Cited by 106Lipoproteins and Cardiovascular HealthAcute Myocardial Infarction ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Relationships between lipoprotein components and risk of myocardial infarction: age, gender and short versus longer follow-up periods in the Apolipoprotein MOrtality RISk study (AMORIS)

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Holme, I., Aastveit, A. H., Jungner, I., Walldius, G.·2008·Journal of Internal Medicine

Abstract

OBJECTIVES: Examine and compare lipoprotein components associated with fatal and nonfatal acute myocardial infarction (AMI) by time period in the Apolipoprotein MOrtality RISk (AMORIS) Study. DESIGN: Prospective follow-up study of nonfatal and fatal myocardial infarction through linkage with Swedish hospital discharge and Swedish mortality registers. SETTING: Measurements of lipoprotein components from health check-ups in the larger Stockholm area. SUBJECTS: The AMORIS subjects (n = 149 121) free of AMI at blood sampling were followed from 1985 to 2002 with respect to n = 6794 first cases of AMI. RESULTS: Hazard ratios of nonfatal and fatal AMI by lipoprotein parameters were highly significant and about equally strong in both genders. Apolipoprotein B (apoB), nonhigh density cholesterol and low density cholesterol predicted nonfatal AMI (NFAMI) better than fatal AMI, but high density cholesterol or apolipoprotein A-1 did not. Atherogenic components were weaker predictors after 1997 than before. In multivariate analyses apoB/apoA-1 was a better predictor than TC/HDL-C. ApoB/apoA-1 added clinically significant information to TC/HDL-C in men as reflected by a net reclassification improvement (NRI) of 9.4% (P < 0.0001). CONCLUSION: ApoB, apoB/apoA-1 and non-HDL-C were found about equally predictive with LDL-C being slightly less, but multivariate analyses showed apoB/apoA-1 to be the strongest predictor. Attenuation of prediction ability between nonfatal and fatal AMI may be due to modern treatment of CHD after a NFAMI and attenuation of hazard ratios after 1997 may be due to selection of lower risk subjects surviving to 1997.

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Crossref · 10.1111/j.1365-2796.2008.01925.x

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Research works printed but not linked: 3

  1. Pedersen TR, Faergeman O, Kastelein JJ et al. High-dose ator- vastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized con- trolled trial. JAMA 2005; 294: 2437-45.
  2. Jungner I, Walldius G, Holme I, Kolar W, Steiner E. Apolipo- protein B and A-1 in relation to serum cholesterol and triglyce- rides in 43000 Swedish males and females. Int J Clin Lab Res 1992; 21: 247-55.
  3. Tikkanen MJ, Holme I, Faergeman O et al. ApoB ⁄ apoA-1 is as predictive as several conventional lipid risk factors combined in statin-treated patients. Eur Heart J Suppl. 2007; 28: S731.

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Authors
Holme, I., Aastveit, A. H., Jungner, I., & Walldius, G.
Affiliations
  • Oslo University Hospital (NO)
  • Norwegian University of Life Sciences (NO)
  • Karolinska Institutet (SE)
Corresponding author
Holme, I.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2008-06-28
Volume
264
Issue
1
Pages
30-38
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W1999515845
Cited by
106
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 4
FWCI
13.35
Type
journal article
Language
en
Open access
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fondation pour la Médecine de Laboratoire
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
acute myocardial infarction, apolipoprotein B, apolipoprotein A-I, non-HDL cholesterol, LDL cholesterol, HDL cholesterol, coronary heart disease risk prediction, net reclassification improvement, age and gender differences, follow-up duration
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Apolipoproteins B, Cholesterol, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Myocardial Infarction, Sex Factors, Sweden, Apolipoprotein A-I

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