The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Angiogenesis drives psoriasis pathogenesis
Open accessAbstract
Summary: Psoriasis pathogenesis is closely associated with disease‐inducing Th1 and Th17 cells. Yet, several studies suggest that aberrant keratinocyte or endothelial cell signalling significantly contributes to disease manifestation. Histological hallmarks of psoriatic skin include the infiltration of multiple immune cells, keratinocyte proliferation and increased dermal vascularity. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators like vascular endothelial growth factor, hypoxia‐inducible factors, angiopoietins and pro‐angiogenic cytokines, such as tumour necrosis factor (TNF), interleukin (IL)‐8 and IL‐17, are up‐regulated in psoriasis development. Contact‐ and mediator‐dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. Interestingly, many therapies target not only immune cells, but also protein structures of endothelial cells. Here we summarize the role of pro‐angiogenic factors in psoriasis development and discuss angiogenesis as a potential target of novel therapies.
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Cites
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Cited by
Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis
Ghoreschi, K., Balato, A., Enerbäck, C., & Sabat, R. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00184-7 · Cited by 668
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Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
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Angiogenesis in Chronic Inflammatory Skin Disorders
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Metadata
- Authors
- Heidenreich, R., Röcken, M., & Ghoreschi, K.
- Venue
- International Journal of Experimental Pathology
- Publisher
- Wiley
- Published
- 2009-05-11
- Volume
- 90
- Issue
- 3
- Pages
- 232-248
- ISSN
- 0959-9673 (ISSN-L)
- 1365-2613
- OpenAlex
- W1782747004
- Cited by
- 383
- References
- 161
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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