The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mitochondrial dysfunction as a cause of ageing
Open accessAbstract
Abstract.: Mitochondrial dysfunction is heavily implicated in the ageing process. Increasing age in mammals correlates with accumulation of somatic mitochondrial DNA (mtDNA) mutations and decline in respiratory chain function. The age‐associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. Studies of mtDNA mutator mice has shown that increased levels of somatic mtDNA mutations directly can cause a variety of ageing phenotypes, such as osteoporosis, hair loss, greying of the hair, weight reduction and decreased fertility. Respiratory‐chain‐deficient cells are apoptosis prone and increased cell loss is therefore likely an important consequence of age‐associated mitochondrial dysfunction. There is a tendency to automatically link mitochondrial dysfunction to increased generation of reactive oxygen species (ROS), however, the experimental support for this concept is rather weak. In fact, respiratory‐chain‐deficient mice with tissue‐specific mtDNA depletion or massive increase of point mutations in mtDNA typically have minor or no increase of oxidative stress. Mitochondrial dysfunction is clearly involved in the human ageing process, but its relative importance for mammalian ageing remains to be established.
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Self-citationMitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy
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Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
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Senescence and aging: the critical roles of p53
Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789
Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
Fu, Z., R. Gilbert, E., & Liu, D. (2013) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 732
Extending life span by increasing oxidative stress
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Metadata
- Authors
- Trifunovic, A., & Larsson, N. ‐.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2008-01-21
- Volume
- 263
- Issue
- 2
- Pages
- 167-178
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2159840353
- Cited by
- 378
- References
- 27
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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