Ezrin/Radixin/Moesin Are Required for the Purinergic P2X7 Receptor (P2X7R)-dependent Processing of the Amyloid Precursor Protein
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The amyloid precursor protein (APP) can be cleaved by α-secretases in neural cells to produce the soluble APP ectodomain (sAPPα), which is neuroprotective. We have shown previously that activation of the purinergic P2X7 receptor (P2X7R) triggers sAPPα shedding from neural cells. Here, we demonstrate that the activation of ezrin, radixin, and moesin (ERM) proteins is required for the P2X7R-dependent proteolytic processing of APP leading to sAPPα release. Indeed, the down-regulation of ERM by siRNA blocked the P2X7R-dependent shedding of sAPPα. We also show that P2X7R stimulation triggered the phosphorylation of ERM. Thus, ezrin translocates to the plasma membrane to interact with P2X7R. Using specific pharmacological inhibitors, we established the order in which several enzymes trigger the P2X7R-dependent release of sAPPα. Thus, a Rho kinase and the MAPK modules ERK1/2 and JNK act upstream of ERM, whereas a PI3K activity is triggered downstream. For the first time, this work identifies ERM as major partners in the regulated non-amyloidogenic processing of APP.
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Activation of MSN in association with ezrin and radixin has been implicated in the neuroprotective non-amyloidogenic processing of APP.
“Its activation in association with proteins ezrin and radixin has been implicated in the neuroprotective non-amyloidogenic processing of APP [123, 124].”
From Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau (2021) · cites this paper as [123]
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Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?
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Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases
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Tumor Suppressor NF2 Blocks Cellular Migration by Inhibiting Ectodomain Cleavage of CD44
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Purinergic receptors in cognitive disturbances
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P2X7-dependent immune pathways in retinal diseases
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Self-citationA proteomic atlas of kidney amyloidosis provides insights into disease pathogenesis
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Le récepteur P2X7, une nouvelle cible thérapeutique dans la maladie d’Alzheimer
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Self-citationUnlocking the P2X7 Pathway: A Therapeutic Target in Alzheimer’s Disease
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Tau and amyloid-β imaging with proteomics and genomics
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Novel Therapeutic Targets for Treating Alzheimer’s Disease
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Roles of Purinergic Receptors in Alzheimer’s Disease
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The Use of Localized Proteomics to Understand the Pathogenesis of Alzheimer's Disease
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- Authors
- Darmellah, A., Rayah, A., Auger, R., Cuif, M.-H., Prigent, M., Arpin, M., Alcover, A., Delarasse, C., & Kanellopoulos, J. M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université Paris-Sud (FR)
- Corresponding author
- Delarasse, Cécile
- Kanellopoulos, Jean M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 287
- Issue
- 41
- Pages
- 34583-34595
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3464564
- OpenAlex
- W1971870999
- Cited by
- 38
- References
- 75
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-07-BLAN-0089)
- Association France Alzheimer
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- amyloid precursor protein, P2X7 receptor, ezrin, radixin, moesin, ERM proteins, alpha-secretase, Rho kinase, ERK1/2, JNK, phosphatidylinositol 3-kinase, receptor translocation, purinergic signaling
- MeSH terms
- Ezrin, Animals, Cytoskeletal Proteins, Humans, Membrane Proteins, Microfilament Proteins, Amyloid beta-Protein Precursor, Phosphatidylinositol 3-Kinases, Mitogen-Activated Protein Kinase 1, Cell Line, Tumor, Mitogen-Activated Protein Kinase 3, Mice, rho-Associated Kinases, HEK293 Cells, Receptors, Purinergic P2X7, Proteolysis
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