The DOI matches its Crossref record.
The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells
Abstract
Summary: The influence of the two surface structures of Neisseria meningitidis, capsule and pili, in bacterial interactions with human endothelial cells was investigated. Increased association correlated with the presence of pili on bacteria while capsule type had no apparent effect. Strains expressing both Class I and Class II pili associated with endothelial cells in significantly larger numbers compared with the non‐piliated variants of the same strains (>10×). Variants of Neisseria gonorrhoeae strain P9 expressing antigenically distinct pili also associated with endothelial cells in larger numbers (>30×) compared with the non‐piliated variant. Electron microscopic studies confirmed these data and showed that gonococci were internalized more frequently compared with meningococci. One consequence of increased association was an increase in the cytopathic effect of bacteria on the target cells.
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Citations
Cited by
Albers, S.-V., & Meyer, B. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2576 · Cited by 542
Dando, S. J., Mackay-Sim, A., Norton, R., Currie, B. J., St. John, J. A., Ekberg, J. A. K., Batzloff, M., Ulett, G. C., & Beacham, I. R. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00118-13 · Cited by 428
Virji, M., Makepeace, K., Ferguson, D. J. P., Achtman, M., & Moxon, E. R. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb00922.x · Cited by 263
Self-citationShared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections.
Deitsch, K. W., Moxon, E. R., & Wellems, T. E. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.3.281-293.1997 · Cited by 255
Self-citationInteractions of Neisseria meningitidis with cells of the human meninges
Hardy, S. J., Christodoulides, M., Weller, R. O., & Heckels, J. E. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01923.x · Cited by 78
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Metadata
- Authors
- Virji, M., Kayhty, H., Ferguson, D. J. P., Alexandrescu, C., Heckels, J. E., & Moxon, E. R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1991-08
- Volume
- 5
- Issue
- 8
- Pages
- 1831-1841
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2154059829
- Cited by
- 207
- References
- 0
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells. https://app.cochat.ai/papers/10.1111/j.1365-2958.1991.tb00807.x
- The paper
- Virji, M., Kayhty, H., Ferguson, D. J. P., Alexandrescu, C., Heckels, J. E., & Moxon, E. R. (1991). The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1991.tb00807.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
