The DOI matches its Crossref record.
Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis
Abstract
Summary: Whereas capsulate strains of Neisseria meningitidis are dependent on pili for adhesion to human endothelial and epithelial cells, strains which lacked assembled pili and were partially capsule‐deficient adhered to and invaded human endothelial and epithelial cells if they expressed the Opc protein. Bacteria expressing low or undetectable levels of Opc protein failed to adhere to or invade eukaryotic cells. In addition, the presence of OpaA c751 protein on the surface of bacteria did not increase bacterial interactions with host cells. Association of Opc‐expressing bacteria was inhibited by antibodies against Opc. Invasion was dependent on the host‐cell cytoskeletal activity and was inhibited by cytochalasin D. In some cells, infected at the apical surface, bacteria emerging from basal surface were detected by electron microscopy. Opc is found in diverse meningococci and may represent a common virulence factor, which facilitates adherence and invasion by these bacteria.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Neisseria meningitidis: Biology, Microbiology, and Epidemiology
Rouphael, N. G., & Stephens, D. S. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-346-2_1 · Cited by 425
Virji, M., Makepeace, K., Ferguson, D. J. P., Achtman, M., & Moxon, E. R. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb00922.x · Cited by 263
Self-citationShared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections.
Deitsch, K. W., Moxon, E. R., & Wellems, T. E. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.3.281-293.1997 · Cited by 255
Self-citationInteractions of Neisseria meningitidis with cells of the human meninges
Hardy, S. J., Christodoulides, M., Weller, R. O., & Heckels, J. E. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01923.x · Cited by 78
Metadata
- Authors
- Virji, M., Makepeace, K., Ferguson, D. J. P., Achtman, M., Sarkari, J., & Moxon, E. R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1992-10
- Volume
- 6
- Issue
- 19
- Pages
- 2785-2795
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2168114352
- Cited by
- 168
- References
- 0
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis. https://app.cochat.ai/papers/10.1111/j.1365-2958.1992.tb01458.x
- The paper
- Virji, M., Makepeace, K., Ferguson, D. J. P., Achtman, M., Sarkari, J., & Moxon, E. R. (1992). Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1992.tb01458.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
