In vivo transfer of pAMβ1 from Lactobacillus reuteri to Enterococcus faecalis
Abstract
Trials were conducted to determine the in vivo transferability of plasmid‐mediated antibiotic resistance between two strains of enteric Gram‐positive bacteria. Germfree mice were associated with the donor Lactobacillus reuteri DSM 20016 strain, carrying the broad host range pAMβ1 plasmid, and with the Enterococcus faecalis JH2SS recipient strain. Analysis of faecal content of associated mice demonstrated that the in vivo transfer of this plasmid did occur and that frequencies of conjugation were affected by the presence of subtherapeutic levels of antibiotic in the diet.
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In vivo transfer via conjugation of AR genes from viable probiotic bacteria acting as donors was documented in 1998 and several papers since have confirmed the transferability of AR genes within the gut.
“In vivo transfer via conjugation of AR genes from viable probiotic bacteria acting as donors was documented in 199833 and several papers since have confirmed the transferability of AR genes within the gut for a recent review see.34”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [33]
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- Authors
- Morelli, L., Sarra, P. G., & Bottazzi, V.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- ORCID
- Morelli, L.
- Venue
- Journal of Applied Bacteriology
- Publisher
- Wiley
- Published
- 1988-11
- Volume
- 65
- Issue
- 5
- Pages
- 371-375
- ISSN
- 0021-8847 (ISSN-L)
- OpenAlex
- W2113628171
- Cited by
- 71
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Bacteriology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- plasmid transfer, conjugation, Lactobacillus reuteri, Enterococcus faecalis, plasmid-mediated antibiotic resistance, germ-free mice, broad-host-range plasmids, fecal microbiota
- MeSH terms
- Spectinomycin, Animals, Conjugation, Genetic, DNA, Bacterial, Drug Resistance, Microbial, Electrophoresis, Agar Gel, Erythromycin, Feces, Germ-Free Life, Lactobacillus, Mice, Inbred C3H, R Factors, Enterococcus faecalis, Mice
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