Cited by 118Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Tumour necrosis factor‐α in human adipose tissue – from signalling mechanisms to clinical implications

Rydén, M., Arner, P.·2007·Journal of Internal Medicine

Abstract

Abstract.: From its initial implication in the development of cachexia in the early 1980s, it is now almost 15 years ago that tumour necrosis factor‐alpha (TNF‐α) was first shown to be involved in the development of insulin resistance in obesity. Since the original findings in mice, a wealth of data has been obtained in a variety of settings and species. This intensive research has demonstrated both similarities and differences between rodents and humans regarding the molecular mechanisms and metabolic consequences of TNF‐α overexpression. This review will focus on the role of TNF‐α in human white adipose tissue with particular emphasis on its regulation of lipolysis – an important pathway in adipocytes which is linked to insulin‐resistant phenotypes in obesity and the metabolic syndrome.

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Crossref · 10.1111/j.1365-2796.2007.01854.x

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81 of 81 references verified0 citation errors · 0 not checkable

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  • TNF-α plays a direct role in metabolic syndrome via a direct effect on insulin signaling.

    “Growing evidence suggests that TNF-α plays a direct role in metabolic syndrome, via direct effect of TNF-α on insulin signaling [35, 36].”

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Authors
Rydén, M., & Arner, P.
Affiliations
Karolinska University Hospital (SE)
Corresponding author
Rydén, M.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2007-08-02
Volume
262
Issue
4
Pages
431-438
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W2043772361
Cited by
118
References
81
Citations by year
2026: 3 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 6
FWCI
1.69
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
TNF-α, white adipose tissue, insulin resistance, obesity, lipolysis, adipocytes, cachexia, metabolic syndrome, TNF-alpha signalling
MeSH terms
Adipose Tissue, Blood Glucose, Cachexia, Cell Communication, Gene Expression Regulation, Humans, Insulin Resistance, Obesity, Tumor Necrosis Factor-alpha, Gene Expression

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