The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O‐acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus
Open accessAbstract
Summary: Staphylococcus species belong to one of the few bacterial genera that are completely lysozyme resistant, which greatly contributes to their persistence and success in colonizing the skin and mucosal areas of humans and animals. In an attempt to discover the cause of lysozyme resistance, we identified a gene, oatA, in Staphylococcus aureus. The corresponding oatA deletion mutant had an increased sensitivity to lysozyme. HPLC and electrospray ionization tandem mass spectrometry analyses of the cell wall revealed that the muramic acid of peptidoglycan of the wild‐type strain was O‐acetylated at C6‐OH, whereas the muramic acid of the oatA mutant lacked this modification. The complemented oatA mutant was lysozyme resistant. We identified the first bacterial peptidoglycan‐specific O‐acetyltransferase in S. aureus and showed that OatA, an integral membrane protein, is the molecular basis for the high lysozyme resistance in staphylococci.
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Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Evavold, C. L., Ruan, J., Tan, Y., Xia, S., Wu, H., & Kagan, J. C. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.013 · Cited by 1,115
Peptidoglycan recognition by the innate immune system
Wolf, A. J., & Underhill, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.136 · Cited by 469
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Metadata
- Authors
- Bera, A., Herbert, S., Jakob, A., Vollmer, W., & Götz, F.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2004-12-09
- Volume
- 55
- Issue
- 3
- Pages
- 778-787
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2112580008
- Cited by
- 481
- References
- 35
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bera, A., Herbert, S., Jakob, A., Vollmer, W., & Götz, F. (2005). Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O‐acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2004.04446.x
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