Cited by 448Vitamin D Research StudiesT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 158 of the 160 references it cites were found in a registry or an index.

Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator

Open access
Di Rosa, Michelino, Malaguarnera, Michele, Nicoletti, Ferdinando, Malaguarnera, Lucia·2011·Immunology

Abstract

The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)(2) D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.

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Crossref · 10.1111/j.1365-2567.2011.03482.x

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  1. Heine, 2002, 1,25-dihydroxy1,25(OH)2D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro, Eur J Immunol, 32, 3395
  2. Rook, 1986, 1,25(OH)2D3, γ interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes, Immunology, 57, 159
  3. Daniel, 2008, Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T cell Profile, J Pharmacol Exp Ther, 324, 23, 10.1124/jpet.107.127209 · DOI

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Metadata

Authors
Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L.
Affiliations
University of Catania (IT)
Corresponding author
Malaguarnera, Lucia
Venue
Immunology
Publisher
Wiley
Published
2011-09-06
Volume
134
Issue
2
Pages
123-139
ISSN
0019-2805 (ISSN-L)
OpenAlex
W1579451442
Cited by
447
References
160
Citations by year
2026: 14 · 2025: 16 · 2024: 27 · 2023: 44 · 2022: 39 · 2021: 44 · 2020: 54 · 2019: 34 · 2018: 26 · 2017: 29 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 30
FWCI
3.07
Type
journal article
Language
en
Open access
Locations
  • Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
vitamin D3, 1,25-dihydroxyvitamin D3, immunomodulation, immune regulation, innate immunity, adaptive immunity, calcium homeostasis, parathyroid hormone, vitamin D metabolism, inflammatory diseases, immune-mediated diseases, immune cell differentiation
MeSH terms
Animals, Bacterial Infections, Calcitriol, Humans, Immunity, Cellular, Virus Diseases, Mice, Immunomodulation

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