The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Involvement of a novel transcriptional activator and small RNA in post‐transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system
Open accessAbstract
Summary: RyaA is a small non‐coding RNA in Escherichia coli that was identified by its ability to bind tightly to the RNA chaperone Hfq. This study reports the role of RyaA in mediating the cellular response to glucose‐specific phosphoenolypyruvate phosphotransferase system (PTS)‐dependent phosphosugar stress. Aiba and co‐workers have shown that a block in the metabolism of glucose 6‐phosphate causes transient growth inhibition and post‐transcriptional regulation of ptsG , encoding the glucose‐specific PTS transporter. We found that RyaA synthesis was induced by a non‐metabolizable glucose phosphate analogue and was necessary for relief of the toxicity of glucose phosphate stress. Expression of RyaA was sufficient to cause a rapid loss of ptsG mRNA, probably reflecting degradation of the message mediated by RyaA: ptsG pairing. The ryaA gene was renamed sgrS , for s u g a r transport‐related s RNA. Expression of sgrS is regulated by a novel transcriptional activator, SgrR (formerly YabN), which has a putative DNA‐binding domain and a solute‐binding domain similar to those found in certain transport proteins. Our results suggest that under conditions of glucose phosphate accumulation, SgrR activates SgrS synthesis, causing degradation of ptsG mRNA. Decreased ptsG mRNA results in decreased production of glucose transport machinery, thus limiting further accumulation of glucose phosphate.
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Cites
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Cited by
Morita, T., Maki, K., & Aiba, H. (2005) · Genes & Development · doi:10.1101/gad.1330405 · Cited by 458
Quantitative Characteristics of Gene Regulation by Small RNA
Levine, E., Zhang, Z., Kuhlman, T., & Hwa, T. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050229 · Cited by 384
AN ABUNDANCE OF RNA REGULATORS
Storz, G., Altuvia, S., & Wassarman, K. M. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133136 · Cited by 371
Small Proteins Can No Longer Be Ignored
Storz, G., Wolf, Y. I., & Ramamurthi, K. S. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-070611-102400 · Cited by 359
Jiang, L., Li, S., Hu, Y., Xu, Q., & Huang, H. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.23346 · Cited by 36
Metadata
- Authors
- Vanderpool, C. K., & Gottesman, S.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2004-10-08
- Volume
- 54
- Issue
- 4
- Pages
- 1076-1089
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2148277388
- Cited by
- 355
- References
- 40
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vanderpool, C. K., & Gottesman, S. (2004). Involvement of a novel transcriptional activator and small RNA in post‐transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2004.04348.x
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