The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Role of staphylococcal wall teichoic acid in targeting the major autolysin Atl
Open accessAbstract
Summary: Staphylococcal cell separation depends largely on the bifunctional autolysin Atl that is processed to amidase‐R 1,2 and R 3 ‐glucosaminidase. These murein hydrolases are targeted via repeat domains (R) to the septal region of the cell surface, thereby allowing localized peptidoglycan hydrolysis and separation of the dividing cells. Here we show that targeting of the amidase repeats is based on an exclusion strategy mediated by wall teichoic acid (WTA). In Staphylococcus aureus wild‐type, externally applied repeats (R 1,2 ) or endogenously expressed amidase were localized exclusively at the cross‐wall region, while in Δ tag O mutant that lacks WTA binding was evenly distributed on the cell surface, which explains the increased fragility and autolysis susceptibility of the mutant. WTA prevented binding of Atl to the old cell wall but not to the cross‐wall region suggesting a lower WTA content. In binding studies with ConcanavalinA‐fluorescein (ConA‐FITC) conjugate that binds preferentially to teichoic acids, ConA‐FITC was bound throughout the cell surface with the exception of the cross wall. ConA binding suggest that either content or polymerization of WTA gradually increases with distance from the cross‐wall. By preventing binding of Atl, WTA directs Atl to the cross‐wall to perform the last step of cell division, namely separation of the daughter cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage
Kreiswirth, B. N., Löfdahl, S., Betley, M. J., O'Reilly, M., Schlievert, P. M., Bergdoll, M. S., & Novick, R. P. (1983) · Nature · doi:10.1038/305709a0 · Cited by 1,326
Götz, F. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02827.x · Cited by 1,178
Self-citationPeschel, A., Otto, M., Jack, R. W., Kalbacher, H., Jung, G., & Götz, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8405 · Cited by 994
Self-citationTeichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions
Weidenmaier, C., & Peschel, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1861 · Cited by 774
Self-citationHeilmann, C., Hussain, M., Peters, G., & Götz, F. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4101774.x · Cited by 700
Self-citationLysM, a widely distributed protein motif for binding to (peptido)glycans
Buist, G., Steen, A., Kok, J., & Kuipers, O. P. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06211.x · Cited by 628
Allelic replacement in Staphylococcus aureus with inducible counter-selection
Bae, T., & Schneewind, O. (2006) · Plasmid · doi:10.1016/j.plasmid.2005.05.005 · Cited by 621
Sinha, B., Francois, P. P., Nusse, O., Foti, M., Hartford, O. M., Vaudaux, P., Foster, T. J., Lew, D. P., Herrmann, M., & Krause, K.-H. (1999) · Cellular Microbiology · doi:10.1046/j.1462-5822.1999.00011.x · Cited by 563
Weidenmaier, C., Kokai-Kun, J. F., Kristian, S. A., Chanturiya, T., Kalbacher, H., Gross, M., Nicholson, G., Neumeister, B., Mond, J. J., & Peschel, A. (2004) · Nature Medicine · doi:10.1038/nm991 · Cited by 560
Self-citationBera, A., Herbert, S., Jakob, A., Vollmer, W., & Götz, F. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04446.x · Cited by 481
Self-citation
Cited by
Coagulase-Negative Staphylococci
Becker, K., Heilmann, C., & Peters, G. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-13 · Cited by 1,628
Wall Teichoic Acids of Gram-Positive Bacteria
Brown, S., Santa Maria, J. P., & Walker, S. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155620 · Cited by 966
Cell Wall Structure and Function in Lactic Acid Bacteria
Chapot-Chartier, M.-P., & Kulakauskas, S. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s9 · Cited by 410
Campbell, J., Singh, A. K., Santa Maria, J. P., Kim, Y., Brown, S., Swoboda, J. G., Mylonakis, E., Wilkinson, B. J., & Walker, S. (2011) · ACS Chemical Biology · doi:10.1021/cb100269f · Cited by 289
Bacterial Glycobiology: Rhamnose-Containing Cell Wall Polysaccharides in Gram-Positive Bacteria
Mistou, M.-Y., Sutcliffe, I. C., & van Sorge, N. M. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw006 · Cited by 215
Metadata
- Authors
- Schlag, M., Biswas, R., Krismer, B., Kohler, T., Zoll, S., Yu, W., Schwarz, H., Peschel, A., & Götz, F.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 75
- Issue
- 4
- Pages
- 864-873
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2123661253
- Cited by
- 263
- References
- 25
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Role of staphylococcal wall teichoic acid in targeting the major autolysin Atl. https://app.cochat.ai/papers/10.1111/j.1365-2958.2009.07007.x
- The paper
- Schlag, M., Biswas, R., Krismer, B., Kohler, T., Zoll, S., Yu, W., Schwarz, H., Peschel, A., & Götz, F. (2010). Role of staphylococcal wall teichoic acid in targeting the major autolysin Atl. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2009.07007.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
