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Cited by 263T-cell and B-cell ImmunologyImmunotoxicology and immune responsesImmune Response and Inflammation

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes

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Lazuardi, Lutfan, Jenewein, Brigitte, Wolf, Anna Maria, Pfister, Gerald, Tzankov, Alexandar, Grubeck‐Loebenstein, Beatrix·2005·Immunology
DOI 10.1111/j.1365-2567.2004.02006.x
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Abstract

Summary: In this study we analysed the effects of age on T and B lymphocytes in human lymph nodes by comparing lymphocyte subsets in paraffin sections from lymph node tissue taken from healthy young and elderly people. We demonstrate that the relative number of CD8+ T cells decreases with age but that the relative number of CD4+ T cells does not. There is also a very pronounced age‐dependent loss of CD45RA+ naïve T cells. The number and size of follicles and the relative number of CD20+ B cells are similar in young and elderly donors. For polymerase chain reaction analysis of the T‐cell receptor (TCR) repertoire the TCR‐γ gene rearrangements were used as a marker of clonality. This is a reliable tool to detect not only clonal TCR‐γδ populations but also TCR‐αβ populations. Young donors with clonal T‐cell expansions in their lymph node tissue do, however, have a higher number of CD20+ B cells, a higher relative size of germinal centres compared to the follicle mantles and a higher number of immunoglobulin M‐expressing cells than young donors without evidence of clonal T‐cell expansions. Corresponding changes are not observed in elderly donors with clonal T‐cell expansions in their lymph node tissue. In summary our findings demonstrate characteristic effects of aging on human lymph node tissue, the most striking feature being the depletion of naïve T cells and the apparent dysregulation of T‐cell/B‐cell interactions in old age.

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Metadata

Authors
Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B.
Affiliations
  • Austrian Academy of Sciences (AT)
  • Innsbruck Medical University (AT)
Corresponding author
Grubeck‐Loebenstein, Beatrix
ORCID
Venue
Immunology
Publisher
Wiley
Published
2004-12-16
Volume
114
Issue
1
Pages
37-43
ISSN
  • 0019-2805 (ISSN-L)
  • 1365-2567
DOI
10.1111/j.1365-2567.2004.02006.x
OpenAlex
W2074259682
Cited by
263
References
29
Citations by year
2026: 11 · 2025: 8 · 2024: 17 · 2023: 23 · 2022: 15 · 2021: 14 · 2020: 13 · 2019: 14 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 10 · 2013: 20 · 2012: 5
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
immunosenescence, aging, naive T cells, CD45RA, CD8+ T cells, CD4+ T cells, T cell-B cell interaction, lymph nodes, TCR gamma gene rearrangement, T cell clonal expansion, germinal center, follicles, B cells, immunoglobulin M
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Cell Division, Child, Child, Preschool, Clone Cells, Female, Humans, Immunoglobulin G, Infant, Lymph Nodes, Lymphocyte Cooperation, Lymphocyte Activation, Male, T-Lymphocytes, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes

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