The DOI matches its Crossref record.
Genetics of resistance to third‐generation cephalosporins in clinical isolates of Streptococcus pneumoniae
Abstract
Summary: Resistance to third‐generation cephalosporins in a clinical isolate of Streptococcus pneumoniae was shown to be due to the production of altered forms of penicillin‐binding proteins (PBPs) 2X and 1A. The cloned PBP2X gene from the resistant strain was able to transform a susceptible strain to an intermediate level of resistance. The resulting transformant could be transformed to the full level of resistance of the clinical isolate using the cloned PBP1A gene from the latter strain. Chromosomal DNA from the resistant strain (and from other resistant strains) could readily transform a susceptible strain to the full level of resistance to third‐generation cephalosporins (>250‐fold for cefotaxime; >100‐fold for ceftriaxone) in a single step (transformation frequency of about 10‐5). The resistant transformants obtained with chromosomal DNA were shown by gene fingerprinting to have gained both the PBP1A and PBP2X genes from the DNA donor.
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Cited by
Pallares, R., Liñares, J., Vadillo, M., Cabellos, C., Manresa, F., Viladrich, P. F., Martin, R., & Gudiol, F. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508243330802 · Cited by 773
Doern, G. V., Brueggemann, A., Holley, H. P., & Rauch, A. M. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.5.1208 · Cited by 482
Molecular Mechanisms of β-Lactam Resistance in Streptococcus Pneumoniae
Hakenbeck, R., Brückner, R., Denapaite, D., & Maurer, P. (2012) · Future Microbiology · doi:10.2217/fmb.12.2 · Cited by 183
Self-citationLi, L., Wan, Y., Wang, Y., Tao, Y., Long, X., Liu, E., & Deng, Y. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04066-5 · Cited by 2
Metadata
- Authors
- Muñoz, R., Dowson, C. G., Daniels, M., Coffey, T. J., Martin, C., Hakenbeck, R., & Spratt, B. G.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1992-09
- Volume
- 6
- Issue
- 17
- Pages
- 2461-2465
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2038865476
- Cited by
- 193
- References
- 0
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Muñoz, R., Dowson, C. G., Daniels, M., Coffey, T. J., Martin, C., Hakenbeck, R., & Spratt, B. G. (1992). Genetics of resistance to third‐generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1992.tb01422.x
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