Human gastrointestinal nematode infections: are new control methods required?

Stepek, Gillian; Buttle, David J.; Duce, Ian R.; Behnke, Jerzy M.

doi:10.1111/j.1365-2613.2006.00495.x

Cited by 140Parasites and Host InteractionsHelminth infection and controlParasitic Diseases Research and Treatment

Human gastrointestinal nematode infections: are new control methods required?

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Stepek, Gillian, Buttle, David J., Duce, Ian R., Behnke, Jerzy M.·2006·International Journal of Experimental Pathology

DOI 10.1111/j.1365-2613.2006.00495.xPMC PMC2517378

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Abstract

Summary: Gastrointestinal (GI) nematode infections affect 50% of the human population worldwide, and cause great morbidity as well as hundreds of thousands of deaths. Despite modern medical practices, the proportion of the population infected with GI nematodes is not falling. This is due to a number of factors, the most important being the lack of good healthcare, sanitation and health education in many developing countries. A relatively new problem is the development of resistance to the small number of drugs available to treat GI nematode infections. Here we review the most important parasitic GI nematodes and the methods available to control them. In addition, we discuss the current status of new anthelmintic treatments, particularly the plant cysteine proteinases from various sources of latex‐bearing plants and fruits.

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Authors: Stepek, G., Buttle, D. J., Duce, I. R., & Behnke, J. M.
Affiliations: University of Nottingham (GB)
University of Sheffield (GB)
Corresponding author: Behnke, Jerzy M.
ORCID: Stepek, Gillian
Duce, Ian R.
Behnke, Jerzy M.
Venue: International Journal of Experimental Pathology
Publisher: Wiley
Published: 2006-08-29
Volume: 87
Issue: 5
Pages: 325-341
ISSN: 0959-9673 (ISSN-L)
1365-2613
DOI: 10.1111/j.1365-2613.2006.00495.x
PMC: PMC2517378
OpenAlex: W1934141242
Semantic Scholar: e74951cfba2f2f6f7757d6b7a82480acfc619587
Cited by: 140
References: 135
Citations by year: 2026: 6 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 14 · 2021: 9 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 8
FWCI: 0.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Experimental Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Leverhulme Trust
Topics: Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Health Sciences › Veterinary › Small Animals › Helminth infection and control
Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords: gastrointestinal nematode infection, anthelmintic resistance, anthelmintic treatment, nematode control, developing countries, parasitic nematodes
MeSH terms: Animals, Anthelmintics, Cysteine Endopeptidases, Humans, Intestinal Diseases, Parasitic, Life Cycle Stages, Nematoda, Nematode Infections

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Human gastrointestinal nematode infections: are new control methods required?

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