The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mucin– Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistance
Open accessAbstract
Summary: Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in people suffering from cystic fibrosis (CF). In CF airways, P. aeruginosa forms surface‐associated communities called biofilms. Compared with free‐swimming cultures, biofilms resist clearance by the host immune system and display increased resistance to antimicrobial agents. In this study we developed a technique to coat surfaces with molecules that are abundant in CF airways in order to investigate their impact on P. aeruginosa biofilm development. We found that P. aeruginosa biofilm development proceeds differently on surfaces coated with the glycoprotein mucin compared with biofilm development on glass and surfaces coated with actin or DNA. Biofilms formed on mucin‐coated surfaces developed large cellular aggregates and had increased tolerance to the antibiotic tobramycin compared with biofilms grown on glass. Analysis of selected mutant backgrounds in conjunction with time‐lapse microscopy revealed that surface‐associated motility was blocked on the mucin surface. Furthermore, our data suggest that a specific adhesin–mucin interaction immobilizes the bacterium on the surface. Together, these experiments suggest that mucin, which may serve as an attachment surface in CF airways, impacts P. aeruginosa biofilm development and function.
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“Neutrophil extracellular traps (NETs) can surround P. aeruginosa communities in dense DNA-rich barriers, while airway mucins reshape the architecture of the biofilm.”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [44]
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“Depending on the local environment, mucins can stabilize tolerant aggregates or instead promote dispersal [43,44,45].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [44]
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01062.x · Cited by 2,697
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Self-citationOral Microbial Communities: Biofilms, Interactions, and Genetic Systems
Kolenbrander, P. E. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.413 · Cited by 894
Stoodley, P., Jacobsen, A., Dunsmore, B. C., Purevdorj, B., Wilson, S., Lappin-Scott, H. M., & Costerton, J. W. (2001) · Water Science and Technology · doi:10.2166/wst.2001.0353 · Cited by 73
Cited by
Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials
Sambhy, V., MacBride, M. M., Peterson, B. R., & Sen, A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061442z · Cited by 748
Shrout, J. D., Chopp, D. L., Just, C. L., Hentzer, M., Givskov, M., & Parsek, M. R. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05421.x · Cited by 573
Self-citationTseng, B. S., Zhang, W., Harrison, J. J., Quach, T. P., Song, J. L., Penterman, J., Singh, P. K., Chopp, D. L., Packman, A. I., & Parsek, M. R. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12155 · Cited by 466
Self-citationElbehiry, A., Marzouk, E., Edrees, H. M., Ibrahem, M., Alzahrani, S., Anagreyyah, S., Abualola, H., Alghamdi, A., Alzahrani, A., Jaber, M., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14010109 · Cited by 34
Metadata
- Authors
- Landry, R. M., An, D., Hupp, J. T., Singh, P. K., & Parsek, M. R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2005-11-14
- Volume
- 59
- Issue
- 1
- Pages
- 142-151
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2159866367
- Cited by
- 201
- References
- 5
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Landry, R. M., An, D., Hupp, J. T., Singh, P. K., & Parsek, M. R. (2006). Mucin– Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistance. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2005.04941.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
