The DOI matches its Crossref record; 158 of the 160 references it cites were found in a registry or an index.
Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator
Open accessAbstract
The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)(2) D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.
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“Furthermore, UV can elicit the synthesis of vitamin D, an important molecule in calcium homeostasis of various types of skin cells contributing to DNA repair and immunomodulation.”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [86]
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“Intriguingly, local 1,25(OH)2D3 synthesis activates innate immune responses, but suppresses adaptive immune responses [86].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [86]
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Cites
2 retracted
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RetractedRETRACTED: 1α,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene
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RetractedToll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
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Nuclear Receptors and Lipid Physiology: Opening the X-Files
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Research works printed but not linked: 3
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Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 612
de Haan, K., Groeneveld, A. B. J., de Geus, H. R. H., Egal, M., & Struijs, A. (2014) · Critical Care · doi:10.1186/s13054-014-0660-4 · Cited by 301
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Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283
Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271
Metadata
- Authors
- Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L.
- Affiliations
- University of Catania (IT)
- Corresponding author
- Malaguarnera, Lucia
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2011-09-06
- Volume
- 134
- Issue
- 2
- Pages
- 123-139
- ISSN
- 0019-2805 (ISSN-L)
- PMC
- PMC3194221
- OpenAlex
- W1579451442
- Cited by
- 447
- References
- 160
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 27 · 2023: 44 · 2022: 39 · 2021: 44 · 2020: 54 · 2019: 34 · 2018: 26 · 2017: 29 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 30
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- vitamin D3, 1,25-dihydroxyvitamin D3, immunomodulation, immune regulation, innate immunity, adaptive immunity, calcium homeostasis, parathyroid hormone, vitamin D metabolism, inflammatory diseases, immune-mediated diseases, immune cell differentiation
- MeSH terms
- Animals, Bacterial Infections, Calcitriol, Humans, Immunity, Cellular, Virus Diseases, Mice, Immunomodulation
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