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A positive role for the superoxide anion in triggering hyperactivation and capacitation of human spermatozoa
Abstract
Summary: Capacitation of human spermatozoa is essential for fertilization, and is characterized visually by hyperactivated motility. We have investigated whether reactive oxygen species could induce these two events in human spermatozoa. The addition of xanthine + xanthine oxidase + catalase (X+XO+CAT: generation of superoxide anion and removal of hydrogen peroxide) and foetal cord serum (FCS), a known biological inducer of capacitation and hyperactivation, to spermatozoa, induced levels of hyperactivation (15.4 ± 1.6% and 8.0 ± 1.0%, respectively) which were significantly higher than that of controls (5.4 ± 0.6%). The hyperactivation measured was part of the capacitation process. Furthermore, the addition of superoxide dismutase prevented the capacitation and hyperactivation induced by X+XO+CAT or by FCS. These results suggest that the superoxide anion may be involved in capacitation and hyperactivation of human spermatozoa.
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Citations
Cited by
Impacts of Oxidative Stress and Antioxidants on Semen Functions
Bansal, A. K., & Bilaspuri, G. S. (2011) · Veterinary Medicine International · doi:10.4061/2011/686137 · Cited by 756
Reactive oxygen species and sperm physiology
de Lamirande, E. (1997) · Reviews of Reproduction · doi:10.1530/revreprod/2.1.48 · Cited by 685
Self-citationReactive oxygen species and sperm cells
Sanocka, D., & Kurpisz, M. (2004) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-2-12 · Cited by 607
de Lamirande, E., & Gagnon, C. (1995) · Human Reproduction · doi:10.1093/humrep/10.suppl_1.15 · Cited by 566
Self-citationCauses and consequences of oxidative stress in spermatozoa
Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J., & Gharagozloo, P. (2015) · Reproduction, Fertility and Development · doi:10.1071/rd15325 · Cited by 428
Metadata
- Authors
- Lamirande, E. D., & Gagnon, C.
- Venue
- International Journal of Andrology
- Publisher
- Wiley
- Published
- 1993-02
- Volume
- 16
- Issue
- 1
- Pages
- 21-25
- ISSN
- 0105-6263 (ISSN-L)
- 1365-2605
- OpenAlex
- W1975010325
- Cited by
- 305
- References
- 0
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lamirande, E. D., & Gagnon, C. (1993). A positive role for the superoxide anion in triggering hyperactivation and capacitation of human spermatozoa. International Journal of Andrology. https://doi.org/10.1111/j.1365-2605.1993.tb01148.x
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