The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
Open accessAbstract
The vitamin D receptor (VDR) is a nuclear receptor expressed in a number of different cells of the immune system. This study was performed to determine the effect of VDR deficiency on immune function and inflammation of the gastrointestinal tract in a model of inflammatory bowel disease, namely interleukin-10 (IL-10) knockout mice. IL-10 knockout mice were generated which either could or could not respond to vitamin D (double IL-10/VDR knockout; DKO). The distribution and function of lymphocytes in both the primary and secondary lymphoid organs were compared and determined as a function of the severity of intestinal inflammation. DKO mice had normal thymic development and peripheral T-cell numbers at 3 weeks of age, but a week after intestinal disease was detected the thymus was dysplastic with a reduction in cellularity. The atrophy was coupled with increased apoptosis. The spleen weight of DKO mice increased as a result of the accumulation of red blood cells; however, there was a 50% reduction in the numbers of T and B cells. Conversely, the mesenteric lymph nodes were enlarged and contained increased numbers of lymphocytes. The T cells from DKO mice were of a memory phenotype and were hyporesponsive to T-cell receptor stimulation. Colitis in the DKO mice was associated with local and high expression of IL-2, interferon-gamma, IL-1beta, tumour necrosis factor-alpha and IL-12. The primary and secondary lymphoid organs in DKO mice are profoundly altered as a consequence of the fulminating inflammation in the gastrointestinal tract. VDR expression is required for the T cells and other immune cells to control inflammation in the IL-10 KO mice.
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“Taking 1 g of vitamin C or 533 mg of a-tocopherol before consuming a high-fat test meal blunted the acute CRP response to the meal (781) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [781]
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Metadata
- Authors
- Froicu, M., Zhu, Y., & Cantorna, M. T.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Cantorna, Margherita T.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2006-02-13
- Volume
- 117
- Issue
- 3
- Pages
- 310-318
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC1782241
- OpenAlex
- W2101825351
- Cited by
- 128
- References
- 30
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 11 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS038888)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- vitamin D receptor, IL-10 knockout mice, inflammatory bowel disease, colitis, intestinal immunity, thymic atrophy, T cell hyporesponsiveness, mesenteric lymph nodes, lymphocyte distribution, secondary lymphoid organs, cytokine expression, thymic apoptosis
- MeSH terms
- Animals, Atrophy, Colon, Disease Models, Animal, Flow Cytometry, Lymphoid Tissue, Mice, Inbred C57BL, Thymus Gland, Inflammatory Bowel Diseases, T-Lymphocyte Subsets, Cytokines, Interleukin-10, Apoptosis, Receptors, Calcitriol, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice
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