The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Regulation of fatty acid metabolism in bacteria
Open accessAbstract
Summary: In Escherichia coli, the main player in transcription regulation of fatty acid metabolism is the FadR protein, which is involved in negative regulation of fatty acid degradation and in positive and negative regulation of the cellular processes related to it, as well as in positive regulation of the biosynthesis of unsaturated fatty acids in a concerted manner with negative regulation of FabR. On the other hand, Bacillus subtilis possesses two global transcriptional regulators, FadR (YsiA) and FapR. B. subtilis FadR represses fatty acid degradation, whereas FapR represses almost all the processes in the biosynthesis of saturated fatty acids and phospholipids. Furthermore, Streptococcus pneumoniae FabT represses the genes of fatty acid biosynthesis that are clustered in its genome. Long‐chain acyl‐CoAs appear to be metabolic signals for fatty acid degradation by bacteria in general, and antagonize the FadR protein from either E. coli or B. subtilis. However, malonyl‐CoA is a metabolic signal for fatty acid and phospholipid biosynthesis by Gram‐positive low‐GC bacteria, and it antagonizes FapR. These would be the primary aspects for understanding the elaborate and complex regulation of fatty acid metabolism in bacteria to maintain membrane lipid homeostasis.
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Cites
Escherichia coli and Salmonella typhimurium: Cellular and molecular biology
Lejeune, P. (1988) · Biochimie · doi:10.1016/0300-9084(88)90119-8 · Cited by 4,072
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Self-citationThe KEGG databases at GenomeNet
Kanehisa, M. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.42 · Cited by 1,504
Cannibalism by sporulating bacteria.
González-Pastor, J. E., Hobbs, E. C., & Losick, R. (2003) · Science · doi:10.1126/science.1086462 · Cited by 579
Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery
Campbell, J. W., & Cronan, J. E. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.305 · Cited by 479
Multi-subunit acetyl-CoA carboxylases
Cronan, J. E., & Waldrop, G. L. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00007-3 · Cited by 468
Fatty acids of the genus Bacillus: an example of branched-chain preference
Kaneda, T. (1977) · Bacteriological Reviews · doi:10.1128/br.41.2.391-418.1977 · Cited by 442
Aguilar, P. S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1681 · Cited by 416
Overath, P., Pauli, G., & Schairer, H. U. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb19644.x · Cited by 353
Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
Rock, C. O., & Cronan, J. E. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00056-2 · Cited by 332
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Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering
Quintana, N., Van der Kooy, F., Van de Rhee, M. D., Voshol, G. P., & Verpoorte, R. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3394-0 · Cited by 338
New microbial fuels: a biotech perspective
Rude, M. A., & Schirmer, A. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.04.004 · Cited by 337
Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids
Beller, H. R., Lee, T. S., & Katz, L. (2015) · Natural Product Reports · doi:10.1039/c5np00068h · Cited by 153
Biosynthesis of Lipids and Hydrocarbons in Algae
Baba, M., & Shiraiw, Y. (2013) · Photosynthesis · doi:10.5772/56413 · Cited by 26
Tödter, D., Gunka, K., & Stülke, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00883 · Cited by 22
Metadata
- Authors
- Fujita, Y., Matsuoka, H., & Hirooka, K.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2007-09-17
- Volume
- 66
- Issue
- 4
- Pages
- 829-839
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2131191824
- Cited by
- 469
- References
- 65
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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