Angiogenesis in Chronic Inflammatory Skin Disorders
Open accessAbstract
Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angiogenesis is deeply involved in the pathogenesis of psoriasis. VEGF, angiopoietins, tumor necrosis factor-a, interleukin-8, and interleukin-17 are unregulated in psoriasis and induce angiogenesis. Angiogenesis may be involved in the pathogenesis of atopic dermatitis, and in particular, mast cells are a major source of VEGF expression. Angiogenesis is an essential process in rosacea, which is induced by LL-37 from a signal cascade by microorganisms, VEGF, and MMP-3 from mast cells. In addition, angiogenesis by increased VEGF has been reported in chronic urticaria and hidradenitis suppurativa. The finding that VEGF is expressed in inflammatory skin lesions indicates that inhibition of angiogenesis is a useful strategy for treatment of chronic, inflammatory skin disorders.
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Increasing real-world evidence supports the durable efficacy and favorable long-term disease control achieved with selective IL-23 inhibitors.
“Increasing real-world evidence also supports the durable efficacy and favorable long-term disease control achieved with selective IL-23 inhibitors [27,28].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [28]
The Psoriasis section says anti-IL-23 treatments have proved more effective with fewer adverse events. It does not report real-world evidence or establish durable efficacy and long-term disease control for selective IL-23 inhibitors. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThroughout the psoriatic process, continuous exchange between keratinocytes and immune cells maintains a loop in which IL-23 sustains pathogenic T cells, IL-17 and IL-22 perpetuate epidermal alterations, and TNF-α amplifies inflammation across multiple cell types.
“Throughout this process, continuous exchange between keratinocytes and immune cells maintains a loop in which IL-23 sustains pathogenic T cells, IL-17 and IL-22 perpetuate epidermal alterations, and TNF-α amplifies inflammation across multiple cell types.”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [28]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredPsoriasis histopathological findings reflect activation of the IL-23/Th17 axis.
“These reflect activation of the IL-23/Th17 axis.”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [28]
The Psoriasis section (page not available) describes vascular changes in psoriatic lesions and says IL-17 from Th17 cells promotes angiogenesis. It also mentions effective anti-IL-23 treatments, but does not state that the histopathological findings reflect activation of an IL-23/Th17 axis. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn psoriasis, histopathological findings include acanthosis, parakeratosis, neutrophilic microabscesses, and prominent dermal vascular proliferation.
“In psoriasis, histopathological findings include acanthosis, parakeratosis, neutrophilic microabscesses, and prominent dermal vascular proliferation.”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [28]
Section 3 (Psoriasis; page not provided) describes epidermal hyperplasia and microvascular proliferation in psoriatic lesions, supporting the epidermal-thickening and vascular parts of the claim. It does not describe parakeratosis or neutrophilic microabscesses as histopathological findings; its mention of neutrophils concerns cytokine secretion. (LLM, conf=0.89)
Experimental — accuracy not yet measuredIn severe or refractory psoriasis, systemic agents such as methotrexate, cyclosporine, and acitretin broadly suppress immune activation and keratinocyte turnover, but their long-term use is limited by toxicity and lack of pathway specificity.
“In severe or refractory cases, systemic agents such as methotrexate, cyclosporine, and acitretin are used to broadly suppress immune activation and keratinocyte turnover, but their long-term use is limited by toxicity and lack of pathway specificity [28].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [28]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
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Pathological angiogenesis: mechanisms and therapeutic strategies
Dudley, A. C., & Griffioen, A. W. (2023) · Angiogenesis · doi:10.1007/s10456-023-09876-7 · Cited by 529 · see citing works
“Since these processes induce the expression of VEGF, which leads to the expansion of the dermal microvasculature [207, 208], it has been postulated that inhibition of angiogenesis might be a promising treatment approach.”
The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346 · see citing works
“One of the histological hallmarks of psoriatic skin is increased dermal vascularity [287].”
BackgroundSkin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties
Baker, P., Huang, C. Y., Radi, R., Moll, S., Jules, E., & Arbiser, J. L. (2023) · Cells · doi:10.3390/cells12232745 · Cited by 199 · see citing works
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Advances in 3D skin bioprinting for wound healing and disease modeling
Zhang, M., Zhang, C., Li, Z., Fu, X., & Huang, S. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac105 · Cited by 111 · see citing works
“Changes of the vascular system also contribute to the development of many skin diseases, especially autoimmune diseases and skin tumors [169, 170].”
Vitiligo, from Pathogenesis to Therapeutic Advances: State of the Art
Diotallevi, F., Gioacchini, H., SIMONI, E. D., Marani, A., Candelora, M., Paolinelli, M., Molinelli, E., Offidani, A., & Simonetti, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054910 · Cited by 102 · see citing works
Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies
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Characteristics and pathogenesis of Koebner phenomenon
Zhang, X., Li, L., Jiang, L., Fu, C., Huang, J., Hu, Y., Zhu, L., Zhang, F., Chen, J., & Zeng, Q. (2022) · Experimental Dermatology · doi:10.1111/exd.14709 · Cited by 81 · see citing works
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“64,65 Conversely, inhibiting DNMT1 modulates the Ang-1/NF-κ B signaling pathway to promote angiogenesis and accelerate diabetic wound healing.”
BackgroundEffects of RNA methylation on Tumor angiogenesis and cancer progression
Han, M., Sun, H., Zhou, Q., Liu, J., Hu, J., Yuan, W., & Sun, Z. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01879-8 · Cited by 59 · see citing works
Platelet Rich Plasma in the Repair of Articular Cartilage Injury: A Narrative Review
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Signaling pathways and targeted therapy for rosacea
Yang, F., Wang, L., Song, D., Zhang, L., Wang, X., Du, D., & Jiang, X. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1367994 · Cited by 54 · see citing works
The application and research progress of anti-angiogenesis therapy in tumor immunotherapy
Tu, J., Liang, H., Li, C., Huang, Y., Wang, Z., Chen, X., & Yuan, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1198972 · Cited by 53 · see citing works
“During the regulation of angiogenesis, multiple protein cytokines may act as activators of inflammatory and immune responses at elevated concentrations, thus causing pathological tumor angiogenesis (43, 95).”
BackgroundPoto, R., Loffredo, S., Palestra, F., Marone, G., Patella, V., & Varricchi, G. (2022) · Cells · doi:10.3390/cells11101720 · Cited by 47 · see citing works
“Angiogenesis, a term coined by John Hunter in 1787, is the outgrowth and proliferation of capillaries from pre-existing blood vessels [2,3].”
BackgroundVascularized 3D Human Skin Models in the Forefront of Dermatological Research
Rimal, R., Muduli, S., Desai, P., Marquez, A. B., Möller, M., Platzman, I., Spatz, J., & Singh, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303351 · Cited by 46 · see citing works
Targeting DNA methylation and demethylation in diabetic foot ulcers
Deng, J., Wu, X., He, W., Liao, X., Tang, M., & Nie, X. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.01.009 · Cited by 44 · see citing works
Molinelli, E., Gioacchini, H., Sapigni, C., Diotallevi, F., Brisigotti, V., Rizzetto, G., Offidani, A., & Simonetti, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098428 · Cited by 34 · see citing works
Tang, S., Hu, H., Li, M., Zhang, K., Wu, Q., Liu, X., Wu, L., Yu, B., & Chen, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1285951 · Cited by 33 · see citing works
Shi, C., Pei, S., Ding, Y., Tao, C., Zhu, Y., Peng, Y., Li, W., & Yi, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-34418-y · Cited by 32 · see citing works
S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
Saito‐Sasaki, N., & Sawada, Y. (2023) · Diagnostics · doi:10.3390/diagnostics13203167 · Cited by 31 · see citing works
“Angiogenesis is an essential component of the pathophysiology of inflammatory skin diseases; vascular alterations occur early in the onset of psoriasis [58].”
BackgroundShen, S., Wang, S., Wang, L., Sun, B., Zhang, Y., Zhang, Y., Jia, R., Yang, W., Chen, X., Cao, K., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101795 · Cited by 30 · see citing works
“This induces the proliferation and migration of endothelial cells, stimulates neo-vascularization, and enhances the sensitivity of vascular endothelial cells to VEGF, accelerating neovascularization and promoting the occurrence and progression of psoriasis [45].”
Exosomal miRNAs in autoimmune skin diseases
Zhang, R., Wei, Y., Wang, T., Nie, X., Shi, Z., Deng, Y., & Li, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1307455 · Cited by 27 · see citing works
SIMONI, E. D., Candelora, M., Belleggia, S., Rizzetto, G., Molinelli, E., Capodaglio, I., Ferretti, G., Bacchetti, T., Offidani, A., & Simonetti, O. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1393673 · Cited by 27 · see citing works
“Keratinocytes and mast cells have been shown to be a major source of vascular endothelial growth factor (VEGF) expression in AD; in fact, VEGF levels are elevated in the serum and skin of patients with AD compared with healthy controls (53–57).”
BackgroundUmehara, Y., Takahashi, M., Yue, H., Trujillo-Páez, J. V., Peng, G., Nguyen, H. L. T., Okumura, K., Ogawa, H., & Niyonsaba, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158800 · Cited by 27 · see citing works
“Angiogenesis, which is the formation of new blood vessels, is orchestrated by angiogenic factors and is an important process in development, as well as wound healing [11].”
BackgroundVascular Endothelial Growth Factor A VEGFA Inhibition: An Effective Treatment Strategy for Psoriasis
Chen, Y., Tai, Z., Zhu, C., Qin, Y., Zhu, Q., & Chen, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010059 · Cited by 29 · see citing works
Laschke, M. W., Gu, Y. J., & Menger, M. D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.981161 · Cited by 25 · see citing works
“, 2021) and chronic inflammatory skin disorders (Lee et al., 2021).”
BackgroundLoss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes
Shi, Y., Li, B., Huang, X., Kou, W., Zhai, M., Zeng, Y., You, S., Yu, Q., Zhao, Y., Zhuang, J., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-00960-5 · Cited by 24 · see citing works
Lee, Y. J., Yassa, C., Park, S.-H., Song, S. W., Jung, W. H., Lee, Y. W., Kang, H., & Kim, J. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076171 · Cited by 26 · see citing works
“Increased VEGF could promote the development of erythema by angiogenesis and the influx of inflammatory cells [50].”
BackgroundUnveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors?
Maia, J., Fonseca, B. M., Teixeira, N. A. A., & Correia‐da‐Silva, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115686 · Cited by 24 · see citing works
Photobiomodulation for melasma treatment: Integrative review and state of the art
Galache, T. R., Sena, M. M., Tassinary, J. A. F., & Pavani, C. (2023) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12935 · Cited by 23 · see citing works
“50,51 55 In one of these studies, half of the patients with phototype IV presented postinflammatory hyperchromia after treatment.”
BackgroundShen, S., Yan, G., Cao, Y., Zeng, Q., Zhao, J., Wang, X., & Wang, P. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114091 · Cited by 22 · see citing works
Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach
Galluccio, G., D’Onghia, M., Malvaso, D., Lazzeri, L., Cinotti, É., Rubegni, G., Rubegni, P., & Calabrese, L. (2024) · Cosmetics · doi:10.3390/cosmetics11010011 · Cited by 23 · see citing works
Applications of Engineered Skin Tissue for Cosmetic Component and Toxicology Detection
Wang, M., Zhang, L., Hao, H., Yan, M., & Zhu, Z. (2024) · Cell Transplantation · doi:10.1177/09636897241235464 · Cited by 23 · see citing works
“Vascular growth factors play an important role in all stages of wound healing, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), TGF, angio-poietin, and many other growth factors 117 .”
BackgroundKokai, D., Stanić, B., Tesic, B., Nenadov, D. S., Pogrmic‐Majkic, K., Nedeljković, S. F., & Andric, N. L. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110174 · Cited by 20 · see citing works
Guo, Y.-C., Gan, H., Xu, S., Zeng, G., Xiao, L., Ding, Z., Zhu, J., Xiong, X., & Fu, Z. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s417954 · Cited by 19 · see citing works
“Angiogenesis is a significant aspect of psoriasis, and VEGFA is a crucial component of angiogenesis.(25) We therefore sliced the dorsal skin of each mice group at the conclusion of the experiment to investigate the distribution of blood vessels.”
BackgroundMetformin: A Potential Treatment for Acne, Hidradenitis Suppurativa and Rosacea
Cho, M., Woo, Y. R., Cho, S. H., Lee, J. D., & Kim, H. S. (2023) · Acta Dermato Venereologica · doi:10.2340/actadv.v103.18392 · Cited by 21 · see citing works
“However, excessive angiogenesis may play a role in various cutaneous diseases, including psoriasis, atopic dermatitis, rosacea, haemangiomas, melanoma, and non-melanoma skin cancer (32–34).”
In situ forming PLA and PLGA implants for the parenteral administration of Cannabidiol
Lozza, I., Martín‐Sabroso, C., Torres‐Suárez, A. I., & Fraguas‐Sánchez, A. I. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124468 · Cited by 19 · see citing works
Lenalidomide attenuates IMQ-induced inflammation in a mouse model of psoriasis
Jia, H.-Y., Qiu, H.-Y., Zhang, M., Hou, J., Zhou, M., & Wu, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113883 · Cited by 18 · see citing works
Yang, X., & Cai, M. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s413237 · Cited by 18 · see citing works
“44 IL-17 not only directly promotes angiogenesis and expansion but also stimulates the production of TNF-α, IL-1β, and IL-6, and coordinates with IL-1β and TNF-α to upregulate other angiogenic factors, such as vascular endothelial growth factor and IL-8.”
BackgroundZhang, C., Jin, H., Kang, Y., Wu, Y., Zheng, R., Zhang, Z., Xu, H., Cai, W., Gao, X., Liu, H., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400006r · Cited by 17 · see citing works
“29 Moreover, these findings suggest that IL- 17A-neutralizing antibodies may inhibit LL- 37-induced angiogenesis in mice with rosacea-like conditions.”
Design Strategies and Application Potential of Multifunctional Hydrogels for Promoting Angiogenesis
Wang, M., Chen, J., Luo, Y., Feng, M., Yang, Q., Tang, Y., Tang, Z., Xiao, W., Zheng, Y., & Li, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s495971 · Cited by 16 · see citing works
The value of sonographic microvascular imaging in the diagnosis of lipedema
Kempa, S., Tessmann, V., Prantl, L., Schmid, S. A., Müller, M., Jung, E. M., & Tews, H. C. (2023) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-238103 · Cited by 16 · see citing works
The Role of Fibroblasts in Chronic Inflammatory and Proliferative Skin Diseases
Zang, R., Xu, C., Fan, Z., Wang, Q., Guo, Z., Liu, L., Cui, B., Huang, Y., & Yang, J. (2025) · Experimental Dermatology · doi:10.1111/exd.70066 · Cited by 15 · see citing works
“Although psoriasis is mainly driven by T-cells, its pathophysiology is greatly influenced by the dermal papillary vasculature, with the alkaline fibroblast factor in the dermis being one of the crucial angiogenic factors [46, 47].”
A state-of-the-art systematic review of cancer in hidradenitis suppurativa
Rached, N. A., Rüth, J., Gambichler, T., Ocker, L., & Bechara, F. G. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2382372 · Cited by 15 · see citing works
Treponema pallidum membrane protein Tp47 promotes angiogenesis through ROS ‐induced autophagy
Li, W., Xie, L., Li, Q., Xu, Q., Lin, L., Liu, L., & Yang, T. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18728 · Cited by 15 · see citing works
“However, excessive angiogenesis contributes to a number of pathologies, ranging from atherosclerosis, aneurysm and chronic inflammatory skin disorders.(28,29) In addition, pathological angiogenesis has been shown to be an important mode of transmission of various pathogens into the blood.”
BackgroundAgamia, N., Sorror, O. A., Sayed, N. M. E., Ghazala, R. A., Echy, S. M., Moussa, D. H., & Melnik, B. C. (2023) · Archives of Dermatological Research · doi:10.1007/s00403-023-02594-6 · Cited by 15 · see citing works
“Enhanced vascular endothelial growth factor (VEGF) expression has been reported in psoriasis and HS [59].”
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“[37] described that the VEGF concentrations correlated with the severity of AD as expressed by the SCORAD index.”
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“Studies have shown that angiogenesis is increased in the lesional skin of individuals with AD, and the increased blood vessel density and vascular permeability contribute to skin redness and edema observed in AD flare-ups [41].”
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“In addition, transforming growth factor (TGF)-β and platelet-derived growth factor (PDGF) have an effect on angiogenesis.(5) In inflamed tissues, lymphatic vessels are responsible for transporting soluble antigens and antigen-presenting cells to lymph nodes (LNs).”
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“Moreover, VEGF can interact with inflammatory mediators such as TNF-α and IL-1β, thereby exacerbating both the inflammatory response and vascular changes [97, 100–102].”
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“Since rosacea shares specific inflammation mechanisms with psoriasis and atopic dermatitis [37,38], we hypothesized that rosacea might also modify the protein composition in the GCF.”
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“47 In animal experiments, studies have shown that botulinum toxin can inhibit TLR2-mediated inflammation, 48 and reduce erythema induced by LL- 37-induced inflammation.”
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“9,10 Moreover, IL-17 enhances the activation of neurons in the inner frontal cortex, contributing to the development of anxiety and depression.”
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“Skin biopsy specimens obtained from active psoriatic lesions have indicated higher expression of VEGF-A compared to healthy skin of Ps patients and the skin of healthy people [121].”
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“A biological process known as Angiogenesis occurs when smooth muscle and endothelial cells migrate, proliferate, and sprout on top of pre-existing vessels to form new capillaries [4].”
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“The inhibition of VEGF receptor signaling is also used to treat inflammatory diseases in which angiogenesis plays a significant role, such as rheumatoid arthritis and psoriasis [32,33].”
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“While uncontrolled angiogenesis is linked to various pathological conditions, the physiologi - cal, well-controlled angiogenesis is vital for wound-healing and regeneration (Lee et al. 2021).”
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“The main pathological feature of psoriasis is the painful expansion of superficial dermal vessels with a clinical manifestation, such as the Auspitz sign [47].”
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“45 Several angiogenic mediators, including vascular endothelial growth factor, are highly expressed during psoriasis development.”
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“Interestingly, the inhibition of angiogenesis may therefore be an effective therapeutic approach to treating inflammatory skin disorders [11].”
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“Recent studies have emphasized the role of vascular endothelial growth factor in AD by promoting angiogenesis 124 .”
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“In addition, PGE2 activates the vascular endothelial growth factor (VEGF) pathway that induces angiogenesis and favors cellular proliferation, tumor growth, and metastasis [74].”
Background
- Authors
- Lee, H. J., Hong, Y. J., & Kim, M.
- Affiliations
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- Corresponding author
- Kim, Miri
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-11-07
- Volume
- 22
- Issue
- 21
- Pages
- 12035
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8584589
- OpenAlex
- W3212070111
- Cited by
- 211
- References
- 123
- Citations by year
- 2026: 31 · 2025: 63 · 2024: 55 · 2023: 43 · 2022: 19
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2018R1D1A1B07044100 and 2019R1F1A1059460)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- angiogenesis, chronic inflammatory skin disease, psoriasis, atopic dermatitis, rosacea, chronic urticaria, hidradenitis suppurativa, vascular endothelial growth factor, angiopoietins, mast cells, YAP/TAZ signaling, angiogenesis inhibition, IL-17, interleukin-8, TNF-α, LL-37, MMP-3
- MeSH terms
- Animals, Chronic Disease, Dermatitis, Dermatitis, Atopic, Humans, Neovascularization, Pathologic, Psoriasis, Rosacea, Vascular Endothelial Growth Factor A, Angiopoietins
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