Glucocorticoids, metabolism and metabolic diseases

Vegiopoulos, Alexandros; Herzig, Stephan

doi:10.1016/j.mce.2007.05.015

Cited by 535Estrogen and related hormone effectsAdipokines, Inflammation, and Metabolic DiseasesAdrenal Hormones and Disorders

Glucocorticoids, metabolism and metabolic diseases

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Vegiopoulos, Alexandros, Herzig, Stephan·2007·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2007.05.015

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Abstract

Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical components of the delicate hormonal control system that determines energy homeostasis in mammals. Whereas physiological levels of GCs are required for proper metabolic control, excessive GC action has been tied to a variety of pandemic metabolic diseases, such as type II diabetes and obesity. Highlighted by its importance for human health, the investigation of molecular mechanisms of GC/GR action has become a major focus in biomedical research. In particular, the understanding of tissue-specific functions of the GC-GR pathway has been proven to be of substantial value for the identification of novel therapeutic options in the treatment of severe metabolic disorders. Therefore, this review focuses on the role of the GC-GR axis for metabolic homeostasis and dysregulation, emphasizing tissue-specific functions of GCs in the control of energy metabolism.

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GCs were shown to induce phosphoenolpyruvate carboxykinase, the rate-controlling enzyme in hepatic glucose production.
“GCs were shown to induce phosphoenolpyruvate carboxykinase, the rate-controlling enzyme in hepatic glucose production [41].”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [41]

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Authors: Vegiopoulos, A., & Herzig, S.
Affiliations: German Cancer Research Center (DE)
Corresponding author: Herzig, Stephan
ORCID: Vegiopoulos, Alexandros
Herzig, Stephan
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2007-09
Volume: 275
Issue: 1-2
Pages: 43-61
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2007.05.015
OpenAlex: W2074706971
Cited by: 535
References: 290
Citations by year: 2026: 15 · 2025: 25 · 2024: 32 · 2023: 38 · 2022: 33 · 2021: 37 · 2020: 32 · 2019: 29 · 2018: 29 · 2017: 31 · 2016: 27 · 2015: 30 · 2014: 28 · 2013: 34 · 2012: 33
FWCI: 1.85
Type: journal article
Language: en
Open access: green
hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, glucocorticoid receptor, energy homeostasis, metabolic disorders, type 2 diabetes, obesity, metabolic dysfunction, adrenocortical extract, therapeutic target
MeSH terms: Animals, Energy Metabolism, Glucocorticoids, Homeostasis, Humans, Metabolic Diseases, Receptors, Glucocorticoid

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Glucocorticoids, metabolism and metabolic diseases

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