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Cited by 754Antibiotic Resistance in BacteriaProbiotics and Fermented FoodsPharmaceutical and Antibiotic Environmental Impacts

Antibiotic resistance in food lactic acid bacteria—a review

Mathur, Shalini, Singh, Rameshwar·2005·International Journal of Food Microbiology
DOI 10.1016/j.ijfoodmicro.2005.03.008
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Abstract

Antibiotics are a major tool utilized by the health care industry to fight bacterial infections; however, bacteria are highly adaptable creatures and are capable of developing resistance to antibiotics. Consequently, decades of antibiotic use, or rather misuse, have resulted in bacterial resistance to many modern antibiotics. This antibiotic resistance can cause significant danger and suffering for many people with common bacterial infections, those once easily treated with antibiotics. For several decades studies on selection and dissemination of antibiotic resistance have focused mainly on clinically relevant species. However, recently many investigators have speculated that commensal bacteria including lactic acid bacteria (LAB) may act as reservoirs of antibiotic resistance genes similar to those found in human pathogens. The main threat associated with these bacteria is that they can transfer resistance genes to pathogenic bacteria. Genes conferring resistance to tetracycline, erythromycin and vancomycin have been detected and characterized in Lactococcus lactis, Enterococci and, recently, in Lactobacillus species isolated from fermented meat and milk products. A number of initiatives have been recently launched by various organizations across the globe to address the biosafety concerns of starter cultures and probiotic microorganisms. The studies can lead to better understanding of the role played by the dairy starter microorganisms in horizontal transfer of antibiotic resistance genes to intestinal microorganisms and food-associated pathogenic bacteria.

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Crossref · 10.1016/j.ijfoodmicro.2005.03.008

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  • Many resistance determinants identified in Bacillus probiotics are considered intrinsic chromosomal traits, and therefore their presence alone does not necessarily indicate horizontal gene transfer without further analysis of their genomic context.

    “However, many resistance determinants identified in Bacillus probiotics are considered intrinsic chromosomal traits, and therefore, their presence alone does not necessarily indicate horizontal gene transfer without further analysis of their genomic context.8,28”

    From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and <i>in vitro</i> assessment (2026) · cites this paper as [28]

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Authors
Mathur, S., & Singh, R.
Affiliations
National Dairy Research Institute (IN)
Corresponding author
Singh, Rameshwar
Venue
International Journal of Food Microbiology
Publisher
Elsevier BV
Published
2005-12
Volume
105
Issue
3
Pages
281-295
ISSN
0168-1605 (ISSN-L)
DOI
10.1016/j.ijfoodmicro.2005.03.008
OpenAlex
W2010360751
Cited by
754
References
139
Citations by year
2026: 29 · 2025: 26 · 2024: 38 · 2023: 53 · 2022: 34 · 2021: 52 · 2020: 62 · 2019: 44 · 2018: 42 · 2017: 48 · 2016: 38 · 2015: 48 · 2014: 43 · 2013: 36 · 2012: 47
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Food Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords
antibiotic resistance, lactic acid bacteria, foodborne bacteria, horizontal gene transfer, antibiotic resistance genes, Lactococcus lactis, Enterococcus, Lactobacillus, tetracycline resistance, erythromycin resistance, vancomycin resistance, fermented dairy products, fermented meat products, starter cultures, probiotics, biosafety
MeSH terms
Anti-Bacterial Agents, Conjugation, Genetic, Consumer Product Safety, Food Microbiology, Humans, Lactobacillus, Microbial Sensitivity Tests, Mutation, Gene Transfer, Horizontal, Drug Resistance, Bacterial

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