The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Role of KatG catalase‐peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst
Open accessAbstract
Summary: Reactive nitrogen species (RNS) play an essential role in host defence against Mycobacterium tuberculosis (MTB) in the mouse model of tuberculosis (TB), as evidenced by the increased susceptibility of mice deficient in the inducible isoform of nitric oxide synthase (NOS2). In contrast, the role of reactive oxygen species (ROS) in protection against MTB is less clear, and mice defective in the ROS‐generating phagocyte NADPH oxidase (Phox) are relatively resistant. This suggests that MTB might possess efficient mechanisms to evade or counter the phagocyte oxidative burst, effectively masking the impact of this host defence mechanism. In order to assess the role of ROS detoxification pathways in MTB virulence, we generated a katG null mutant of MTB, deficient in the KatG catalase‐peroxidase‐peroxynitritase, and evaluated the mutant's ability to replicate and persist in macrophages and mice. Although markedly attenuated in wild‐type C57Bl/6 mice and NOS2–/– mice, the Δ katG MTB strain was indistinguishable from wild‐type MTB in its ability to replicate and persist in gp91 Phox–/– mice lacking the gp91 subunit of NADPH oxidase. Similar observations were made with murine bone marrow macrophages infected ex vivo: growth of the Δ katG MTB strain was impaired in macrophages from C57Bl/6 and NOS2–/– mice, but indistinguishable from wild‐type MTB in gp91 Phox–/– macrophages. These results indicate that the major role of KatG in MTB pathogenesis is to catabolize the peroxides generated by the phagocyte NADPH oxidase; in the absence of this host antimicrobial mechanism, KatG is apparently dispensable.
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Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962
Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
McKinney, J. D., zu Bentrup, K. H., Muñoz-Elías, E. J., Miczak, A., Chen, B., Chan, W.-T., Swenson, D., Sacchettini, J. C., Jacobs, W. R., & Russell, D. G. (2000) · Nature · doi:10.1038/35021074 · Cited by 1,360
Self-citationIdentification of nitric oxide synthase as a protective locus against tuberculosis
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., & Nathan, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5243 · Cited by 1,180
Self-citationChan, J., Xing, Y., Magliozzo, R. S., & Bloom, B. R. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.4.1111 · Cited by 1,062
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991
Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease
Segal, B. H., Leto, T. L., Gallin, J. I., Malech, H. L., & Holland, S. M. (2000) · Medicine · doi:10.1097/00005792-200005000-00004 · Cited by 883
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685 · cited 2×
“…no direct evidence in support of this model in MTB, it has been shown that the intracellular trafficking and maturation of mycobacterium-containing phagosomes are dramatically altered by cytokine activation of infected macrophages (Schaible et al., 1998; Via et al., 1998; MacMicking et al., 2003).”
BackgroundSelf-citationThe damage-response framework of microbial pathogenesis
Casadevall, A., & Pirofski, L.-A. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro732 · Cited by 658
Cited by
Griffin, J. E., Gawronski, J. D., DeJesus, M. A., Ioerger, T. R., Akerley, B. J., & Sassetti, C. M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002251 · Cited by 1,048
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947
Mycobacterium tuberculosis: success through dormancy
Gengenbacher, M., & Kaufmann, S. H. E. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00331.x · Cited by 696
Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013) · Virulence · doi:10.4161/viru.22329 · Cited by 622
Immune evasion and provocation by Mycobacterium tuberculosis
Chandra, P., Grigsby, S. J., & Philips, J. A. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00763-4 · Cited by 614
Metadata
- Authors
- Ng, V. H., Cox, J. S., Sousa, A. O., MacMicking, J. D., & McKinney, J. D.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2004-04-30
- Volume
- 52
- Issue
- 5
- Pages
- 1291-1302
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2103512536
- Cited by
- 342
- References
- 44
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ng, V. H., Cox, J. S., Sousa, A. O., MacMicking, J. D., & McKinney, J. D. (2004). Role of KatG catalase‐peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2004.04078.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
