Tumour necrosis factor‐α in human adipose tissue – from signalling mechanisms to clinical implications
Abstract
Abstract.: From its initial implication in the development of cachexia in the early 1980s, it is now almost 15 years ago that tumour necrosis factor‐alpha (TNF‐α) was first shown to be involved in the development of insulin resistance in obesity. Since the original findings in mice, a wealth of data has been obtained in a variety of settings and species. This intensive research has demonstrated both similarities and differences between rodents and humans regarding the molecular mechanisms and metabolic consequences of TNF‐α overexpression. This review will focus on the role of TNF‐α in human white adipose tissue with particular emphasis on its regulation of lipolysis – an important pathway in adipocytes which is linked to insulin‐resistant phenotypes in obesity and the metabolic syndrome.
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TNF-α plays a direct role in metabolic syndrome via a direct effect on insulin signaling.
“Growing evidence suggests that TNF-α plays a direct role in metabolic syndrome, via direct effect of TNF-α on insulin signaling [35, 36].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [36]
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- Authors
- Rydén, M., & Arner, P.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Rydén, M.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2007-08-02
- Volume
- 262
- Issue
- 4
- Pages
- 431-438
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2043772361
- Cited by
- 118
- References
- 81
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 6
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- TNF-α, white adipose tissue, insulin resistance, obesity, lipolysis, adipocytes, cachexia, metabolic syndrome, TNF-alpha signalling
- MeSH terms
- Adipose Tissue, Blood Glucose, Cachexia, Cell Communication, Gene Expression Regulation, Humans, Insulin Resistance, Obesity, Tumor Necrosis Factor-alpha, Gene Expression
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