Low-Density Lipoprotein, Non-High-Density Lipoprotein, and Apolipoprotein B as Targets of Lipid-Lowering Therapy
Abstract
lthough low-density lipoprotein (LDL) is widely recognized as the major atherogenic lipoprotein and the primary target of lipid-lowering therapy, 1 other lipoprotein species nonetheless appear to be involved in atherogenesis.These include very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and highdensity lipoproteins (HDL).Both VLDL and IDL are triglyceride-rich lipoproteins (TGRLP).Thus, in the aftermath of unequivocal evidence that LDL lowering reduces risk for major coronary events and stroke, 2 the field of lipid study is turning more of its attention to the other lipoproteins that appear to be involved in atherosclerosis.The recent Adult Treatment Panel III (ATP III) report 1 of the National Cholesterol Education Program has summarized our current understanding of the relationship between other lipoprotein species and risk for coronary heart disease (CHD).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated total apoB is a related potential secondary target; it reflects the number of atherogenic lipoproteins in circulation.
“A related and potential secondary target is an elevated total apoB 158 ; this measure denotes the number of atherogenic lipoproteins in circulation.”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [158]
Cites
(1997) · Archives of Internal Medicine · doi:10.1001/archinte.157.21.2413 · Cited by 6,345 · see citing works
(1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440420033005 · Cited by 3,777 · see citing works
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
Gordon, D. J., Probstfield, J. L., Garrison, R. J., Neaton, J. D., Castelli, W. P., Knoke, J. D., Jacobs, D. R., Bangdiwala, S., & Tyroler, H. A. (1989) · Circulation · doi:10.1161/01.cir.79.1.8 · Cited by 3,162 · see citing works
National Cholesterol Education Program
Lenfant, C. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400060019005 · Cited by 1,184 · see citing works
Hypertriglyceridemia as a cardiovascular risk factor
Austin, M. A., Hokanson, J. E., & Edwards, K. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00031-9 · Cited by 1,066 · see citing works
Hulley, S. B., Rosenman, R. H., Bawol, R. D., & Brand, R. J. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006193022503 · Cited by 702 · see citing works
Non–High-Density Lipoprotein Cholesterol Level as a Predictor of Cardiovascular Disease Mortality
Cui, Y. A., Blumenthal, R. S., Flaws, J. A., Whiteman, M. K., LANGENBERG, P. W., Bachorik, P. S., & Bush, T. L. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.11.1413 · Cited by 657 · see citing works
Management of Dyslipidemia in NIDDM
Garg, A., & Grundy, S. M. (1990) · Diabetes Care · doi:10.2337/diacare.13.2.153 · Cited by 260 · see citing works
Self-citationFibrinogen and coronary heart disease--what does it mean?
Assmann, G., Schulte, H., Funke, H., & von Eckardstein, A. (1998) · PubMed · Cited by 256 · see citing works
Atherogenicity of Triglyceride-Rich Lipoproteins
Krauss, R. M. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00032-0 · Cited by 227 · see citing works
Frost, P. H., & Havel, R. J. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00034-4 · Cited by 193 · see citing works
Bittner, V., Hardison, R., Kelsey, S. F., Weiner, B. H., Jacobs, A. K., & Sopko, G. (2002) · Circulation · doi:10.1161/01.cir.0000038496.57570.06 · Cited by 168 · see citing works
Cohn, J. S., Marcoux, C., & Davignon, J. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.10.2474 · Cited by 156 · see citing works
Serum Lipids and Incidence of Coronary Heart Disease
Frost, P. H., Davis, B. R., Burlando, A. J., Curb, J. D., Guthrie, G. P., Isaacsohn, J. L., Wassertheil-Smoller, S. W., Wilson, A. C., & Stamler, J. (1996) · Circulation · doi:10.1161/01.cir.94.10.2381 · Cited by 148 · see citing works
Cohen, Y., Raz, I., Merin, G., & Mozes, B. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00797-2 · Cited by 131 · see citing works
Cholesterol Lowering in the Elderly Population
Grundy, S. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.15.1670 · Cited by 123 · see citing works
Self-citationRemnant lipoproteins as therapeutic targets
Havel, R. J. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200012000-00008 · Cited by 107 · see citing works
Updated Guidelines for Cholesterol Management
Lauer, M. S. (2001) · JAMA · doi:10.1001/jama.285.19.2508 · Cited by 83 · see citing works
ABATEA, N., Vega, G., & Grundy, S. M. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90187-y · Cited by 76 · see citing works
Self-citationDoes measurement of apolipoprotein B have a place in cholesterol management?
Vega, G. L., & Grundy, S. M. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.5.668 · Cited by 64 · see citing works
Self-citationSniderman, A. D. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.8.1310 · Cited by 20 · see citing works
Schuff‐Werner, P., Schettler, V. J. J., & Schulz, E. (1999) · CRC Press eBooks · doi:10.1201/b15444 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 25 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Self-citationObesity, Metabolic Syndrome, and Cardiovascular Disease
Grundy, S. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0372 · Cited by 1,369 · see citing works
Self-citationWALLDIUS, G., & JUNGNER, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01643.x · Cited by 583 · see citing works
Barter, P. J., Ballantyne, C. M., Carmena, R., Cabezas, M. C., Chapman, M. J., Couture, P., Graaf, J. D., Durrington, P. N., Færgeman, O., Frohlich, J., et al. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01616.x · Cited by 463 · see citing works
Diagnosis and management of the metabolic syndrome
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000200416.65370.a0 · Cited by 434 · see citing works
Self-citationCromwell, W. C., Otvos, J. D., Keyes, M. J., Pencina, M. J., SULLIVAN, L. M., Vasan, R. S., Wilson, P. W. F., & D’Agostino, R. B. (2007) · Journal of clinical lipidology · doi:10.1016/j.jacl.2007.10.001 · Cited by 428 · see citing works
Walldius, G., & Jungner, I. (2004) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01276.x · Cited by 395 · see citing works
Association Among Rheumatoid Arthritis, Oral Hygiene, and Periodontitis
Pischon, N., Pischon, T., Kröger, J.-C., Gülmez, E., Kleber, B. M., Bernimoulin, J. ‐., Landau, H., Brinkmann, P. ‐., Schlattmann, P., Zernicke, J., et al. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.070501 · Cited by 387 · see citing works
Contois, J. H., McConnell, J. P., Sethi, A. A., Csako, G., Devaraj, S., Hoefner, D. M., & Warnick, G. R. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.118356 · Cited by 326 · see citing works
Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia
Stein, E. A., Dufour, R., Gagné, C., Gaudet, D., East, C. A., Donovan, J. M., Chin, W., Tribble, D. L., & McGowan, M. P. (2012) · Circulation · doi:10.1161/circulationaha.112.104125 · Cited by 297 · see citing works
Walldius, G., Jungner, I., AASTVEIT, A. H., Holme, I., Furberg, C. D., & Sniderman, A. D. (2004) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2004.254 · Cited by 287 · see citing works
Liu, J., Sempos, C. T., Donahue, R. P., Dorn, J., Trevisan, M., & Grundy, S. M. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.06.032 · Cited by 277 · see citing works
Self-citationDavidson, M. H., Ballantyne, C. M., Jacobson, T. A., Bittner, V. A., Braun, L. T., Brown, A. S., Brown, W. V., Cromwell, W. C., Goldberg, R. B., McKenney, J. M., et al. (2011) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.07.005 · Cited by 262 · see citing works
Low-Density Lipoprotein Size and Cardiovascular Disease: A Reappraisal
Sacks, F. M., & Campos, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030636 · Cited by 241 · see citing works
Liu, J., Sempos, C. T., Donahue, R. P., Dorn, J. P., Trevisan, M., & Grundy, S. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.1916 · Cited by 237 · see citing works
Self-citationJiang, R., Schulze, M. B., Li, T., Rifai, N., Stampfer, M. J., Rimm, E. B., & Hu, F. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1991 · Cited by 232 · see citing works
Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., García‐Almagro, F. J., Avilés-Plaza, F. V., Parra, S., Yáñez-Gascón, M. J., Ruiz‐Ros, J. A., García‐Conesa, M., Tomás-Barberán, F. A., et al. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100673 · Cited by 211 · see citing works
Twickler, T. B., Dallinga-Thie, G. M., Cohn, J. S., & Chapman, M. J. (2004) · Circulation · doi:10.1161/01.cir.0000125278.58527.f3 · Cited by 201 · see citing works
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
Backes, J., Anzalone, D., Hilleman, D., & Catini, J. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0286-4 · Cited by 195 · see citing works
Patton, H. M., Yates, K. P., Ünalp–Arida, A., Behling, C. A., Huang, T. T. ‐., Rosenthal, P. J., Sanyal, A. J., Schwimmer, J. B., & Lavine, J. E. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.152 · Cited by 185 · see citing works
New loci and coding variants confer risk for age-related macular degeneration in East Asians
Cheng, C., Yamashiro, K., Chen, L. J., Ahn, J., Huang, L., Huang, L., Cheung, C. M. G., Miyake, M., Cackett, P., Yeo, I. Y. S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7063 · Cited by 183 · see citing works
Ramjee, V., Sperling, L. S., & Jacobson, T. A. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.05.009 · Cited by 157 · see citing works
Incident Cardiovascular Disease Events in Metabolically Benign Obese Individuals
Ogorodnikova, A. D., Kim, M., McGinn, A. P., Muntner, P., Khan, U. I., & Wildman, R. P. (2011) · Obesity · doi:10.1038/oby.2011.243 · Cited by 146 · see citing works
Ezetimibe: cholesterol lowering and beyond
Bays, H. E., Neff, D., Tomassini, J. E., & Tershakovec, A. M. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.4.447 · Cited by 145 · see citing works
Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
Lathe, R., Tsitrina, A. A., & Kotelevtsev, Y. V. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-36 · Cited by 136 · see citing works
Frontini, M., Srinivasan, S. R., Xu, J.-H., Tang, R., Bond, M. G., & Berenson, G. S. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1472 · Cited by 136 · see citing works
López, N., Quintero, A., Casanova, P. A., Ibieta, C. I., Bælum, V., & López, R. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.110227 · Cited by 134 · see citing works
Targeting Low HDL-Cholesterol to Decrease Residual Cardiovascular Risk in the Managed Care Setting
Cziraky, M. J., Watson, K. E., & Talbert, R. L. (2008) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2008.14.s8-a.1 · Cited by 132 · see citing works
Separating extracellular vesicles and lipoproteins via acoustofluidics
Wu, M., Chen, C., Wang, Z., Bachman, H., Ouyang, Y., Huang, P., Sadovsky, Y., & Huang, T. J. (2019) · Lab on a Chip · doi:10.1039/c8lc01134f · Cited by 129 · see citing works
Volger, S., Vetter, M. L., Dougherty, M., Panigrahi, E., Egner, R., Webb, V., Thomas, J. G., Sarwer, D. B., & Wadden, T. A. (2011) · Obesity · doi:10.1038/oby.2011.217 · Cited by 122 · see citing works
Stroke mortality and the apoB/apoA‐I ratio: results of the AMORIS prospective study
Walldius, G., AASTVEIT, A. H., & Jungner, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01610.x · Cited by 122 · see citing works
Apolipoproteins as markers and managers of coronary risk
Chan, D. C. (2006) · QJM · doi:10.1093/qjmed/hcl027 · Cited by 117 · see citing works
Ballantyne, C. M., Bertolami, M. C., García, H. R. H., Nul, D. R., Stein, E. A., Théroux, P., Weiss, R., Cain, V. A., & Raichlen, J. S. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.12.013 · Cited by 112 · see citing works
Ren, J., Grundy, S. M., Liu, J., Wang, W., Wang, M., Sun, J., Liu, J., Li, Y., Wu, Z., & Zhao, D. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.02.020 · Cited by 111 · see citing works
Self-citationPhillips, C. M., Tierney, A. C., Pérez‐Martínez, P., Defoort, C., Blaak, E. E., Gjelstad, I. M. F., López‐Miranda, J., Kieć-Klimczak, M., Malczewska-Malec, M., Drevon, C. A., et al. (2013) · Obesity · doi:10.1002/oby.20263 · Cited by 110 · see citing works
Holme, I., Aastveit, A. H., Jungner, I., & Walldius, G. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01925.x · Cited by 106 · see citing works
Ballantyne, C. M., Raichlen, J. S., & Cain, V. A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.052 · Cited by 102 · see citing works
Johansson‐Persson, A., Ulmius, M., Cloetens, L., Karhu, T., Herzig, K., & Önning, G. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0496-8 · Cited by 100 · see citing works
Buse, J. B., Rubin, C. J., Frederich, R. C., Viraswami-Appanna, K., Lin, K.-C., Montoro, R. J., Shockey, G., & Davidson, J. A. (2005) · Clinical Therapeutics · doi:10.1016/j.clinthera.2005.08.005 · Cited by 99 · see citing works
Statins Are Underutilized in Patients with Nonalcoholic Fatty Liver Disease and Dyslipidemia
Blais, P., Lin, M. F., Kramer, J. R., El‐Serag, H. B., & Kanwal, F. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-4000-6 · Cited by 93 · see citing works
Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
Skulas-Ray, A. C., West, S. G., Davidson, M. H., & Kris-Etherton, P. M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.7.1237 · Cited by 91 · see citing works
Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12150 · Cited by 88 · see citing works
Walldius, G., & Jungner, I. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi077 · Cited by 88 · see citing works
Apolipoprotein Measurements: Is More Widespread Use Clinically Indicated?
Davidson, M. H. (2009) · Clinical Cardiology · doi:10.1002/clc.20559 · Cited by 87 · see citing works
Bigornia, S., Mott, M. M., Hess, D. T., Apovian, C. M., McDonnell, M. E., Duess, M., Kluge, M. A., Fiscale, A. J., Vita, J. A., & Gokce, N. (2010) · Obesity · doi:10.1038/oby.2009.482 · Cited by 80 · see citing works
Clinical Relevance of Non-HDL Cholesterol in Patients With Diabetes
Peters, A. L. (2008) · Clinical Diabetes · doi:10.2337/diaclin.26.1.3 · Cited by 78 · see citing works
Prevalence of the metabolic syndrome in Peruvian Andean hispanics: The PREVENCION study
Medina‐Lezama, J., Zea-Díaz, H., Morey‐Vargas, O. L., Bolaños-Salazar, J. F., Muñoz-Atahualpa, E., Dowall, M. P. M., Corrales‐Medina, F. F., Valdivia-Ascuña, Z., Cuba-Bustinza, C., Diaz, S. P., et al. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.04.004 · Cited by 76 · see citing works
Olofsson, S., Wiklund, O., & Borén, J. (2007) · PubMed Central · Cited by 73 · see citing works
Ford, N. D., Behrman, J. R., Hoddinott, J. F., Maluccio, J. A., Martorell, R., Ramírez‐Zea, M., & Stein, A. D. (2018) · The Lancet Global Health · doi:10.1016/s2214-109x(18)30231-6 · Cited by 71 · see citing works
LDL-C, NON-HDL-C and APO-B for cardiovascular risk assessment: Looking for the ideal marker
Aggarwal, D. J., Kathariya, G., & Verma, P. (2021) · Indian Heart Journal · doi:10.1016/j.ihj.2021.07.013 · Cited by 69 · see citing works
Association of Renal Resistive Index With Target Organ Damage in Essential Hypertension
Doi, Y., Iwashima, Y., Yoshihara, F., Kamide, K., Takata, H., Fujii, T., Kubota, Y., Nakamura, S., Horio, T., & Kawano, Y. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.113 · Cited by 68 · see citing works
Carrero, J. J., López‐Huertas, E., Salmerón, L. M., Baró, L., & Ros, E. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1393 · Cited by 67 · see citing works
Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics
Lee, R. G., Crosby, J. R., Baker, B. F., Graham, M. J., & Crooke, R. M. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9495-7 · Cited by 66 · see citing works
Therapeutic approaches to drug targets in hyperlipidemia
Mahamuni, S. P., Khose, R. D., Menaa, F., & Badole, S. L. (2012) · Biomedicine · doi:10.1016/j.biomed.2012.08.002 · Cited by 66 · see citing works
Sniderman, A. D. (2004) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000137220.39031.3b · Cited by 62 · see citing works
Eicosanoids and renal damage in cardiometabolic syndrome
Imig, J. D. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.2.165 · Cited by 59 · see citing works
Wägner, A. M., Pérez, A., Zapico, E., & Ordóñez‐Llanos, J. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2048 · Cited by 58 · see citing works
Stein, E. A., Sniderman, A. D., & Laskarzewski, P. M. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.006 · Cited by 58 · see citing works
Carrero, J. J., Fonollá, J., Marti, J. L., Jiménez, J., Bozá, J., & López‐Huertas, E. (2007) · Journal of Nutrition · doi:10.1093/jn/137.2.384 · Cited by 56 · see citing works
A Review of Lipid Management in Primary and Secondary Prevention
Dembowski, E., & Davidson, M. H. (2009) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e318192754e · Cited by 52 · see citing works
Sharma, R. K. (2009) · Vascular Health and Risk Management · doi:10.2147/vhrm.s5684 · Cited by 49 · see citing works
Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering
Pikuleva, I. A. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.11.1403 · Cited by 49 · see citing works
Molecular actions of hypocholesterolaemic compounds from edible mushrooms
Gil‐Ramírez, A., Morales, D., & Soler‐Rivas, C. (2017) · Food & Function · doi:10.1039/c7fo00835j · Cited by 48 · see citing works
IMPACT OF ANTIOXIDANTS FROM DRUMSTICK LEAVES ON THE LIPID PROFILE OF HYPERLIPIDEMICS
Nambiar, V. S., Guin, P., Parnami, S., & Daniel, M. (2010) · Cited by 48 · see citing works
Diabetes Nutrition and Complications Trial
Cruz, A. F., & Calle‐Pascual, A. L. (2004) · Diabetes Care · doi:10.2337/diacare.27.4.984 · Cited by 48 · see citing works
Present and future therapeutic strategies in non-alcoholic fatty liver disease
Calamita, G., & Portincasa, P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.9.1231 · Cited by 47 · see citing works
Grundy, S. M., Vega, G. L., Tomassini, J. E., & Tershakovec, A. M. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.04.018 · Cited by 47 · see citing works
Self-citationLi, N., Li, Q., Tian, X.-Q., Qian, H.-Y., & Yang, Y.-J. (2014) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-014-0077-0 · Cited by 45 · see citing works
Effect of leisure time physical activity on blood lipid levels: the ATTICA study
Panagiotakos, D. B., Pitsavos, C. E., Chrysohoou, C. A., Skoumas, J., Zeimbekis, A., Papaioannou, I., & Stefanadis, C. (2003) · Coronary Artery Disease · doi:10.1097/00019501-200312000-00003 · Cited by 45 · see citing works
Metabolic Syndrome: Therapeutic Considerations
Grundy, S. M. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-27661-0_3 · Cited by 44 · see citing works
Self-citationOkazaki, M., Usui, S., Fukui, A., Kubota, I., & Tomoike, H. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.070094 · Cited by 44 · see citing works
Prevention of Cardiovascular Ischemic Events
Genest, J. J., & Pedersen, T. R. (2003) · Circulation · doi:10.1161/01.cir.0000067881.26274.bd · Cited by 43 · see citing works
Khalil, H., Maksoud, A. I. A. E., Alian, A., El-Hamady, W. A., Daif, A., Awad, A. M., & Guirgis, A. A. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1635619 · Cited by 42 · see citing works
Liang, K., Tsai, I., Lee, W., Lee, I., Lee, W., Lin, S., Wan, C., Fu, C., Ting, C.-T., & Sheu, W. H. (2011) · Obesity · doi:10.1038/oby.2011.155 · Cited by 40 · see citing works
Atherogenic dyslipidemia and diabetes mellitus: what’s new in the management arena?
Kumar, A. (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s5686 · Cited by 40 · see citing works
Færgeman, O., Hill, L., Windler, E., Wiklund, O., Asmar, R., Duffield, E. L., & Sosef, F. (2008) · Cardiology · doi:10.1159/000127442 · Cited by 39 · see citing works
Sardu, C., Santamaria, M., Funaro, S., Sacra, C., Barbieri, M., Paolisso, P., Marfella, R., Paolisso, G., & Rizzo, M. R. (2017) · Medicine · doi:10.1097/md.0000000000006558 · Cited by 39 · see citing works
May subclinical arterial disease help to better detect and treat high-risk asymptomatic individuals?
Simon, A. C., & Levenson, J. A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000184407.20257.58 · Cited by 39 · see citing works
for the CASE-J Trial Group, Nakao, K., Hirata, M., Oba, K., Yasuno, S., Ueshima, K., Fujimoto, A., Ogihara, T., & Saruta, T. (2010) · Hypertension Research · doi:10.1038/hr.2010.38 · Cited by 37 · see citing works
Rallidis, L. S., Pitsavos, C. E., Panagiotakos, D. B., Sinos, L., Stefanadis, C., & Kremastinos, D. T. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.09.022 · Cited by 36 · see citing works
Significance of High Density Lipoprotein-Cholesterol in Cardiovascular Risk Prevention
Ascaso, J. F., ndez-Cruz, A. F., Santos, P. G. L., Hernández‐Mijares, A., Mangas, A., n, J. M., Pallardo, L. F., Pedro‐Botet, J., Pérez‐Jiménez, F., a, G. P., et al. (2004) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200404050-00003 · Cited by 36 · see citing works
Song, G., Tian, H., Qin, S., Sun, X., Yao, S., Zong, C., Luo, Y., Liu, J., Yu, Y., Sang, H., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.043 · Cited by 35 · see citing works
Kurniawan, A., Hsu, C.-Y., Rau, H.-H., Lin, L.-Y., & Chao, J. (2019) · Nutrix Journal · doi:10.1186/s12937-019-0452-4 · Cited by 30 · see citing works
Association of Simvastatin and Hyperlipidemia With Periodontal Status and Bone Metabolism Markers
Magán‐Fernández, A., Ramírez, L. P., Tomás, J., Marfil‐Álvarez, R., Rizzo, M., Bravo, M., & Mesa, F. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.130652 · Cited by 34 · see citing works
Efficacy and safety of mipomersen sodium (Kynamro)
Hovingh, K., Besseling, J., & Kastelein, J. J. P. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.793670 · Cited by 33 · see citing works
Carotid artery thickness in children and young adults with end stage renal disease
Poyrazoğlu, H. M., Düşünsel, R., Yıkılmaz, A., Narın, N., Anarat, R., Gündüz, Z., Çoşkun, A., Baykan, A., & Ozturk, A. B. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0268-2 · Cited by 33 · see citing works
Increased serum lipids are associated with higher CD4 lymphocyte count in HIV‐infected women
Floris-Moore, M., Howard, A., Lo, Y., Arnsten, J. H., Santoro, N. F., & Schoenbaum, E. E. (2006) · HIV Medicine · doi:10.1111/j.1468-1293.2006.00401.x · Cited by 32 · see citing works
Increased ApoB in Small Dense LDL Particles Predicts Premature Coronary Artery Disease
Brunzell, J. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000156537.78366.1d · Cited by 32 · see citing works
Blood stasis syndrome of coronary heart disease: A perspective of modern medicine
Gui, Y., & Wang, J. (2013) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-013-1332-3 · Cited by 31 · see citing works
Gohlke, H., Winter, M., Karoff, M., & Held, K. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000244581.30421.69 · Cited by 31 · see citing works
Single‐center retrospective study of long‐term use of low‐dose acitretin (Soriatane®) for psoriasis
Lee, E., & Koo, J. Y. M. (2004) · Journal of Dermatological Treatment · doi:10.1080/095466303100184473 · Cited by 31 · see citing works
Effect of different LDL‐apheresis methods on parameters involved in atherosclerosis
Hershcovici, T., Schechner, V., ORLIN, J. B., Harell, D., & Beigel, Y. (2004) · Journal of Clinical Apheresis · doi:10.1002/jca.20006 · Cited by 30 · see citing works
Hyperlipidemia aggravates renal disease in B6.ROP Os/+ mice
Mühlfeld, A., Spencer, M. W., Hudkins, K. L., Kirk, E. A., LeBoeuf, R. C., & Alpers, C. E. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00854.x · Cited by 30 · see citing works
Beebe, N., Magnanti, S., Katkowski, L., Benson, M. C., Xu, F., Delmonico, M. J., & Lofgren, I. E. (2013) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2012.0531 · Cited by 29 · see citing works
Dayspring, T. D., Qu, Y., & Keech, C. A. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.005 · Cited by 29 · see citing works
Therapeutic approaches to dyslipidemia in diabetes mellitus and metabolic syndrome
Cottrell, D. A., Marshall, B. J., & Falko, J. M. (2003) · Current Opinion in Cardiology · doi:10.1097/00001573-200307000-00010 · Cited by 29 · see citing works
Le, N., Tomassini, J. E., Tershakovec, A. M., Neff, D., & Wilson, P. W. F. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001675 · Cited by 28 · see citing works
Food prices and blood cholesterol
Rahkovsky, I. M., & Gregory, C. (2012) · Economics & Human Biology · doi:10.1016/j.ehb.2012.01.004 · Cited by 27 · see citing works
Prevention of heart failure in the elderly: when, where and how to begin?
Jugdutt, B. I. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9299-x · Cited by 26 · see citing works
Aryal, M., Poudel, A., Satyal, B., Gyawali, P., Pokheral, B., Raut, B., Adhikari, R., & Koju, R. (2012) · Kathmandu University Medical Journal · doi:10.3126/kumj.v8i4.6239 · Cited by 23 · see citing works
- Authors
- Grundy, S. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Grundy, Scott M.
- ORCID
- Grundy, Scott M.
- Venue
- Circulation
- Published
- 2002-11-12
- Volume
- 106
- Issue
- 20
- Pages
- 2526-2529
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2135020991
- Cited by
- 309
- References
- 25
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- low-density lipoprotein, non-HDL cholesterol, apolipoprotein B, lipid-lowering therapy, VLDL, intermediate density lipoprotein, high-density lipoprotein, triglyceride-rich lipoproteins, atherogenesis, coronary heart disease risk, stroke risk, Adult Treatment Panel III
- MeSH terms
- Hypolipidemic Agents, Apolipoproteins B, Cholesterol, Coronary Artery Disease, Coronary Disease, Humans, Lipoproteins, Cholesterol, HDL, Lipoproteins, LDL, Prognosis, Risk Factors, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review