The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Virologic factors associated with failure to passive–active immunoprophylaxis in infants born to HBsAg‐positive mothers
Abstract
Summary. In infants born to hepatitis B surface antigen (HBsAg)–positive mothers, failure after passive–active immunization still occurs. The role of maternal hepatitis B DNA level and other risk factors in this setting remains unclear. This study retrospectively evaluated virologic and other risk factors associated with immunoprophylaxis failure in infants born to HBsAg‐positive mothers. Between January 2007 and March 2010, we reviewed the clinical and virologic tests in 869 mother–infant pairs. All infants received the identical passive–active immunization schedule after birth. The failure infants (HBsAg positive at 7–12 months of age) were compared to infants who were HBsAg negative when tested during this time period. Among 869 infants, 27 (3.1%) infants were immunoprophylaxis failures and the other 842 (96.9%) infants remained HBsAg negative. When mothers’ pre‐delivery HBV DNA levels were stratified to <6, 6–6.99, 7–7.99 and ≥8 log 10 copies/mL, the corresponding rates of immunoprophylaxis failure were 0%, 3.2% (3/95), 6.7% (19/282) and 7.6% (5/66), respectively (P < 0.001 for the trend). All failure infants were born to hepatitis B e antigen (HBeAg)–positive mothers. Multivariate logistic regression analysis identified maternal HBV DNA levels [odds ratio (OR) = 1.88, 95% confidence interval (CI): 1.07–3.30] and detectable HBV DNA in the cord blood (OR = 39.67, 95% CI: 14.22–110.64) as independent risk factors for immunoprophylaxis failure. All failure infants were born to HBeAg‐positive mothers with HBV DNA levels ≥6 log 10 copies/mL. The presence of HBV DNA in cord blood predicted failure to passive–active immunization.
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Tenofovir to Prevent Hepatitis B Transmission in Mothers with High Viral Load
Pan, C. Q., Duan, Z., Dai, E., Zhang, S., Han, G., Wang, Y., Zhang, H., Zou, H., Zhu, B., Zhao, W., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1508660 · Cited by 573
Self-citationHepatitis B Virus: Advances in Prevention, Diagnosis, and Therapy
Nguyen, M. H., Wong, G., Gane, E., Kao, J.-H., & Dusheiko, G. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-19 · Cited by 554
Hepatitis B in sub-Saharan Africa: strategies to achieve the 2030 elimination targets
Spearman, C. W., Afihene, M., Ally, R., Apica, B., Awuku, Y., Cunha, L., Dusheiko, G., Gogela, N., Kassianides, C., Kew, M., et al. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(17)30295-9 · Cited by 361
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Metadata
- Authors
- Zou, H., Chen, Y., Duan, Z., Zhang, H., & Pan, C.
- Venue
- Journal of Viral Hepatitis
- Publisher
- Wiley
- Published
- 2011-08
- Volume
- 19
- Issue
- 2
- Pages
- e18-25
- ISSN
- 1352-0504 (ISSN-L)
- 1365-2893
- OpenAlex
- W1599401828
- Cited by
- 366
- References
- 22
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zou, H., Chen, Y., Duan, Z., Zhang, H., & Pan, C. (2012). Virologic factors associated with failure to passive–active immunoprophylaxis in infants born to HBsAg‐positive mothers. Journal of Viral Hepatitis. https://doi.org/10.1111/j.1365-2893.2011.01492.x
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