Cited by 309Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins

Low-Density Lipoprotein, Non-High-Density Lipoprotein, and Apolipoprotein B as Targets of Lipid-Lowering Therapy

Grundy, Scott M.·2002·Circulation

Abstract

lthough low-density lipoprotein (LDL) is widely recognized as the major atherogenic lipoprotein and the primary target of lipid-lowering therapy, 1 other lipoprotein species nonetheless appear to be involved in atherogenesis.These include very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and highdensity lipoproteins (HDL).Both VLDL and IDL are triglyceride-rich lipoproteins (TGRLP).Thus, in the aftermath of unequivocal evidence that LDL lowering reduces risk for major coronary events and stroke, 2 the field of lipid study is turning more of its attention to the other lipoproteins that appear to be involved in atherosclerosis.The recent Adult Treatment Panel III (ATP III) report 1 of the National Cholesterol Education Program has summarized our current understanding of the relationship between other lipoprotein species and risk for coronary heart disease (CHD).

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Crossref · 10.1161/01.cir.0000038419.53000.d6

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Authors
Grundy, S. M.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Grundy, Scott M.
Venue
Circulation
Published
2002-11-12
Volume
106
Issue
20
Pages
2526-2529
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2135020991
Cited by
309
References
25
Citations by year
2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 20
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
low-density lipoprotein, non-HDL cholesterol, apolipoprotein B, lipid-lowering therapy, VLDL, intermediate density lipoprotein, high-density lipoprotein, triglyceride-rich lipoproteins, atherogenesis, coronary heart disease risk, stroke risk, Adult Treatment Panel III
MeSH terms
Hypolipidemic Agents, Apolipoproteins B, Cholesterol, Coronary Artery Disease, Coronary Disease, Humans, Lipoproteins, Cholesterol, HDL, Lipoproteins, LDL, Prognosis, Risk Factors, Drug Delivery Systems

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