Spermatogenesis in Snell Dwarf Little and Congenitally Hypothyroid Mice
Open accessAbstract
The status of spermatogenesis in Snell dwarf, little and congenitally hypothyroid mice was studied. In all of these mice with a hormone deficiency the seminiferous tubules were smaller in size and contained fewer spermatogonia, spermatocytes, spermatids and spermatozoa than did those of normal control mice. There was no substantial difference in the Johnsen score between the hormone-deficient mice and normal control mice, but the former had underdeveloped seminiferous tubules with a corresponding paucity of germ cells, which may be partly responsible for the infertility of these mice. In the present study, growth hormone and thyroxine were administered separately to growth hormone-deficient and thyroxine-deficient mice, respectively. Such replacement therapy brought about an increase in cell counts of the seminiferous tubules and in sperm counts in both groups.
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In GH-deficient Snell dwarf mice, seminiferous tubules are underdeveloped and germ cells are reduced, resulting in infertility.
“In the GH deficient Snell dwarf mice, seminiferous tubules are underdeveloped and germ cells are reduced, resulting in infertility (11).”
From Growth Hormone Is Beneficial for Induction of Spermatogenesis in Adult Patients With Congenital Combined Pituitary Hormone Deficiency (2022) · cites this paper as [11]
The Results report that Snell dwarf mice have smaller seminiferous tubules and fewer germ cells than controls. The Results also say these abnormalities may be partly responsible for infertility; the claim’s unqualified “resulting in infertility” overstates that causal conclusion. (LLM, conf=0.88)
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“In the GH deficient Snell dwarf mice, seminiferous tubules are underdeveloped and germ cells are reduced, resulting in infertility (11).”
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Endocrine Causes of Infertility in the Male
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- Authors
- Matsushima, M., Kuroda, K., Shirai, M., Ando, K., Sugisaki, T., & Noguchi, T.
- Affiliations
- Toho University (JP)
- Corresponding author
- Noguchi, Tetsuya
- ORCID
- Shirai, Masafumi
- Venue
- International Journal of Andrology
- Publisher
- Wiley
- Published
- 1986-04
- Volume
- 9
- Issue
- 2
- Pages
- 132-140
- ISSN
- 0105-6263 (ISSN-L)
- 1365-2605
- OpenAlex
- W1998317247
- Cited by
- 17
- References
- 21
- Citations by year
- 2024: 1 · 2022: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Andrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- spermatogenesis, Snell dwarf mice, congenital hypothyroidism, growth hormone deficiency, thyroxine deficiency, seminiferous tubules, germ cells, infertility, hormone replacement therapy, sperm count
- MeSH terms
- Animals, Hypopituitarism, Hypothyroidism, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Organ Size, Seminiferous Tubules, Growth Hormone, Spermatogenesis, Testis, Thyroxine, Mice
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