

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