Cited by 298Stress Responses and CortisolNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation

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Brunton, P. J., Russell, J. A., Douglas, A. J.·2008·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2008.01735.x

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Abstract

Over the past 40 years, it has been recognised that the maternal hypothalamic‐pituitary‐adrenal (HPA) axis undergoes adaptations through pregnancy and lactation that might contribute to avoidance of adverse effects of stress on the mother and offspring. The extent of the global adaptations in the HPA axis has been revealed and the underlying mechanisms investigated within the last 20 years. Both basal, including the circadian rhythm, and stress‐induced adrenocorticotrophic hormone and glucocorticoid secretory patterns are altered. Throughout most of pregnancy, and in lactation, these changes predominantly reflect reduced drive by the corticotropin‐releasing factor (CRF) neurones in the parvocellular paraventricular nucleus (pPVN). An accompanying profound attenuation of HPA axis responses to a wide variety of psychological and physical stressors emerges after mid‐pregnancy and persists until the end of lactation. Central to this suppression of stress responsiveness is reduced activation of the pPVN CRF neurones. This is consequent on the reduced effectiveness of the stimulation of brainstem afferents to these CRF neurones (for physical stressors) and of altered processing by limbic structures (for emotional stressors). The mechanism of reduced CRF neurone responses to physical stressors in pregnancy is the suppression of noradrenaline release in the PVN by an up‐regulated endogenous opioid mechanism, which is induced by neuroactive steroid produced from progesterone. By contrast, in lactation suckling the young provides a neural stimulus that dampens the HPA axis circadian rhythm and reduces stress responses. Reduced noradrenergic input activity is involved in reduced stress responses in lactation, although central prolactin action also appears important. Such adaptations limit the adverse effects of excess glucocorticoid exposure on the foetus(es) and facilitate appropriate metabolic and immune responses.

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Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322
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Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Prenatal stress, glucocorticoids and the programming of the brain
Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928
A placental clock controlling the length of human pregnancy
McLean, M. P., Bisits, A. M., Davies, J., Woods, R., Lowry, P., & Smith, R. (1995) · Nature Medicine · doi:10.1038/nm0595-460 · Cited by 907
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655
Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum
MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621
Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439
Self-citation

Show all 155 references

Research works printed but not linked: 6

Brunton PJ, 2000, Central mechanisms underlying reduced ACTH stress responses in pregnant rats: attenuated acute gene activation in the parvocellular paraventricular nucleus (pPVN), Eur J Neurosci, 12, 184
10.1210/en.140.6.2843 · DOI
10.1210/jc.80.10.2954 · DOI
10.1210/en.142.5.2032 · DOI
10.1210/endo.138.7.5255 · DOI · Paper page
10.1210/me.6.1.35 · DOI

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Authors: Brunton, P. J., Russell, J. A., & Douglas, A. J.
Affiliations: University of Edinburgh (GB)
Corresponding author: Russell, J. A.
ORCID: Brunton, P. J.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2008-06
Volume: 20
Issue: 6
Pages: 764-776
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2008.01735.x
OpenAlex: W2125486541
Cited by: 298
References: 155
Citations by year: 2026: 11 · 2025: 11 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 18 · 2020: 20 · 2019: 21 · 2018: 6 · 2017: 13 · 2016: 21 · 2015: 17 · 2014: 25 · 2013: 13 · 2012: 12
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 39 d)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Society for Endocrinology
European Commission
Directorate for Biological Sciences
Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: pregnancy, lactation, corticotropin-releasing factor, paraventricular nucleus, stress responsiveness, glucocorticoids, ACTH, circadian rhythm, norepinephrine, endogenous opioids, neurosteroids, progesterone, prolactin, suckling
MeSH terms: Analgesics, Opioid, Animals, Animals, Suckling, Arginine Vasopressin, Circadian Rhythm, Corticotropin-Releasing Hormone, Female, Humans, Hypothalamo-Hypophyseal System, Lactation, Pituitary-Adrenal System, Pregnancy, Prolactin, Stress, Psychological

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Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation

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