The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
A short history of blebbing
Abstract
Summary: Blebs are protrusions of the cell membrane. They are the result of actomyosin contractions of the cortex, which cause either transient detachment of the cell membrane from the actin cortex or a rupture in the actin cortex. Then, cytosol streams out of the cell body and inflates the newly formed bleb. During expansion, which lasts ∼30 s, the bleb is devoid of actin and the surface area increases through further tearing of membrane from the cortex and convective flows of lipids in the plane of the membrane through the bleb neck. Once expansion slows, an actin cortex is reconstituted. First actin‐membrane linker proteins, such as ezrin, are recruited to the bleb, then actin, actin‐bundling proteins and finally myosin motor proteins. Retraction lasts ∼2 min and is powered by myosin motor proteins. Though it has been less studied than other actin‐based membrane protrusions such as lamellipodia or filopodia, blebbing is a common feature of cell physiology during cell movement, cytokinesis, cell spreading and apoptosis. This review will succinctly attempt to summarize what we know about the mechanisms involved in blebbing, when it appears in cell physiology and what open questions remain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tumour-cell invasion and migration: diversity and escape mechanisms
Friedl, P., & Wolf, K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1075 · Cited by 3,222
Geometry and Physics of Wrinkling
Cerda, E., & Mahadevan, L. (2003) · Physical Review Letters · doi:10.1103/physrevlett.90.074302 · Cited by 1,322
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
Coleman, M. L., Sahai, E. A., Yeo, M., Bosch, M., Dewar, A., & Olson, M. F. (2001) · Nature Cell Biology · doi:10.1038/35070009 · Cited by 1,311
ERM proteins and merlin: integrators at the cell cortex
Bretscher, A., Edwards, K., & Fehon, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm882 · Cited by 1,306
Sahai, E., & Marshall, C. J. (2003) · Nature Cell Biology · doi:10.1038/ncb1019 · Cited by 1,147
Molecular Basis of Mechanotransduction in Living Cells
Hamill, O. P., & Martinac, B. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.685 · Cited by 1,134
Filamins as integrators of cell mechanics and signalling
Stossel, T. P., Condeelis, J., Cooley, L., Hartwig, J. H., Noegel, A., Schleicher, M., & Shapiro, S. S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052082 · Cited by 1,020
Hartwig, J. H., Thelen, M., Resen, A., Janmey, P. A., Nairn, A. C., & Aderem, A. (1992) · Nature · doi:10.1038/356618a0 · Cited by 730
Non-equilibration of hydrostatic pressure in blebbing cells
Charras, G. T., Yarrow, J. C., Horton, M. A., Mahadevan, L., & Mitchison, T. J. (2005) · Nature · doi:10.1038/nature03550 · Cited by 654
Self-citationReassembly of contractile actin cortex in cell blebs
Charras, G. T., Hu, C.-K., Coughlin, M., & Mitchison, T. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602085 · Cited by 619
Self-citation
Cited by
Cox, C. D., Bae, C., Ziegler, L., Hartley, S., Nikolova-Krstevski, V., Rohde, P. R., Ng, C.-A., Sachs, F., Gottlieb, P. A., & Martinac, B. (2016) · Nature Communications · doi:10.1038/ncomms10366 · Cited by 528
Cardiac troponins: from myocardial infarction to chronic disease
Park, K. C., Gaze, D. C., Collinson, P. O., & Marber, M. S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx183 · Cited by 510
The Lateral Organization and Mobility of Plasma Membrane Components
Jacobson, K., Liu, P., & Lagerholm, B. C. (2019) · Cell · doi:10.1016/j.cell.2019.04.018 · Cited by 268
P2X7 Interactions and Signaling – Making Head or Tail of It
Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217
Darmellah, A., Rayah, A., Auger, R., Cuif, M.-H., Prigent, M., Arpin, M., Alcover, A., Delarasse, C., & Kanellopoulos, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400010 · Cited by 38
Metadata
- Authors
- CHARRAS, G. T.
- Venue
- Journal of Microscopy
- Publisher
- Wiley
- Published
- 2008-08-28
- Volume
- 231
- Issue
- 3
- Pages
- 466-478
- ISSN
- 0022-2720 (ISSN-L)
- 1365-2818
- OpenAlex
- W2043879728
- Cited by
- 320
- References
- 59
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A short history of blebbing. https://app.cochat.ai/papers/10.1111/j.1365-2818.2008.02059.x
- The paper
- CHARRAS, G. T. (2008). A short history of blebbing. Journal of Microscopy. https://doi.org/10.1111/j.1365-2818.2008.02059.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
